103 research outputs found
Systemic multipotent adult progenitor cells improve long-term neurodevelopmental outcomes after preterm hypoxic-ischemic encephalopathy
There is an urgent need for therapies that could reduce the disease burden of preterm hypoxic-ischemic encephalopathy. Here, we evaluate the long-term effects of multipotent adult progenitor cells (MAPC) on long-term behavioral outcomes in a preterm rat model of perinatal asphyxia. Rats of both sexes were treated with two doses of MAPCs within 24 h after the insult. Locomotor, cognitive and psychiatric impairments were evaluated starting at 1.5 (juvenile) and 6 months (adult). Hypoxia-ischemia affected locomotion, cognition, and anxiety in a sex-dependent manner, with higher vulnerability observed in males. The MAPC therapy partially attenuated deficits in object recognition memory in females of all tested ages, and in the adult males. The hypoxic insult caused delayed hyperactivity in adult males, which was corrected by MAPC therapy. These results suggest that MAPCs may have long-term benefits for neurodevelopmental outcome after preterm birth and global hypoxia-ischemia, which warrants further preclinical exploration
Electro-oscillographic correlation between dorsal raphe nucleus, neocortex and hippocampus during wakefulness before and after serotoninergic inactivation
Serotonergic neurons in the caudal raphe nuclei discharge in association with activity of masticatory muscles
Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains
Assessing segmental versus non-segmental features in the ventral nervous system of onychophorans (velvet worms)
Behavioral correlates of the activity of serotonergic and non-serotonergic neurons in caudal raphe nuclei
Functional anatomy of 5-HT2A receptors in the amygdala and hippocampal complex: relevance to memory functions
THE CONNECTIONS BETWEEN THE SEPTUM DIAGONAL BAND COMPLEX AND HISTAMINERGIC NEURONS IN THE POSTERIOR HYPOTHALAMUS OF THE RAT - ANTEROGRADE TRACING WITH PHASEOLUS-VULGARIS-LEUCOAGGLUTININ COMBINED WITH IMMUNOCYTOCHEMISTRY OF HISTIDINE-DECARBOXYLASE
THE CONNECTIONS BETWEEN THE SEPTUM DIAGONAL BAND COMPLEX AND HISTAMINERGIC NEURONS IN THE POSTERIOR HYPOTHALAMUS OF THE RAT - ANTEROGRADE TRACING WITH PHASEOLUS-VULGARIS-LEUCOAGGLUTININ COMBINED WITH IMMUNOCYTOCHEMISTRY OF HISTIDINE-DECARBOXYLASE
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