Promene faringealnih vazdušnih puteva nakon monomaksilarne ortognatske hirurgije

Introduction/Objective Maxillary or mandibular retrognathism are common dentofacial deformities treated by combined orthodontic-surgical treatment. Surgical maxillary or mandibular advancement changes the position and strain of surrounding structures, which may also affect pharyngeal airway dimensions. The aim of this study was to evaluate and compare three-dimensional pharyngeal airway space changes in patients treated with maxillary advancement and those treated with mandibular advancement. Methods The sample consisted of 25 patients - 12 treated with maxillary advancement and 13 with mandibular advancement surgery. Nasopharyngeal (NP) volume, oropharyngeal (OP) volume, and the area of maximum constriction (AMC) in the OP were measured on cone beam computed tomography scans (2 mA / 120 kV / 12'' FOV) taken before and at least three months after surgery. Paired samples t-test was used for analyzing statistical significance of changes (p ≤ 0.05). Results Postoperative OP and NP volumes, as well as the AMC, increased insignificantly in both groups. Conclusion Results suggest that mono-maxillary surgical advancement of the maxilla or the mandible increases pharyngeal airway dimensions.Uvod/Cilj Retrognatizam gornje vilice i retrognatizam donje vilice su česti dentofacijalni deformiteti, koji se leče kombinovanom ortodontsko-hirurškom terapijom. Hirurško pomeranje gornje ili donje vilice unapred menja položaj i napetost okolnih struktura, što takođe utiče na dimenzije faringealnih vazdušnih puteva. Cilj istraživanja bio je da se procene i uporede trodimenzionalne promene faringealnih vazdušnih puteva kod bolesnika lečenih hirurškim pomeranjem gornje ili donje vilice unapred. Metode Uzorak istraživanja se sastojao od 25 bolesnika 12 lečenih hirurškim pomeranjem gornje vilice i 13 lečenih hirurškim pomeranjem donje vilice unapred. Zapremine nazofarinksa i orofarinksa i površine najužeg dela farinksa su merene na CBCT snimcima (2 mA / 120 kV / 12'' FOV) napravljenim pre i bar tri meseca posle hirurške korekcije. Studentov t-test za uparene uzorke je korišćen za analizu statističke značajnosti promena (p ≤ 0,05). Rezultati Zapremine nazofarinksa i orofarinksa i površine najužeg dela farinka povećale su se posle hirurškog pomeranja gornje ili donje vilice unapred. Statistička značajnost nije zabeležena. Zaključak Rezultati ukazuju na to da hirurško pomeranje gornje ili donje vilice unapred dovodi do povećanja dimenzija faringealnih vazdušnih puteva

The bioarchaeology of the Neolithic transition: evidence of dental pathologies at Lepenski Vir (Serbia)

The Neolithic transition affected human biology, which is visible as a series of interrelated skeletal and dental pathological conditions. The population of Lepenski vir culture, which inhabited the region of the Danube Gorges between 9500-5500 BC, also went through the neolithisation process. In this study, the dental pathological conditions of 32 adult individuals from the Lepenski Vir site were examined for the incidence of enamel hypoplasia, the rate of dental wear, dental caries and ante-mortem tooth loss. The results indicate changes in biology and diet of this population in the Neolithic which were associated with the introduction of non-local identities in the region

Possible Therapeutic Use of Spermatogonial Stem Cells in the Treatment of Male Infertility: A Brief Overview

Development of germ cells is a process starting in fetus and completed only in puberty. Spermatogonial stem cells maintain spermatogenesis throughout the reproductive life of mammals. They are undifferentiated cells defined by their ability to both self-renew and differentiate into mature spermatozoa. This self-renewal and differentiation in turn is tightly regulated by a combination of intrinsic gene expression as well as the extrinsic gene signals from the local tissue microenvironment. The human testis is prone to damage, either for therapeutic reasons or because of toxic agents from the environment. For preservation of fertility, patients who will undergo radiotherapy and/or chemotherapy have an attractive possibility to keep in store and afterwards make a transfer of spermatogonial stem cells. Germ cell transplantation is not yet ready for the human fertility clinic, but it may be reasonable for young cancer patients, with no other options to preserve their fertility. Whereas this technique has become an important research tool in rodents, a clinical application must still be regarded as experimental, and many aspects of the procedure need to be optimized prior to a clinical application in men. In future, a range of options for the preservation of male fertility will get a new significance

