Fracture behaviour and damage characterisation in composite impact panels by laboratory X-ray computed tomography

<p>Presentation from Thermosets 2013, From Monomers to Components Conference in Berlin, Germany 16-18 September 2013.</p

Ultrastrukturelle Analyse der Aufnahme von Nanopartikeln in Trypanosoma brucei brucei

Bis zum heutigen Zeitpunkt sind nur 5 Medikamente zur Behandlung der afrikanischen Schlafkrankheit (HAT) auf dem Markt, die aber alle aufgrund von starken Nebenwirkungen und Schwierigkeiten bei der Verabreichung nicht zufriedenstellend sind [51]. Nanopartikel könnten hierbei als Medikamenten-Carrier eingesetzt werden und einen neuen Therapieansatz bieten. Im ersten Teil dieser Arbeit sollte deshalb zunächst die Toxizität der Silizium- und Eisenoxidnanopartikel auf Trypanosoma brucei brucei und Erythrozyten untersucht werden, um eruieren zu können welcher der Nanopartikel als möglicher Medikamenten-Carrier eingesetzt werden könnte. Die Siliziumpartikel waren ab einer Konzentration von ≥ 50µg/ml trypanozid und die TC50 gegenüber Erythrozyten lag bei 15,6µg/ml. Mittels Fluoreszenzmikrospie konnte gezeigt werden, dass die Siliziumpartikel in die Membran der Erythrozyten inserierten und somit zu deren Lyse führten. Die nackten Fe2O3 Partikel zeigten hingegen im getesteten Konzentrationsbereich von 0,1µg/ml - 1000µg/ml keinen Einfluss in der exponentiellen Wachstumsphase der Trypanosomen. Es kam jedoch ab einer Konzentration von 100µg/ml zu einer verkürzten stationären Phase, die mit steigender Konzentration deutlich zunahm. Aufgrund dieser Ergebnisse wurden die Siliziumpartikel in Bezug auf die Medikamentenentwicklung zur Bekämpfung der HAT als ungeeignet eingestuft. Im weiteren Verlauf der Arbeit wurde daher ausschließlich mit den Eisenoxidnanopartikeln weiter gearbeitet. Im zweiten Teil der Arbeit sollte nun die Oberfläche der Eisenoxidnanopartikel hinsichtlich der Medikamentenentwicklung verbessert und die Toxizität der modifizierten Eisenoxidnanopartikel an Trypanosomen getestet werden. Um die nackten Fe2O3-Partikel während der Anwendung in Medium zu stabilisieren und ihre geringe Toxizität auf Trypanosomen noch weiter zu verringern, wurden sie zunächst mit unterschiedlichen Sialinsäurederivaten (AllylthioNeu5AC, APS, NANA) oder mit dem synthetischen Polymer Polyvinylalkohol (PVA) ummantelt. Bei der Negativkontrastierung der nackten Fe2O3 und der Fe2O3-PVA Partikel zeigte sich, dass die Agglomeration der Partikel durch den PVA-Mantel deutlich reduziert werden konnte. Deshalb wurde im weiteren Verlauf ausschließlich mit den Fe2O3-PVA Partikeln weiter gearbeitet. Darüber hinaus wurde die Oberfläche der Nanopartikel noch zusätzlich mit den Proteinen bovine serum albumin (BSA) oder mit humanem Transferrin (Tf) modifiziert, um eine Aufnahme in die Parasiten durch Pinozytose oder Rezeptor-vermittelte Endozytose zu sichern [129]. Alle drei Nanopartikel-Chargen (Fe2O3-PVA, Fe2O3- PVA- BSA, Fe2O3-PVA-Tf) wurden noch zusätzlich mit dem Fluorophor Fluoresceinisothiocyanat (FITC) modifiziert, damit die Aufnahmekinetik mittels Durchflusszytometrie untersucht und verglichen werden konnte. Keiner der genannten modifizierten Partikel zeigte im Bereich von 0,1µg/ml - 1000µg/ml einen inhibitorischen Effekt auf die Trypanosomen. Die hämolytische Wirkung der Fe2O3-PVA, Fe2O3-PVA-BSA und Fe2O3-PVA-Tf Partikel war ≤ 3%, weshalb diese Partikel als geeignete Kandidaten für den Medikamententransport eingestuft wurden. Im dritten Teil dieser Arbeit sollte untersucht werden, inwiefern