WELD PROPERTIES OF SANDVIK SAF 2707 HD®

(petro-) chemical processing industry. The recently developed hyper duplex grade Sandvik SAF 2707HD® allows extension of the application range of austenitic-ferritic alloys into even more aggressive conditions. In most applications for Sandvik SAF 2707 HD the equipment needs to be welded. Hence, weldability is of utmost importance for a stainless steel grade of this kind. Weld documentation was made for a number of joints to simulate various tube- and pipe applications. The welding method used was gas tungsten arc welding. The joints were tested regarding mechanical properties, microstructure, pitting resistance and in some cases chloride stress corrosion resistance. The filler wire used, designated Sandvik 27.9.5.L, was developed specifically for Sandvik SAF 2707 HD. Overlay welds were produced using submerged-arc welding and gas tungsten arc welding. The welds were documented regarding ductility, microstructure and pitting resistance. Tube-to-tube sheet welds were also produced to document the weld behaviour and pitting resistance

Protection of the 6 T YBCO insert in the 13 T Nb3Sn Fresca II dipole

In the EuCARD project, we aim to construct a dipole magnet in YBCO producing 6 T in the background field of a 13 T Nb3Sn dipole FRESCA II. This paper reviews the quench analysis and protection of the YBCO coil. In addition, a recommendation for the protection system of the YBCO coil is presented.Comment: 6 pages, Contribution to WAMSDO 2013: Workshop on Accelerator Magnet, Superconductor, Design and Optimization; 15 - 16 Jan 2013, CERN, Geneva, Switzerlan

HTS Dipole Insert Developments

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A multidisciplinary, multifactorial intervention program reduces postoperative falls and injuries after femoral neck fracture

INTRODUCTION: This study evaluates whether a postoperative multidisciplinary, intervention program, including systematic assessment and treatment of fall risk factors, active prevention, detection, and treatment of postoperative complications, could reduce inpatient falls and fall-related injuries after a femoral neck fracture. METHODS: A randomized, controlled trial at the orthopedic and geriatric departments at Umeå University Hospital, Sweden, included 199 patients with femoral neck fracture, aged  ≥70 years. RESULTS: Twelve patients fell 18 times in the intervention group compared with 26 patients suffering 60 falls in the control group. Only one patient with dementia fell in the intervention group compared with 11 in the control group. The crude postoperative fall incidence rate was 6.29/1,000 days in the intervention group vs 16.28/1,000 days in the control group. The incidence rate ratio was 0.38 [95% confidence interval (CI): 0.20 – 0.76, p = 0.006] for the total sample and 0.07 (95% CI: 0.01–0.57, p=0.013) among patients with dementia. There were no new fractures in the intervention group but four in the control group. CONCLUSION: A team applying comprehensive geriatric assessment and rehabilitation, including prevention, detection, and treatment of fall risk factors, can successfully prevent inpatient falls and injuries, even in patients with dementia

Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon

Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in intestinal epithelial cells (floxed K8 and Villin-Cre1000 and Villin-CreERt2) to investigate the cell-specific roles of intestinal epithelial K8 for colonocyte function and pathologies. Intestinal epithelial K8 deletion decreased K8 partner proteins, K18-K20, 75-95%, and the remaining keratin filaments were located at the colonocyte apical regions with type II K7, which decreased 30%. 2-Deoxy-2-[18F]-fluoroglucose positron emission tomography in vivo imaging identified a metabolic phenotype in the lower gut of the conditional K8 knockouts. These mice developed intestinal barrier leakiness, mild diarrhea, and epithelial damage, especially in the proximal colon. Mice exhibited shifted differentiation from enterocytes to goblet cells, displayed longer crypts and an increased number of Ki67 + transit-amplifying cells in the colon. Significant proproliferative and regenerative signaling occurred in the IL-22, STAT3, and pRb pathways, with minor effects on inflammatory parameters, which, however, increased in aging mice. Importantly, colonocyte K8 deletion induced a dramatically increased sensitivity to azoxymethane-induced tumorigenesis. In conclusion, intestinal epithelial K8 plays a significant role in colonocyte epithelial integrity maintenance, proliferation regulation and tumor suppression.</p