Mechanical properties and morphology of the poly(urethane-siloxane) copolymers and their clay nanocomposites

In this paper the series of poly(urethane-siloxane) copolymers and their clay nanocomposites were synthesized based on 4,4'-diphenylmethane diisocyanate and 1,4-butanediol as the part of the hard segments (HS) and α,ω-dihydroxy-poly(propyleneoxide)-b-poly(dimethylsiloxane)-b-poly(propylene oxide) as the part of the soft segments (SS). Organomodified montmorillonite clay (Cloisite 30B®) was used as nanofiller in the amount of 1 wt.% within prepared nanocomposites. Mechanical properties and morphology of these polymers were investigated by dynamic mechanical thermal analysis (DMTA) and wide angle X-ray diffraction (XRD) measurements

Асоцијативни речник српског језика

Pierwsza część słownika asocjacyjnego języka serbskiego

Desirable attributes of an effective intelligence analyst

The role of analytics in business and intelligence communities is more important than ever. The process of analyzing and evaluating a large quantity of data, as well as finding relations, trends, patterns and correlations is very complex. Processing a great amount of information and evaluating its reliability represents an additional problem. Bearing this in mind, preparing analysis is extremely difficult and requires high attention, trained personnel and application of modern scientific methods and techniques

Implementation of Urban Solution for New Faculty Facilities within Spatial Historical and Cultural Units—A Case Study of Belgrade, Serbia

The focus of this study is buildings for public purposes, specifically for higher education, planned in zones of spatial cultural-historical units. Sustainable urban planning in areas with cultural-historical heritage is a particular challenge since the higher education facilities themselves have their own functional requirements, which are much easier to fulfill in “softer” locations. The research objective is to prove the hypothesis that it is possible to indicate a prescription for the practical application of the theoretical model and define the necessary steps to achieve the best sustainable quality results in practice. The paper analyses the associated process, relational settings, circumstances, participants, and timelines, and it presents the results of final designs based on two parallel case studies of new capital buildings for the University of Belgrade. Methodologically it gives an overview of the context, referring to other research and examples, detailing chosen case studies, and describing their backgrounds, conditions and requirements, frameworks, chronologies, approaches, and results. The discussion concludes with theoretical models originating from the comparison of implemented steps in the process of creation and evaluation of architectural ideas and summarized similarities and differences, aiming that there is a common model suitable for further applications. The practical result of the research is findings about the pathway for the best original planning solution emphasized through the institution of urban architectural competitions as a mandatory step, recommending wider participation of experts in the process of evaluation.Special Issue "The Role of Cultural Heritage in Promoting the Sustainable Development of Cities and Territories" Academic Editors: Francesco Rotondo, Giovanna Mangialardi, Mariella Annese and Choongwan Ko

Нанокомпозити на бази термопластичног линеарног поли(уретан-силоксан)а и органоглине: утицај састава на својства

Thermoplastic poly(urethane-siloxane)/organoclay nanocomposites (TPU NCs) with different hard segment content (20–55 wt. %) were prepared by in situ polymerization in the presence of organically modified montmorillonite as a nanofiller (Cloisite 30B; 1 wt. %). Hydroxyl-terminated ethoxypropyl- poly(dimethylsiloxane) was used as soft segment, while 4,4'-methylenediphenyl diisocyanate and 1,4-butanediol were the hard segment components. The study of the influence of the hard segment content on the functional properties of TPU NCs was performed by Fourier transform infrared (FTIR) spectroscopy, X-ray diffractometry (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), dynamic mechanical thermal analyses (DMTA), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), water contact angle and water absorption tests. The results revealed that TPU NCs with the increasing hard segment content exhibit higher values of degree of microphase separation, melting temperature of the hard segments, degree of crystallinity, storage modulus (except for TPU NC-55), but lower thermal stability and hydrophobicity. TPU NC films were hydrophobic and their free surface energy was in the range from 17.7 to 24.9 mJ m-2. This work highlights how the composition of TPU NCs would affect their functional properties and provide an additional composition intended for designing advanced TPU NC materials for special biomedical applications.Термопластични поли(уретан-силоксан)/органоглина нанокомпозити (TPU NCs) са различитим садржајем тврдих сегмената (20–55 теж. %) припремљени су in situ полимеризацијом у присуству органски модификованог монтморилонита као нанопуниoца (Cloisite 30B; 1 теж. %). Као меки сегмент коришћен је хидроксиетоксипропил терминирани поли(диметилсилоксан), а као компоненте тврдог сегмента коршћени су 4,4'- -метилендифенилдиизоцијанат и 1,4-бутандиол. Проучавање утицаја садржаја тврдог сегмента на функционална својства TPU NCs је испитивано FTIR спектроскопијом, дифракцијом X-зрака (XRD), микроскопијом атомских сила (AFM), скенирајућом електронском микроскопијом (SEM), динамичко механичко термичком анализом (DMTA), диференцијално скенирајућом калориметријом (DSC), термогравиметријском анализом (TGA), тестовима одређивања контактног угла са водом и апсорпције воде. Резултати су показали да TPU NCs са већим садржајем тврдих сегмената показују веће вредности степена микрофазне сепарације, температуре топљења тврдих сегмената, степена кристалиничности, модула сачуване енергије (осим за TPU NC-55), али нижу термичку стабилност и хидрофобност. TPU NC филмови су били хидрофобни и њихова површинска енергија је била у опсегу од 17,7 до 24,9 mJ m-2. Овај рад истиче како би се променом састава у TPU NCs подешавала функционална својства и обезбедило додатно подешавање састава за дизајнирање напредних TPU NC материјала за специјалне биомедицинске примене

