Advanced strategies for characterizing molecular imprinted polymers

In order to fully realize the potential of MIPs within applications where the speed of binding and the dynamics of the binding process are essential (e.g. chem/bio sensing), it is important that MIP characterization reproducibly covers both dynamic/kinetic performance and equilibrium behaviour, ideally via transferable and unified analysis protocols applicable to all kinds of MIPs. Consequently, a more detailed analysis of the post-synthesis treatment of MIPs is necessary to evaluate and fundamentally understand the potential of MIPs serving as adsorbing media correctly, which summarizes the motivation for the studies performed within this thesis. Advanced strategies were developed for the treatment of MIPs immediately after the synthesis of the polymer by introducing innovative clean-up methods ensuring a more exhaustive extraction of template and impurities prior to the analysis of the polymer. For obtaining equilibrium and kinetic data on thus synthesized MIPs and NIPs, a flow-cell-based setup was developed, and a theoretical basis facilitating the understanding on equilibrium and kinetic data was developed. Furthermore, high-throughput methods for the generation of sufficient quantities of equilibrium binding data have been investigated along with potential problems and limitations occurring during the comparison of different experimental methods. Finally, this thesis is concluded with a proposed redefinition of one of the key parameters commonly used during MIP/NIP evaluation - the so-called imprinting factor - to more precisely render the significance of this figure of merit

W-Lisp Sprachbeschreibung

W-Lisp [Wippennann 91] ist eine Sprache, die im Bereich der Implementierung höherer Programmiersprachen verwendet wird. Ihre Anwendung ist nicht auf diesen Bereich beschränkt. Gute Lesbarkeit der W-Lisp-Notation wird durch zahlreiche Anleihen aus dem Bereich der bekannten imperativen Sprachen erzielt. W-Lisp-Programme können im Rahmen eines Common Lisp-Systems ausgeführt werden. In der WLisp Notation können alle Lisp-Funktionen (inkl. MCS) verwendet werden, so daß die Mächtigkeit von Common-Lisp [Steele 90] in dieser Hinsicht auch in W-Lisp verfügbar ist

Die geringe Hebelwirkung von Personalentwicklung. Ein Diskussionsbeitrag

Kühl S. Die geringe Hebelwirkung von Personalentwicklung. Ein Diskussionsbeitrag. In: Eppler MJ, ed. HR - Schlüssel zum Change? Wie das Personalmanagement sich jetzt positionieren sollte. OrganisationsEntwicklung - Dossier. Vol 2. Düsseldorf: Verl.-Gruppe Handelsblatt; 2012: 14-17

W-Lisp Sprachbeschreibung

W-Lisp [Wippennann 91] ist eine Sprache, die im Bereich der Implementierung höherer Programmiersprachen verwendet wird. Ihre Anwendung ist nicht auf diesen Bereich beschränkt. Gute Lesbarkeit der W-Lisp-Notation wird durch zahlreiche Anleihen aus dem Bereich der bekannten imperativen Sprachen erzielt. W-Lisp-Programme können im Rahmen eines Common Lisp-Systems ausgeführt werden. In der WLisp Notation können alle Lisp-Funktionen (inkl. MCS) verwendet werden, so daß die Mächtigkeit von Common-Lisp [Steele 90] in dieser Hinsicht auch in W-Lisp verfügbar ist

An atypical lateral hernia and concomitant inguinal and umbilical hernias in a patient with polycystic kidney disease and an intracranial aneurysm – a combined approach of clinical and radiological investigation, endoscopic hernia repair, and anatomical cadaver model documentation and a systematic review of the literature

Atypical hernias are difficult to diagnose due to their rarity and often unspecific symptoms. In the literature there exist hints to peri-inguinal hernias, i.e. direct lateral hernia, but most of them are forms of Spigelian hernias. Since the majority were described during the first half of the past century or even earlier, only very few cases have been documented using modern diagnostic techniques. We report a unique case of a 51 year old patient presenting with an atypical inguinal hernia with concomitant inguinal and umbilical hernias in combination with cystic kidney disease and intracranial aneurysm. The atypical position of the hernia was assumed from clinical inspection, ultrasound and CT scan and verified during pre-peritoneoscopy. Using an anatomical cadaver dissection approach, we followed the unusual position of the hernia through the abdominal wall below the aponeurosis of the external oblique muscle. After a thorough literature search, we assume that the present hernia containing a hernial sac has not been documented before, especially not in such a multidisciplinary approach comprising radiological, surgical and anatomical localisation and endoscopic treatment in a patient with a clinical situation being aggravated by large cystic kidneys leading to dialysis-dependency. Rare hernias have been described as being often associated with concomitant inguinal or other hernias, a predisposition for the male gender and a pathogenic mechanism related to other soft tissue defects such as cystic kidney disease or cranial aneurysm. Thus, we consider this a unique case that has not been documented in this constellation previously, which may increase the awareness for these rare hernias

Synthesis, Chiral Resolution, and Absolute Configuration of Dissymmetric 4,15-Difunctionalized [2.2]Paracyclophanes

Despite the fact that functionalized planar chiral [2.2]­paracyclophanes have received a lot of attention, the chemistry of pseudo-<i>meta</i> 4,15-distubstituted [2.2]­paracyclophanes is largely unexplored. This is mainly due to the fact that the 4,5-dibromo-functionalized [2.2]­paracyclophane is much less prone to halogen-metal exchange reactions than its constitutional pseudo-<i>ortho</i> or pseudo-<i>para</i> isomers. Here, we give an account of an efficient protocol to achieve this, which allows the synthesis of a broad variety of 4,15-disubstituted [2.2]­paracyclophanes. Furthermore, we were able to resolve several of the racemic compounds via chiral HPLC and assign the absolute configurations of the isolated enantiomers by X-ray diffraction and/or by the comparison of calculated and measured CD-spectra