Instrument, Method, Brightness and Polarization Maps from the 2003 flight of BOOMERanG

We present the BOOMERanG-03 experiment and maps of the Stokes parameters I, Q, U of the microwave sky obtained during a 14 day balloon flight in 2003. Three regions of the southern sky were surveyed: a deep survey (~ 90 square degrees) and a shallow survey (~ 750 square degrees) at high Galactic latitudes (both centered at RA ~ 5.5 h, dec ~ -45 deg) and a survey of ~ 300 square degrees across the Galactic plane at RA ~ 9.1 h, dec ~ -47 deg. All three surveys were carried out in three wide frequency bands centered at 145, 245 and 345 GHz, with an angular resolution of ~ 10'. The 145 GHz maps of Stokes I are dominated by Cosmic Microwave Background (CMB) temperature anisotropy, which is mapped with high signal to noise ratio. The measured anisotropy pattern is consistent with the pattern measured in the same region by BOOMERanG-98 and by WMAP. The 145 GHz maps of Stokes Q and U provide a robust statistical detection of polarization of the CMB when subjected to a power spectrum analysis. This amplitude of the polarization is consistent with that of the CMB in the $\Lambda$CDM cosmological scenario. At 145 GHz, in the CMB surveys, the intensity and polarization of the astrophysical foregrounds are found to be negligible with respect to the cosmological signal. At 245 and 345 GHz we detect ISD emission correlated to the 3000 GHz IRAS/DIRBE maps, and give upper limits for any other non-CMB component. We also present intensity maps of the surveyed section of the Galactic plane. These are compared to monitors of different interstellar components, showing that a variety of emission mechanisms is present in that region.Comment: see http://oberon.roma1.infn.it/boomerang/b2k and http://cmb.phys.cwru.edu/boomerang/ for a high resolution versio

Estimating epsilon'/epsilon. A Review

The real part of epsilon'/epsilon measures direct CP violation in the decays of the neutral kaons in two pions. It is a fundamental quantity which has justly attracted a great deal of theoretical as well as experimental work. Its determination may answer the question of whether CP violation is present only in the mass matrix of neutral kaons (the superweak scenario) or also at work directly in the decays. After a brief historical summary, we discuss the present and expected experimental sensitivities. In the light of these, we come to the problem of estimating epsilon'/epsilon in the standard model. We review the present (circa 1998) status of the theoretical predictions of epsilon'/epsilon. The short-distance part of the computation is now known to the next-to-leading order in QCD and QED and therefore well under control. On the other hand, the evaluation of the hadronic matrix element of the relevant operators is where most of the theoretical uncertainty still resides. We analyze the results of the currently most developed calculations. The values of the B_i parameters in the various approaches are discussed, together with the allowed range of the relevant combination of the Cabibbo-Kobayashi-Maskawa entries Im V_{td}V^*_{ts}. We conclude by summarizing and comparing all up-to-date predictions of epsilon'/epsilon. Because of the intrinsic uncertainties of the long-distance computations, values ranging from 10^{-4} to a few times 10^{-3} can be accounted for in the standard model. Since this range covers most of the present experimental uncertainty, it is unlikely that new physics effects can be disentangled from the standard model prediction. For updates on the review and additional material see http://www.he.sissa.it/review/.Comment: 42 pages, 13 figures. To appear in Reviews of Modern Physic

Clinical Features, Cardiovascular Risk Profile, and Therapeutic Trajectories of Patients with Type 2 Diabetes Candidate for Oral Semaglutide Therapy in the Italian Specialist Care

Introduction: This study aimed to address therapeutic inertia in the management of type 2 diabetes (T2D) by investigating the potential of early treatment with oral semaglutide. Methods: A cross-sectional survey was conducted between October 2021 and April 2022 among specialists treating individuals with T2D. A scientific committee designed a data collection form covering demographics, cardiovascular risk, glucose control metrics, ongoing therapies, and physician judgments on treatment appropriateness. Participants completed anonymous patient questionnaires reflecting routine clinical encounters. The preferred therapeutic regimen for each patient was also identified. Results: The analysis was conducted on 4449 patients initiating oral semaglutide. The population had a relatively short disease duration (42%  60% of patients, and more often than sitagliptin or empagliflozin. Conclusion: The study supports the potential of early implementation of oral semaglutide as a strategy to overcome therapeutic inertia and enhance T2D management

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

"Victorian Romantics", numero monografico de "La Questione Romantica", vol. 5, n. 1-2 (gennaio-dicembre 2013) [ma 2015].

The title of this special issue of "La Questione Romantica" is deliberately ambiguous as it might be understood in two different ways: on the one hand, it stresses the survival of Romantic features within Victorian literary culture (that is, exploring the extent to which the Victorians themselves might be considered ‘Romantic’); or, on the other, it may refer to ways in which the Victorian reception of Romantic authors, ideas and genres has made the Romantics themselves appear Victorian over the course of time. Although distinct, these two modes of survival are almost inextricably intertwined. This collection of essays intends to provide new insights into bot

Anatomical eligibility of the renal vasculature for catheter-based renal denervation in hypertensive patients.

