DYSMON II. Dynamik in Sulfid- und Methanbiotopen der Ost- und Nordsee. Abschlussbericht. Bd. 1

Working from the results of DYSMON I the purpose of the DYSMON II project was to examine the emergence of sulphidic, low-oxygen environments and microorganismic and faunal responses to this. The focus was on determining the resilience of ecologically important organisms after sudden drops in sulphide concentration and tolerance of oxygen deficiency and sulphide. Whereas in DYSMON I samples had largely been taken from natural sites, DYSMON II made use of ecological manipulation experiments (tarpaulin covers) so as to simulate natural covering with algae. A real-life experiment took place at Hiddensee in May 1995 when the effects of a very thick layer of algae were examined. This natural occurrence of an anoxic, sulphidic environment permitted a comparison with the experimentally induced anoxia in the sediments. (orig.)Das Projekt DYSMON II untersuchte, aufbauend auf den Ergebnissen von DYSMON I, die Entstehung sulfidischer, sauerstoffarmer Lebensbereiche und die darauf folgende Reaktion von Mikroorganismen und Fauna. Schwerpunkte lagen dabei auf der Ermittlung der Resilienz oekologisch wichtiger Organismen nach 'Sulfideinbruechen' und auf Untersuchungen zur Toleranz gegenueber Sauerstoffmangel und Sulfid. Waren waehrend DYSMON I ueberwiegend natuerliche Standorte beprobt worden, so konnten waehrend DYSMON II oekologische Manipulationsexperimente (Planenabdeckung) vorgenommen werden, um natuerliche Algenabdeckungen zu simulieren. Als Realexperiment gelang es, im Mai 1995 am Standort Hiddensee die Auswirkung einer sehr dicken Algenschicht zu erfassen. Diese natuerliche Entstehung von anoxischen, sulfidischen Bedingungen erlaubte einen Vergleich mit der experimentell induzierten Anoxie in den Sedimenten. (orig.)Available from TIB Hannover: F97B1291 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Fever and hypothermia represent two populations of sepsis patients and are associated with outside temperature

Background!#!Fever and hypothermia have been observed in septic patients. Their influence on prognosis is subject to ongoing debates.!##!Methods!#!We did a secondary analysis of a large clinical dataset from a quality improvement trial. A binary logistic regression model was calculated to assess the association of the thermal response with outcome and a multinomial regression model to assess factors associated with fever or hypothermia.!##!Results!#!With 6542 analyzable cases we observed a bimodal temperature response characterized by fever or hypothermia, normothermia was rare. Hypothermia and high fever were both associated with higher lactate values. Hypothermia was associated with higher mortality, but this association was reduced after adjustment for other risk factors. Age, community-acquired sepsis, lower BMI and lower outside temperatures were associated with hypothermia while bacteremia and higher procalcitonin values were associated with high fever.!##!Conclusions!#!Septic patients show either a hypothermic or a fever response. Whether hypothermia is a maladaptive response, as indicated by the higher mortality in hypothermic patients, or an adaptive response in patients with limited metabolic reserves under colder environmental conditions, remains an open question. Trial registration The original trial whose dataset was analyzed was registered at ClinicalTrials.gov (NCT01187134) on August 23, 2010, the first patient was included on July 1, 2011