ein Proteinmantel für die Aufnahme der Eisenoxidnanopartikel nötig ist und ob Serumproteine einen Einfluss auf die Aufnahme der Partikel haben. Deshalb wurde die Aufnahmekinetik aller drei Eisenoxidnanopartikel (Fe2O3-PVA-DTAF, Fe2O3-PVA-BSA-FITC und Fe2O3-PVA-Tf-FITC) unter serumfreien und serumhaltigen Bedingungen mittels Durchflusszytometrie analysiert. Es konnte gezeigt werden, dass es bei allen drei Partikeln in serumhaltigem Medium zu einem zeit- und konzentrationsabhängigen Anstieg im prozentualen Anteil der FITC-A positiven Zellen kam. Jedoch zeigte sich, dass bei allen drei Partikeltypen, unabhängig vom Proteinmantel, Konzentrationen bis zu 1000µg/ml nötig waren, um eine Aufnahme in ca. 80-95% der Zellen zu erreichen. Es zeigte sich ebenfalls, dass Inkubationszeiten von bis zu 12h bei den beiden proteinbeschichteten Partikeltypen und Inkubationszeiten bis zu 24h bei den unbeschichteten Fe2O3-PVA Partikeln für eine effiziente Aufnahme nötig waren. Diese langen Inkubationszeiten waren aufgrund der hohen Endozytoserate von Trypanosomen nicht zu erwarten gewesen [129]. Wurden die Versuche hingegen unter serumfreien Bedingungen durchgeführt, kam es bei den beiden proteinbeschichteten Partikeln während der 1-stündigen Inkubation ab einer Konzentration von ≥ 10µg/ml zu einem rasanten konzentrationsabhängigen Anstieg im prozentualen Anteil der fluoreszierenden Zellen. Die Aufnahme der unbeschichteten Fe2O3-PVA Partikel war hingegen selbst unter serumfreien Bedingungen kaum möglich. Bei einer Konzentration von 1mg/ml war nur bei ca. 20% der Zellen ein Fluoreszenzsignal messbar. So konnte gezeigt werden, dass bei der Entwicklung von Nanopartikeln als Medikamenten-Carrier sowohl die Wirkung von Serumproteinen als auch die Notwendigkeit eines Proteinmantels berücksichtigt werden sollte. Im letzten Teil der Arbeit sollte die Aufnahme der Partikel bestätigt und ihre Lokalisation innerhalb der Zelle mittels der Transmissionselektronenmikroskopie (TEM) analysiert werden. Es konnte sowohl die Aufnahme der Siliziumpartikel als auch die der Eisenoxidnanopartikel (Fe2O3-AllylthioNeu5Ac, Fe2O3-APS, Fe2O3-NANA, Fe2O3-PVA, Fe2O3-PVA-BSA-FITC, Fe2O3-PVA-Tf-FITC) unter serumhaltigen Bedingungen bestätigt werden. Alle Partikel befanden sich größtenteils in den Lysosomen oder in den Endosomen. Unter serumfreien Bedingungen konnte nur die Aufnahme der beiden proteinbeschichteten Partikel nachgewiesen werden. Die Nanopartikel konnten in der Flagellumtasche, in endozytotischen Vesikeln, Lysosomen und Autolysosomen gefunden werden. Es konnten ebenfalls zahlreiche multivesikuläre Strukturen in den Mitochondrien detektiert werden, was für eine autophagische Antwort der Zellen auf einen durch Nanopartikel induzierten Stress hindeutet. Dass es sich bei der Aufnahme der Fe2O3-PVA-BSA-FITC und Fe2O3-PVA-Tf-FITC Partikel um einen aktiven Prozess handelte, konnte ebenfalls mittels TEM bestätigt werden. Aufgrund dieser Ergebnisse wurden die Siliziumpartikel als ungeeignet und die Eisenoxidnanopartikel als ein möglicher geeigneter Medikamenten-Carrier zur Bekämpfung der HAT eingestuft. Da die Eisenoxidnanopartikel keine Toxizität auf die Trypanosomen bis zu einer Konzentration von 1mg/ml zeigten und in den Lysosomen akkumulierten, könnte in Zukunft eine selektive Abtötung der Parasiten durch die Kopplung eines Nanobodies gegen ein konserviertes Epitop im GPI-Anker von VSG [187, 204] und die zusätzliche Kopplung eines spezifischen Inhibitors lysosomaler Cysteinproteasen einen neuen Therapieansatz bieten