OBJECTIVES This study sought to determine the vascular anatomical eligibility for catheter-based renal artery denervation (RDN) in hypertensive patients. BACKGROUND Arterial hypertension is the leading cardiovascular risk factor for stroke and mortality globally. Despite substantial advances in drug-based treatment, many patients do not achieve target blood pressure levels. To improve the number of controlled patients, novel procedure- and device-based strategies have been developed. RDN is among the most promising novel techniques. However, there are few data on the vascular anatomical eligibility. METHODS We retrospectively analyzed 941 consecutive hypertensive patients undergoing coronary angiography and selective renal artery angiography between January 1, 2010, and May 31, 2012. Additional renal arteries were divided into 2 groups: hilar (accessory) and polar (aberrant) arteries. Anatomical eligibility for RDN was defined according to the current guidelines: absence of renal artery stenosis, renal artery diameter ≥4 mm, renal artery length ≥20 mm, and only 1 principal renal artery. RESULTS A total of 934 hypertensive patients were evaluable. The prevalence of renal artery stenosis was 10% (n = 90). Of the remaining 844 patients without renal artery stenosis, 727 (86%) had nonresistant hypertension and 117 (14%) had resistant hypertension; 62 (53%) of the resistant hypertensive and 381 (52%) of the nonresistant hypertensive patients were anatomically eligible for sympathetic RDN. CONCLUSIONS The vascular anatomical eligibility criteria of the current guidelines are a major limiting factor for the utilization of RDN as a therapeutic option. Development of new devices and/or techniques may significantly increase the number of candidates for these promising therapeutic options

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals

The microsomal enzyme acyl-CoA:cholesterol acyltransferase (ACAT; EC 2.3.1.26) catalyzes the esterification of cellular cholesterol with fatty acids to form cholesterol esters. ACAT activity is found in many tissues, including macrophages, the adrenal glands, and the liver. In macrophages, ACAT is thought to participate in foam cell formation and thereby to contribute to atherosclerotic lesion development. Disruption of the gene for ACAT (Acact) in mice resulted in decreased cholesterol esterification in ACAT-deficient fibroblasts and adrenal membranes, and markedly reduced cholesterol ester levels in adrenal glands and peritoneal macrophages; the latter finding will be useful in testing the role of ACAT and macrophage foam cell formation in atherosclerosis. In contrast, the livers of ACAT-deficient mice contained substantial amounts of cholesterol esters and exhibited no reduction in cholesterol esterification activity. These tissue-specific reductions in cholesterol esterification provide evidence that in mammals this process involves more than one form of esterification enzyme

TGF-β Modulated Pathways in Colorectal Cancer: New Potential Therapeutic Opportunities

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with 20% of patients presenting with metastatic disease at diagnosis. TGF-β signaling plays a crucial role in various cellular processes, including growth, differentiation, apoptosis, epithelial-mesenchymal transition (EMT), regulation of the extracellular matrix, angiogenesis, and immune responses. TGF-β signals through SMAD proteins, which are intracellular molecules that transmit TGF-β signals from the cell membrane to the nucleus. Alterations in the TGF-β pathway and mutations in SMAD proteins are common in metastatic CRC (mCRC), making them critical factors in CRC tumorigenesis. This review first analyzes normal TGF-β signaling and then investigates its role in CRC pathogenesis, highlighting the mechanisms through which TGF-β influences metastasis development. TGF-β promotes neoangiogenesis via VEGF overexpression, pericyte differentiation, and other mechanisms. Additionally, TGF-β affects various elements of the tumor microenvironment, including T cells, fibroblasts, and macrophages, promoting immunosuppression and metastasis. Given its strategic role in multiple processes, we explored different strategies to target TGF-β in mCRC patients, aiming to identify new therapeutic options

Intraoperative lung ultrasound improves subcentimetric pulmonary nodule localization during VATS: Results of a retrospective analysis

Abstract Background Video‐assisted thoracoscopic surgery (VATS) resection of deep‐seated lung nodules smaller than 1 cm is extremely challenging. Several methods have been proposed to overcome this limitation but with not neglectable complications. Intraoperative lung ultrasound (ILU) is the latest minimally invasive proposed technique. The aim of the current study was to analyze the accuracy and efficacy of ILU associated with VATS to visualize solitary and deep‐seated pulmonary nodules smaller than 1 cm. Methods Patients with subcentimetric solitary and deep‐seated pulmonary nodules were included in this retrospective study from November 2020 to December 2022. Patients who received VATS aided with ILU were considered as group A and patients who received conventional VATS as group B (control group). The rate of nodule identification and the time for localization with VATS alone and with VATS aided with ILU in each group were analyzed. Results A total of 43 patients received VATS aided with ILU (group A) and 31 patients received conventional VATS (group B). Mean operative time was lower in group A (p < 0.05). In group A all the nodules were correctly identified, while in group B in one case the localization failed. The time to identify the lesion was lower in group A (7.1 ± 2.2 vs. 13.8 ± 4.6; p < 0.05). During hospitalization three patients (6.5%; p < 0.05) in group B presented air leaks that were conservatively managed. Conclusion Intracavitary VATS‐US is a reliable, feasible, real‐time and effective method of localization of parenchymal lung nodules during selected wedge resection procedures