Randomized Trial on the Effectiveness of Dexamethasone in TMJ Arthrocentesis

The aim of this study was to compare the effectiveness of dexamethasone administration following arthrocentesis of the temporomandibular joint (TMJ) with a placebo (saline). Twenty-eight participants with TMJ arthralgia were randomly assigned to two groups of a parallel double-blind RCT. In both groups, an arthrocentesis procedure was carried out. In one group, the procedure was followed by the administration of a single-dose intra-articular dexamethasone. In the other group, saline was administered as a control. Follow-up visits were scheduled after 1, 3, and 24 weeks. During each visit, TMJ pain (on a 100-mm VAS) and jaw stiffness (mouth opening in mm) were scored. In the statistical analysis, generalized estimating equation (GEE) models showed no differences between the two study groups, although pain and jaw stiffness were both reduced over 24 weeks. In conclusion, intra-articular dexamethasone following arthrocentesis did not improve the procedure's effect in patients presenting with TMJ arthralgia (ClinicalTrials.gov number CT01275014)

Counterexamples to the discrete and continuous weighted Weiss conjectures

Counterexamples are presented to weighted forms of the Weiss conjecture in discrete and continuous time. In particular, for certain ranges of $\alpha$, operators are constructed that satisfy a given resolvent estimate, but fail to be $\alpha$-admissible. For $\alpha \in (-1,0)$ the operators constructed are normal, while for $\alpha \in (0,1)$ the operator is the unilateral shift on the Hardy space $H^2(\mathbb{D})$.Comment: 16 page