ECPGR recommended simple sequence repeat loci for analyses of European plum (Prunus domestica) collections

A set of nine Simple Sequence Repeat (SSR) loci, approved by the ECPGR Prunus working group, are proposed as a standard set for genotyping European plum accessions. These loci show sufficient reliability in spite of problems caused by hexaploidy. Polymorphism in the loci is high and enables differentiation between unique plum accessions as well as analyses of genetic grouping and overall genetic structure. A set of seven reference accessions are described. A compiled dataset with allelic information for 165 accessions is presented. Genetic structure reveals three different K-values (2, 4 and 9) demonstrating a major dichotomy between Prunus insititia-related accessions and cultivars belonging to Prunus domestica sensu stricto, as well as differentiation among minor subgroups defined by pomological traits and geographical origin

Tailored e-Health services for the dementia care setting: a pilot study of ‘eHealthMonitor’

Background The European eHealthMonitor project (eHM) developed a user-sensitive and interactive web portal for dementia care: the eHM Dementia Portal (eHM-DP). It aims to provide targeted and personalized support for informal caregivers of people with dementia in a home-based care setting. The objective of the pilot study was to obtain feedback on the eHM-DP from two user perspectives (caregivers and medical professionals), focusing on caregiver empowerment, decision aid, and the perceived benefits of the eHM-DP. Methods The study on the eHM-DP was conducted from March 2014 to June 2014. The methodological approach followed a user-participatory design with a total number of 42 participants. The study included caregivers of people with dementia and medical professionals (MPs) from the metropolitan region of Erlangen-Nürnberg (Bavaria, Germany). Study participants were interviewed face-to-face with semi-structured, written interviews. Results Caregivers indicated a high degree of perceived support by the eHM-DP and of provided decision aid. In total, 89 % of caregivers and 54 % of MPs would use the eHM-DP if access were provided. The primary benefits participants perceived were the acquisition of individualized information, computerized interaction between caregivers and MPs, empowerment in health-related decisions and comprehensive insights into the progress of the disease. Major recommendations for improving the eHM-DP encompassed: an active search functionality based on predefined terms, the implementation of a chatroom for caregivers, an upload function and alerts for MPs, as well as the overall design. Conclusions Our study is the first to have provided new insights and results on an interactive and needs-oriented web portal, endeavouring towards empowerment and assistance in decision making for caregivers as well as MPs within the realm of caring for patients with dementia. The acceptance and willingness to use the eHM-DP emphasizes the potential of eHealth services for community-based dementia care settings

Modelling and empirical development of an anti/de-icing approach for wind turbine blades through superposition of different types of vibration

The generation of green, safe and inexpensive energy by wind turbines is often decreased or interrupted in severe climate areas during cold weather. When the blades are even partially covered by different types of ice, their efficiency drops suddenly due to degradation of the blade profile from the ideal. The present study presents a new approach using ultrasonic guided waves as an anti/de-icing technique supplemented by low-frequency vibrations to effect shedding of the ice from the turbine blades. The study consists of a series of steps including initial theoretical studies and finite element simulation of representative plates and turbine blades, followed by a number of experimental validations concluded by tests of the complete approach in an icing wind tunnel. The results show the efficacy of the developed approach in tackling the different types of ice which can form on the blades, using very low power compared to available thermal techniques

