4 research outputs found
The use of small volume TOC analysis as complementary, indispensable tool in the evaluation of photocatalysts at lab-scale
No full text<tex>\_alpha$</tex>-ketoheterocycles as inhibitors of **Leishmania mexicana** cysteine protease CPB
No full textDipeptidyl α-fluorovinyl Michael acceptors: Synthesis and activity against cysteine protease
No full textThe synthesis of novel dipeptidyl α-fluorovinyl sulfones using a Horner–Wadsworth–Emmons approach on N-Boc-l-phenylalaninal is described. Inhibitory assays against a Leishmania mexicana cysteine protease (CPB2.8ΔCTE) revealed low biological activity. Relative rates of Michael additions of 2′-(phenethyl)thiol with vinyl sulfone and α-fluorovinyl sulfone were determined, and ab initio calculations on several Michael acceptor model structures were performed; both were in agreement with the biological testing