Terapijski efekti tri vrste funkcionalnih aparata u lečenju malokluzija II skeletne klase - sagitalne i vertikalne promene

Introduction/Objective Class II malocclusions are sagittal malocclusions characterized by a distal relationship of posterior teeth. Depending on the underlying problem, Class II malocclusions can be skeletal or dentoalveolar. Class II malocclusion treatment modality will depend on the cause, severity, and age. Growth modification is the best treatment option in growing patients with skeletal Class II malocclusions. The aim of this study was to establish and compare sagittal and vertical skeletal and dental changes in patients treated with the 'M block' appliance, the Frankel functional regulator, and the Balters' bionator. Methods The sample consisted of 70 patients diagnosed with skeletal Class II malocclusions (ANB > 4°) and mandibular retrognathism (SNB lt 80°). The patients were divided into three groups according to the type of appliance. All the patients went through the standard diagnostic procedure (anamnesis, clinical and functional analysis, study model, panoramic radiograph, and cephalometric analysis), and dental and skeletal age was determined. Treatment effects were analyzed on study models and cephalograms at the end of treatment. Results All the appliances led to significant mandibular anterior movement and sagittal growth, which reduced the ANB values. All three groups of patients presented with neutral growth pattern, upper incisor retrusion, and lower incisor protrusion at the end of treatment. Conclusion The results of this study indicate efficacy of all three appliances in skeletal Class II malocclusion treatment.Uvod/Cilj rada Malokluzije II klase su sagitalne nepravilnosti zagrižaja koje karakteriše distalni odnos bočnih zuba. U zavisnosti od toga koje strukture su u nepravilnom odnosu, dele se na skeletne i dentoalveolarne. Terapija II klase zavisi od uzroka, izraženosti i uzrasta. Najbolji vid terapije ukoliko pacijenti i dalje rastu je modifikacija rasta. Cilj ove studije bio je da se utvrde i uporede sagitalne i vertikalne promene na skeletnim i dentalnim strukturama u toku lečenja M blok-aparatom, Frenklovim regulatorom funkcije tip I i bionatorom po Baltersu tip I. Metode Sedamdeset ispitanika sa dijagnozom skeletnog distalnog zagrižaja (ANB > 4°) i mandibularnog retrognatizma (SNB lt 80°), prema vrsti aparata, podeljeni su u tri grupe. Svi su prošli kroz standardnu dijagnostiku (anamneza, klinička i funkcionalna analiza, analiza studijskih modela, ortopantomografskog i profilnog telerendgenskog snimka). Terapijski efekti i promene analizirani su na studijskim modelima i profilnom snimcima po završetku terapije. Rezultati Sva tri aparata dovela su do značajnog mezijalnog usmeravanja i sagitalnog rasta mandibule, što je smanjilo ANB ugao. U sve tri grupe je utvrđen neutralni rast, kao i retruzija gornjih i protruzija donjih sekutića. Zaključak Rezultati studije ukazuju na efikasnost sva tri ispitivana aparata u lečenju skeletnih malokluzija II klase