Interoception in anxiety and depression

We review the literature on interoception as it relates to depression and anxiety, with a focus on belief, and alliesthesia. The connection between increased but noisy afferent interoceptive input, self-referential and belief-based states, and top-down modulation of poorly predictive signals is integrated into a neuroanatomical and processing model for depression and anxiety. The advantage of this conceptualization is the ability to specifically examine the interface between basic interoception, self-referential belief-based states, and enhanced top-down modulation to attenuate poor predictability. We conclude that depression and anxiety are not simply interoceptive disorders but are altered interoceptive states as a consequence of noisily amplified self-referential interoceptive predictive belief states

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational, and transcriptional changes, which contribute to MYC oncogene dysregulation together with the pathognomonic IG-MYC translocation. Moreover, by mapping IGH translocation breakpoints, we provide evidence that the precursor of at least a subset of BL is a B-cell poised to express IGHA. We describe the landscape of mutations, structural variants, and mutational processes, and identified a series of driver genes in the pathogenesis of BL, which can be targeted by various mechanisms, including IG-non MYC translocations, germline and somatic mutations, fusion transcripts, and alternative splicing

Human Practice. Digital Ecologies. Our Future. : 14. Internationale Tagung Wirtschaftsinformatik (WI 2019) : Tagungsband

Erschienen bei: universi - Universitätsverlag Siegen. - ISBN: 978-3-96182-063-4Aus dem Inhalt: Track 1: Produktion & Cyber-Physische Systeme Requirements and a Meta Model for Exchanging Additive Manufacturing Capacities Service Systems, Smart Service Systems and Cyber- Physical Systems—What’s the difference? Towards a Unified Terminology Developing an Industrial IoT Platform – Trade-off between Horizontal and Vertical Approaches Machine Learning und Complex Event Processing: Effiziente Echtzeitauswertung am Beispiel Smart Factory Sensor retrofit for a coffee machine as condition monitoring and predictive maintenance use case Stakeholder-Analyse zum Einsatz IIoT-basierter Frischeinformationen in der Lebensmittelindustrie Towards a Framework for Predictive Maintenance Strategies in Mechanical Engineering - A Method-Oriented Literature Analysis Development of a matching platform for the requirement-oriented selection of cyber physical systems for SMEs Track 2: Logistic Analytics An Empirical Study of Customers’ Behavioral Intention to Use Ridepooling Services – An Extension of the Technology Acceptance Model Modeling Delay Propagation and Transmission in Railway Networks What is the impact of company specific adjustments on the acceptance and diffusion of logistic standards? Robust Route Planning in Intermodal Urban Traffic Track 3: Unternehmensmodellierung & Informationssystemgestaltung (Enterprise Modelling & Information Systems Design) Work System Modeling Method with Different Levels of Specificity and Rigor for Different Stakeholder Purposes Resolving Inconsistencies in Declarative Process Models based on Culpability Measurement Strategic Analysis in the Realm of Enterprise Modeling – On the Example of Blockchain-Based Initiatives for the Electricity Sector Zwischenbetriebliche Integration in der Möbelbranche: Konfigurationen und Einflussfaktoren Novices’ Quality Perceptions and the Acceptance of Process Modeling Grammars Entwicklung einer Definition für Social Business Objects (SBO) zur Modellierung von Unternehmensinformationen Designing a Reference Model for Digital Product Configurators Terminology for Evolving Design Artifacts Business Role-Object Specification: A Language for Behavior-aware Structural Modeling of Business Objects Generating Smart Glasses-based Information Systems with BPMN4SGA: A BPMN Extension for Smart Glasses Applications Using Blockchain in Peer-to-Peer Carsharing to Build Trust in the Sharing Economy Testing in Big Data: An Architecture Pattern for a Development Environment for Innovative, Integrated and Robust Applications Track 4: Lern- und Wissensmanagement (e-Learning and Knowledge Management) eGovernment Competences revisited – A Literature Review on necessary Competences in a Digitalized Public Sector Say Hello to Your New Automated Tutor – A Structured Literature Review on Pedagogical Conversational Agents Teaching the Digital Transformation of Business Processes: Design of a Simulation Game for Information Systems Education