Experimental and Numerical Study of Blood Flow in μ-vessels: Influence of the Fahraeus–Lindqvist Effect

The study of hemodynamics is particularly important in medicine and biomedical engineering as it is crucial for the design of new implantable devices and for understanding the mechanism of various diseases related to blood flow. In this study, we experimentally identify the cell free layer (CFL) width, which is the result of the Fahraeus–Lindqvist effect, as well as the axial velocity distribution of blood flow in microvessels. The CFL extent was determined using microscopic photography, while the blood velocity was measured by micro-particle image velocimetry (μ-PIV). Based on the experimental results, we formulated a correlation for the prediction of the CFL width in small caliber (D < 300 μm) vessels as a function of a modified Reynolds number (Re∞) and the hematocrit (Hct). This correlation along with the lateral distribution of blood viscosity were used as input to a “two-regions” computational model. The reliability of the code was checked by comparing the experimentally obtained axial velocity profiles with those calculated by the computational fluid dynamics (CFD) simulations. We propose a methodology for calculating the friction loses during blood flow in μ-vessels, where the Fahraeus–Lindqvist effect plays a prominent role, and show that the pressure drop may be overestimated by 80% to 150% if the CFL is neglected

Experimental Study of Bubble Formation from a Micro-Tube in Non-Newtonian Fluid

Over the last few years, microbubbles have found application in biomedicine. In this study, the characteristics of bubbles formed when air is introduced from a micro-tube (internal diameter 110 μm) in non-Newtonian shear thinning fluids are studied. The dependence of the release time and the size of the bubbles on the gas phase rate and liquid phase properties is investigated. The geometrical characteristics of the bubbles are also compared with those formed in Newtonian fluids with similar physical properties. It was found that the final diameter of the bubbles increases by increasing the gas flow rate and the liquid phase viscosity. It was observed that the bubbles formed in a non-Newtonian fluid have practically the same characteristics as those formed in a Newtonian fluid, whose viscosity equals the asymptotic viscosity of the non-Newtonian fluid, leading to the assumption that the shear rate around an under-formation bubble is high, and the viscosity tends to its asymptotic value. To verify this notion, bubble formation was simulated using Computational Fluid Dynamics (CFD). The simulation results revealed that around an under-formation bubble, the shear rate attains a value high enough to lead the viscosity of the non-Newtonian fluid to its asymptotic value

Free-Flowing Shear-Thinning Liquid Film in Inclined μ-Channels

Among the most important variables in the design of falling film microreactors (FFMRs) is the liquid film thickness as well as the gas/liquid interfacial area, which dictate the mass and heat transfer rates. In a previous work conducted in our lab the characteristics of a free-falling Newtonian liquid film have been studied and appropriate correlations have been proposed. In this work the geometrical characteristics of a non-Newtonian shear thinning liquid, flowing in an inclined open microchannel, have been experimentally investigated and design correlations that can predict with reasonable accuracy the features of a FFMR have been proposed. The test section used was an open μ-channel with square cross section (WO = 1200 μm) made of brass which can be set to various inclination angles. The liquid film characteristics were measured by a non-intrusive technique that is based on the features of a micro Particle Image Velocimetry (μ-PIV) system. Relevant computational fluid dynamics (CFD) simulations revealed that the volume average dynamic viscosity over the flow domain is practically the same as the corresponding asymptotic viscosity value, which can thus be used in the proposed design equations. Finally, a generalized algorithm for the design of FFMRs, containing non-Newtonian shear thinning liquids, is suggested

Fluid-Structure Interaction in Abdominal Aortic Aneurysms: Effect of Haematocrit

The Abdominal Aortic Aneurysm (AAA) is a local dilation of the abdominal aorta and it is a cause for serious concern because of the high mortality associated with its rupture. Consequently, the understanding of the phenomena related to the creation and the progression of an AAA is of crucial importance. In this work, the complicated interaction between the blood flow and the AAA wall is numerically examined using a fully coupled Fluid-Structure Interaction (FSI) method. The study investigates the possible link between the dynamic behavior of an AAA and the blood viscosity variations attributed to the haematocrit value, while it also incorporates the pulsatile blood flow, the non-Newtonian behavior of blood and the hyperelasticity of the arterial wall. It was found that blood viscosity has no significant effect on von Mises stress magnitude and distribution, whereas there is a close relation between the haematocrit value and the Wall Shear Stress (WSS) magnitude in AAAs. This WSS variation can possibly alter the mechanical properties of the arterial wall and increase its growth rate or even its rupture possibility. The relationship between haematocrit and dynamic behavior of an AAA can be helpful in designing a patient specific treatment

Chemical flowers: Buoyancy-driven instabilities under modulated gravity during a parabolic flight

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Effects of gravity modulation on the dynamics of a radial A + B -> C reaction front

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