Results for selected top interactions among top marginal loci with p-value less than 5×10⁻⁵ in Phase I studies.

<p>P_het is the heterogeneity p-value.</p

Forest plot for meta-analysis results of GxG between rs1571218 and rs10879357.

<p>Box sizes are proportional to the inverse variance for each study and the lines depict the confidence intervals. The diamonds represent the fixed effects meta-analysis results, with the width of the diamond representing the confidence interval. The results of two advanced adenoma studies (HPFS Adv Adnm and NHS Adv Adnm) are shown at the bottom but not incorporated in the meta-analysis.</p

Interaction pattern between rs10795668 and rs367615.

<p>Interaction pattern between rs10795668 and rs367615.</p

An illustration of different two-SNP interaction models. SNP 1 has genotype AA, Aa and aa; SNP 2 has genotype BB, Bb, and bb. A and B are the major alleles for SNP1 and 2, respectively.

<p>Each entry in the tables represents the risk of the corresponding genotype combination relative to the baseline (AA/BB). (a) Multiplicative interaction model; (b) Unrestricted interaction model; (c) Average Risk Due to Interaction (ARDI) model.</p

Studies in Genetics and Epidemiology Colorectal Cancer Consortium (GECCO).

a<p>Sample size excludes overlap with CCFR;</p>†<p>Sample sizes given only for subjects clustering with HapMap CEU population in PCA (for data that has undergone QC);</p>¶<p>Includes participants with data downloaded from dbGaP prostate and lung studies;*for adenoma, number and % colon does not include subjects with adenomas located in both colon and rectum.</p

Regional interaction association plot for interacting region 5q21 with known CRC locus rs10795668.

<p>The left y-axis shows the -log10 of the meta-analysis interaction p value. The right y-axis shows the recombination rate. Each dot on the plot represents the result for one SNP. The diamond dot represents SNP rs367615 and the round dots represent other SNPs. Difference colors of SNPs indicate different LD strength between the corresponding SNP and rs367615, measured by r². The bottom of the figure shows the genes in the plotted region.</p

Forest plot for meta-analysis results of GxG between rs10795668 and rs367615.

<p>Box sizes are proportional to the inverse variance for each study and the lines depict the confidence intervals. The diamonds represent the fixed effects meta-analysis results, with the width of the diamond representing the confidence interval. The results of two advanced adenoma studies (HPFS Adv Adnm and NHS Adv Adnm) are shown at the bottom but not incorporated in the meta-analysis.</p

Results for selected top interactions for known CRC loci with p-value less than 10⁻⁶ in Phase I studies.

*<p>P_het is the heterogeneity p-value.</p

Top three SNPs according to lowest p-value for interactions with processed meat for risk of colorectal cancer using conventional case-control logistic regression approach.

<p>* CAF, count allele frequency. Count (or tested) allele is defined as the allele that was coded as 1 in the logistic regression (the other allele was coded as 0).</p><p>** interaction OR for each copy of the count allele and for each increasing quartile of processed meat intake.</p

Association of processed meat and risk of colorectal cancer by genotype strata for rs4143094.

<p>*Minimal adjusted models included age, sex, study site, energy and PCs.</p><p>**Multivariable adjusted models additionally included: BMI, smoking, alcohol and other dietary factors.</p><p>Multivariable-adjusted analysis is limited to samples with available data for all covariates used in the analysis.</p