Conceptualizing Immersion for Individual Learning in Virtual Reality Designing a Flipped Classroom Course – a Process Model The Influence of Risk-Taking on Knowledge Exchange and Combination Gamified Feedback durch Avatare im Mobile Learning Alexa, Can You Help Me Solve That Problem? - Understanding the Value of Smart Personal Assistants as Tutors for Complex Problem Tasks Track 5: Data Science & Business Analytics Matching with Bundle Preferences: Tradeoff between Fairness and Truthfulness Applied image recognition: guidelines for using deep learning models in practice Yield Prognosis for the Agrarian Management of Vineyards using Deep Learning for Object Counting Reading Between the Lines of Qualitative Data – How to Detect Hidden Structure Based on Codes Online Auctions with Dual-Threshold Algorithms: An Experimental Study and Practical Evaluation Design Features of Non-Financial Reward Programs for Online Reviews: Evaluation based on Google Maps Data Topic Embeddings – A New Approach to Classify Very Short Documents Based on Predefined Topics Leveraging Unstructured Image Data for Product Quality Improvement Decision Support for Real Estate Investors: Improving Real Estate Valuation with 3D City Models and Points of Interest Knowledge Discovery from CVs: A Topic Modeling Procedure Online Product Descriptions – Boost for your Sales? Entscheidungsunterstützung durch historienbasierte Dienstreihenfolgeplanung mit Pattern A Semi-Automated Approach for Generating Online Review Templates Machine Learning goes Measure Management: Leveraging Anomaly Detection and Parts Search to Improve Product-Cost Optimization Bedeutung von Predictive Analytics für den theoretischen Erkenntnisgewinn in der IS-Forschung Track 6: Digitale Transformation und Dienstleistungen Heuristic Theorizing in Software Development: Deriving Design Principles for Smart Glasses-based Systems Mirroring E-service for Brick and Mortar Retail: An Assessment and Survey Taxonomy of Digital Platforms: A Platform Architecture Perspective Value of Star Players in the Digital Age Local Shopping Platforms – Harnessing Locational Advantages for the Digital Transformation of Local Retail Outlets: A Content Analysis A Socio-Technical Approach to Manage Analytics-as-a-Service – Results of an Action Design Research Project Characterizing Approaches to Digital Transformation: Development of a Taxonomy of Digital Units Expectations vs. Reality – Benefits of Smart Services in the Field of Tension between Industry and Science Innovation Networks and Digital Innovation: How Organizations Use Innovation Networks in a Digitized Environment Characterising Social Reading Platforms— A Taxonomy-Based Approach to Structure the Field Less Complex than Expected – What Really Drives IT Consulting Value Modularity Canvas – A Framework for Visualizing Potentials of Service Modularity Towards a Conceptualization of Capabilities for Innovating Business Models in the Industrial Internet of Things A Taxonomy of Barriers to Digital Transformation Ambidexterity in Service Innovation Research: A Systematic Literature Review Design and success factors of an online solution for cross-pillar pension information Track 7: IT-Management und -Strategie A Frugal Support Structure for New Software Implementations in SMEs How to Structure a Company-wide Adoption of Big Data Analytics The Changing Roles of Innovation Actors and Organizational Antecedents in the Digital Age Bewertung des Kundennutzens von Chatbots für den Einsatz im Servicedesk Understanding the Benefits of Agile Software Development in Regulated Environments Are Employees Following the Rules? On the Effectiveness of IT Consumerization Policies Agile and Attached: The Impact of Agile Practices on Agile Team Members’ Affective Organisational Commitment The Complexity Trap – Limits of IT Flexibility for Supporting Organizational Agility in Decentralized Organizations Platform Openness: A Systematic Literature Review and Avenues for Future Research Competence, Fashion and the Case of Blockchain The Digital Platform Otto.de: A Case Study of Growth, Complexity, and Generativity Track 8: eHealth & alternde Gesellschaft Security and Privacy of Personal Health Records in Cloud Computing Environments – An Experimental Exploration of the Impact of Storage Solutions and Data Breaches Patientenintegration durch Pfadsysteme Digitalisierung in der Stressprävention – eine qualitative Interviewstudie zu Nutzenpotenzialen User Dynamics in Mental Health Forums – A Sentiment Analysis Perspective Intent and the Use of Wearables in the Workplace – A Model Development Understanding Patient Pathways in the Context