Magnetohydrodynamic turbulence in warped accretion discs

Warped, precessing accretion discs appear in a range of astrophysical systems, for instance the X-ray binary Her X-1 and in the active nucleus of NGC4258. In a warped accretion disc there are horizontal pressure gradients that drive an epicyclic motion. We have studied the interaction of this epicyclic motion with the magnetohydrodynamic turbulence in numerical simulations. We find that the turbulent stress acting on the epicyclic motion is comparable in size to the stress that drives the accretion, however an important ingredient in the damping of the epicyclic motion is its parametric decay into inertial waves.Comment: to appear in the proceedings of the 20th Texas Symposium on Relativistic Astrophysics, J. C. Wheeler & H. Martel (eds.

Fluorescence kinetics of chloroplasts as indicators of disorders in the photosynthetic system I. Comparative studies with greening leaves of Vitis and Hordeum

Kinetics of both delayed fluorescence (luminescence) and prompt fluorescence of chlorophyll are used to characterize photosynthetic activity in leaf tissues. In a first attempt the greening process in etiolated Vitis cuttings and Hordeum seedlings was studied. Data sampling and processing, including averaging of the kinetics, was carried out by means of a microcomputer. Parallel to the light-induced development of photosynthetic activity the kinetic changes (i. e. luminescence decrease, fluorescence rise and decrease) became more prominent and transitory secondary peaks appeared. For both plants the succession of the kinetic characteristics was the same; it only differed in the time of appearance. The kinetics are discussed according to interpretations given in literature. The method is proposed as a tool to quickly characterize certain damages of the photosynthetic system in different plants

The response of a turbulent accretion disc to an imposed epicyclic shearing motion

We excite an epicyclic motion, whose amplitude depends on the vertical position, $z$, in a simulation of a turbulent accretion disc. An epicyclic motion of this kind may be caused by a warping of the disc. By studying how the epicyclic motion decays we can obtain information about the interaction between the warp and the disc turbulence. A high amplitude epicyclic motion decays first by exciting inertial waves through a parametric instability, but its subsequent exponential damping may be reproduced by a turbulent viscosity. We estimate the effective viscosity parameter, $\alpha_{\rm v}$, pertaining to such a vertical shear. We also gain new information on the properties of the disc turbulence in general, and measure the usual viscosity parameter, $\alpha_{\rm h}$, pertaining to a horizontal (Keplerian) shear. We find that, as is often assumed in theoretical studies, $\alpha_{\rm v}$ is approximately equal to $\alpha_{\rm h}$ and both are much less than unity, for the field strengths achieved in our local box calculations of turbulence. In view of the smallness ($\sim 0.01$) of $\alpha_{\rm v}$ and $\alpha_{\rm h}$ we conclude that for $\beta = p_{\rm gas}/p_{\rm mag} \sim 10$ the timescale for diffusion or damping of a warp is much shorter than the usual viscous timescale. Finally, we review the astrophysical implications.Comment: 12 pages, 18 figures, MNRAS accepte

Epigenetic silencing of miR-520c leads to induced S100A4 expression and its mediated colorectal cancer progression

The S100 calcium-binding protein A4 (S100A4) induces epithelial mesenchymal transition, migration, invasion, angiogenesis and metastasis. Its induced expression in several cancer types correlates with poor prognosis. Apart from the functional and transcriptional regulatory aspects of S100A4, its post-transcriptional regulation is not yet clearly elucidated. In this study, we show that microRNAs (miR) miR-505-5p and miR-520c-3p target the 3'-UTR of S100A4 and inhibits its expression and its mediated migration and invasion. 5-Aza treatment significantly increased miR-520c-3p expression and reduced the S100A4 protein amounts. The upstream promoter region of miR-520c is hypermethylated irrespective of the metastasis status of colorectal cancer (CRC) patient tissues and in all analyzed CRC cell lines. Moreover, in a cohort of CRC patient specimen (n = 59), miR-520c-3p was significantly downregulated. miR-520c-3p stably expressing HCT116 cells showed a reduced metastasis formation in livers after implanting in mice spleen. Taken together, our findings demonstrate that S100A4 is post-transcriptionally regulated by tumor suppressor miRs, miR-505c-5p and miR-520c-3p, and particularly miR-520c-3p expression is epigenetically silenced in CRC

MACC1 is post-transcriptionally regulated by miR-218 in colorectal cancer

Metastasis is a multistep molecular network process, which is lethal for more than 90% of the cancer patients. Understanding the regulatory functions of metastasis-inducing molecules is in high demand for improved therapeutic cancer approaches. Thus, we studied the post-transcriptional regulation of the crucial carcinogenic and metastasis-mediating molecule metastasis associated in colon cancer 1 (MACC1). In silico analysis revealed MACC1 as a potential target of miR-218, a tumor suppressor miRNA. Expression of these two molecules inversely correlated in colorectal cancer (CRC) cell lines. In a cohort of CRC patient tissues (n = 59), miR-218 is significantly downregulated and MACC1 is upregulated compared with normal mucosa. Luciferase reporter assays with a construct of the MACC1-3'-UTR harboring either the wild type or the mutated miR-218 seed sequence confirmed the specificity of the targeting. miR-218 inhibited significantly MACC1 protein expression, and consistently, MACC1-mediated migration, invasion and colony formation in CRC cells. Anti-miR-218 enhanced the MACC1-mediated migration, invasion and colony formation. Similar findings were observed in the gastric cancer cell line MKN-45. Further, we performed methylation-specific PCR of the SLIT2 and SLIT3 promoter, where miR-218 is encoded in intronic regions. The SLIT2 and SLIT3 promoters are hypermethylated in CRC cell lines. miR-218 and SLIT2 expressions correlated positively. Methyltransferase inhibitor 5-Azacytidine induced miR-218 expression and inhibited the expression of its target MACC1. We also determined that MACC1 has alternative polyadenylation (APA) sites, which results in different lengths of 3'-UTR variants in a CRC cell line. Taken together, miR-218 is post-transcriptionally inhibiting the MACC1 expression and its metastasis-inducing abilities

U.S. Supreme Court takes accessibility to a new level: Renewed Hope for the Americans with Disabilities Act

Gives an account of the U.S. Supreme Court case Tennessee vs. Lane, in which a paraplegic sued the State of Tennessee alleging that the lack of disabled access to the Polk County Courthouse violated the Americans with Disabilities Act (ADA)

A Sobolev Poincar\'e type inequality for integral varifolds

In this work a local inequality is provided which bounds the distance of an integral varifold from a multivalued plane (height) by its tilt and mean curvature. The bounds obtained for the exponents of the Lebesgue spaces involved are shown to be sharp.Comment: v1: 27 pages, no figures; v2: replaced citations of the author's dissertation by proofs, material of sections 1 and 3 reorganised, slightly more general results in section 2, some remarks, some discussion and some references added, 40 pages, no figure