of Integrated Health Care Services - Implications from a Scoping Review Understanding the Habitual Use of Wearable Activity Trackers On the Fit in Fitness Apps: Studying the Interaction of Motivational Affordances and Users’ Goal Orientations in Affecting the Benefits Gained Gamification in Health Behavior Change Support Systems - A Synthesis of Unintended Side Effects Investigating the Influence of Information Incongruity on Trust-Relations within Trilateral Healthcare Settings Track 9: Krisen- und Kontinuitätsmanagement Potentiale von IKT beim Ausfall kritischer Infrastrukturen: Erwartungen, Informationsgewinnung und Mediennutzung der Zivilbevölkerung in Deutschland Fake News Perception in Germany: A Representative Study of People’s Attitudes and Approaches to Counteract Disinformation Analyzing the Potential of Graphical Building Information for Fire Emergency Responses: Findings from a Controlled Experiment Track 10: Human-Computer Interaction Towards a Taxonomy of Platforms for Conversational Agent Design Measuring Service Encounter Satisfaction with Customer Service Chatbots using Sentiment Analysis Self-Tracking and Gamification: Analyzing the Interplay of Motivations, Usage and Motivation Fulfillment Erfolgsfaktoren von Augmented-Reality-Applikationen: Analyse von Nutzerrezensionen mit dem Review-Mining-Verfahren Designing Dynamic Decision Support for Electronic Requirements Negotiations Who is Stressed by Using ICTs? A Qualitative Comparison Analysis with the Big Five Personality Traits to Understand Technostress Walking the Middle Path: How Medium Trade-Off Exposure Leads to Higher Consumer Satisfaction in Recommender Agents Theory-Based Affordances of Utilitarian, Hedonic and Dual-Purposed Technologies: A Literature Review Eliciting Customer Preferences for Shopping Companion Apps: A Service Quality Approach The Role of Early User Participation in Discovering Software – A Case Study from the Context of Smart Glasses The Fluidity of the Self-Concept as a Framework to Explain the Motivation to Play Video Games Heart over Heels? An Empirical Analysis of the Relationship between Emotions and Review Helpfulness for Experience and Credence Goods Track 11: Information Security and Information Privacy Unfolding Concerns about Augmented Reality Technologies: A Qualitative Analysis of User Perceptions To (Psychologically) Own Data is to Protect Data: How Psychological Ownership Determines Protective Behavior in a Work and Private Context Understanding Data Protection Regulations from a Data Management Perspective: A Capability-Based Approach to EU-GDPR On the Difficulties of Incentivizing Online Privacy through Transparency: A Qualitative Survey of the German Health Insurance Market What is Your Selfie Worth? A Field Study on Individuals’ Valuation of Personal Data Justification of Mass Surveillance: A Quantitative Study An Exploratory Study of Risk Perception for Data Disclosure to a Network of Firms Track 12: Umweltinformatik und nachhaltiges Wirtschaften Kommunikationsfäden im Nadelöhr – Fachliche Prozessmodellierung der Nachhaltigkeitskommunikation am Kapitalmarkt Potentiale und Herausforderungen der Materialflusskostenrechnung Computing Incentives for User-Based Relocation in Carsharing Sustainability’s Coming Home: Preliminary Design Principles for the Sustainable Smart District Substitution of hazardous chemical substances using Deep Learning and t-SNE A Hierarchy of DSMLs in Support of Product Life-Cycle Assessment A Survey of Smart Energy Services for Private Households Door-to-Door Mobility Integrators as Keystone Organizations of Smart Ecosystems: Resources and Value Co-Creation – A Literature Review Ein Entscheidungsunterstützungssystem zur ökonomischen Bewertung von Mieterstrom auf Basis der Clusteranalyse Discovering Blockchain for Sustainable Product-Service Systems to enhance the Circular Economy Digitale Rückverfolgbarkeit von Lebensmitteln: Eine verbraucherinformatische Studie Umweltbewusstsein durch audiovisuelles Content Marketing? Eine experimentelle Untersuchung zur Konsumentenbewertung nachhaltiger Smartphones Towards Predictive Energy Management in Information Systems: A Research Proposal A Web Browser-Based Application for Processing and Analyzing Material Flow Models using the MFCA Methodology Track 13: Digital Work - Social, mobile, smart On Conversational Agents in Information Systems Research: Analyzing the Past to Guide Future Work The Potential of Augmented Reality for Improving Occupational First Aid Prevent a Vicious Circle! The Role of Organizational IT-Capability in Attracting IT-affine Applicants Good, Bad, or Both? Conceptualization and Measurement of Ambivalent User Attitudes Towards AI A Case Study on Cross-Hierarchical Communication in Digital Work Environments ‘Show Me Your People Skills’ - Employing CEO Branding for Corporate Reputation Management in Social Media A Multiorganisational Study of the Drivers and Barriers of Enterprise Collaboration Systems-Enabled Change The More the Merrier? The Effect of Size of Core Team Subgroups on Success of Open Source Projects The Impact of Anthropomorphic and Functional Chatbot Design Features in Enterprise Collaboration Systems on User Acceptance Digital Feedback for Digital Work? Affordances and Constraints of a Feedback App at InsurCorp The Effect of Marker-less Augmented Reality on Task and Learning Performance Antecedents for Cyberloafing – A Literature Review Internal Crowd Work as a Source of Empowerment - An Empirical Analysis of the Perception of Employees in a Crowdtesting Project Track 14: Geschäftsmodelle und digitales Unternehmertum Dividing the ICO Jungle: Extracting and Evaluating Design Archetypes Capturing Value from Data: Exploring Factors Influencing Revenue Model Design for Data-Driven Services Understanding the Role of Data for Innovating Business Models: A System Dynamics Perspective Business Model Innovation and Stakeholder: Exploring Mechanisms and Outcomes of Value Creation and Destruction Business Models for Internet of Things Platforms: Empirical Development of a Taxonomy and Archetypes Revitalizing established Industrial Companies: State of the Art and Success Principles of Digital Corporate Incubators When 1+1 is Greater than 2: Concurrence of Additional Digital and Established Business Models within Companies Special Track 1: Student Track Investigating Personalized Price Discrimination of Textile-, Electronics- and General Stores in German Online Retail From Facets to a Universal Definition – An Analysis of IoT Usage in Retail Is the Technostress Creators Inventory Still an Up-To-Date Measurement Instrument? Results of a Large-Scale Interview Study Application of Media Synchronicity Theory to Creative Tasks in Virtual Teams Using the Example of Design Thinking TrustyTweet: An Indicator-based Browser-Plugin to Assist Users in Dealing with Fake News on Twitter Application of Process Mining Techniques to Support Maintenance-Related Objectives How Voice Can Change Customer Satisfaction: A Comparative Analysis between E-Commerce and Voice Commerce Business Process Compliance and Blockchain: How Does the Ethereum Blockchain Address Challenges of Business Process Compliance? Improving Business Model Configuration through a Question-based Approach The Influence of Situational Factors and Gamification on Intrinsic Motivation and Learning Evaluation von ITSM-Tools für Integration und Management von Cloud-Diensten am Beispiel von ServiceNow How Software Promotes the Integration of Sustainability in Business Process Management Criteria Catalog for Industrial IoT Platforms from the Perspective of the Machine Tool Industry Special Track 3: Demos & Prototyping Privacy-friendly User Location Tracking with Smart Devices: The BeaT Prototype Application-oriented robotics in nursing homes Augmented Reality for Set-up Processe Mixed Reality for supporting Remote-Meetings Gamification zur Motivationssteigerung von Werkern bei der Betriebsdatenerfassung Automatically Extracting and Analyzing Customer Needs from Twitter: A “Needmining” Prototype GaNEsHA: Opportunities for Sustainable Transportation in Smart Cities TUCANA: A platform for using local processing power of edge devices for building data-driven services Demonstrator zur Beschreibung und Visualisierung einer kritischen Infrastruktur Entwicklung einer alltagsnahen persuasiven App zur Bewegungsmotivation für ältere Nutzerinnen und Nutzer A browser-based modeling tool for studying the learning of conceptual modeling based on a multi-modal data collection approach Exergames & Dementia: An interactive System for People with Dementia and their Care-Network Workshops Workshop Ethics and Morality in Business Informatics (Workshop Ethik und Moral in der Wirtschaftsinformatik – EMoWI’19) Model-Based Compliance in Information Systems - Foundations, Case Description and Data Set of the MobIS-Challenge for Students and Doctoral Candidates Report of the Workshop on Concepts and Methods of Identifying Digital Potentials in Information Management Control of Systemic Risks in Global Networks - A Grand Challenge to Information Systems Research Die Mitarbeiter von morgen - Kompetenzen künftiger Mitarbeiter im Bereich Business Analytics Digitaler Konsum: Herausforderungen und Chancen der Verbraucherinformati

Improved upper limb function in non-ambulant children with SMA type 2 and 3 during nusinersen treatment: a prospective 3-years SMArtCARE registry study

Background The development and approval of disease modifying treatments have dramatically changed disease progression in patients with spinal muscular atrophy (SMA). Nusinersen was approved in Europe in 2017 for the treatment of SMA patients irrespective of age and disease severity. Most data on therapeutic efficacy are available for the infantile-onset SMA. For patients with SMA type 2 and type 3, there is still a lack of sufficient evidence and long-term experience for nusinersen treatment. Here, we report data from the SMArtCARE registry of non-ambulant children with SMA type 2 and typen 3 under nusinersen treatment with a follow-up period of up to 38 months. Methods SMArtCARE is a disease-specific registry with data on patients with SMA irrespective of age, treatment regime or disease severity. Data are collected during routine patient visits as real-world outcome data. This analysis included all non-ambulant patients with SMA type 2 or 3 below 18 years of age before initiation of treatment. Primary outcomes were changes in motor function evaluated with the Hammersmith Functional Motor Scale Expanded (HFMSE) and the Revised Upper Limb Module (RULM). Results Data from 256 non-ambulant, pediatric patients with SMA were included in the data analysis. Improvements in motor function were more prominent in upper limb: 32.4% of patients experienced clinically meaningful improvements in RULM and 24.6% in HFMSE. 8.6% of patients gained a new motor milestone, whereas no motor milestones were lost. Only 4.3% of patients showed a clinically meaningful worsening in HFMSE and 1.2% in RULM score. Conclusion Our results demonstrate clinically meaningful improvements or stabilization of disease progression in non-ambulant, pediatric patients with SMA under nusinersen treatment. Changes were most evident in upper limb function and were observed continuously over the follow-up period. Our data confirm clinical trial data, while providing longer follow-up, an increased number of treated patients, and a wider range of age and disease severity