11,110 research outputs found

    Photoionization and Photoelectric Loading of Barium Ion Traps

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    Simple and effective techniques for loading barium ions into linear Paul traps are demonstrated. Two-step photoionization of neutral barium is achieved using a weak intercombination line (6s2 1S0 6s6p 3P1, 791 nm) followed by excitation above the ionization threshold using a nitrogen gas laser (337 nm). Isotopic selectivity is achieved by using a near Doppler-free geometry for excitation of the triplet 6s6p 3P1 state. Additionally, we report a particularly simple and efficient trap loading technique that employs an in-expensive UV epoxy curing lamp to generate photoelectrons.Comment: 5 pages, Accepted to PRA 3/20/2007 -fixed typo -clarified figure 3 caption -added reference [15

    Transillumination imaging through scattering media by use of photorefractive polymers

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    We demonstrate the use of a near-infrared-sensitive photorefractive polymer with high efficiency for imaging through scattering media, using an all-optical holographic time gate. Imaging through nine scattering mean free paths is performed at 800 nm with a mode-locked continuous-wave Ti:sapphire laser

    Discovery of extended radio emission in the young cluster Wd1

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    We present 10 micron, ISO-SWS and Australia Telescope Compact Array observations of the region in the cluster Wd1 in Ara centred on the B[e] star Ara C. An ISO-SWS spectrum reveals emission from highly ionised species in the vicinity of the star, suggesting a secondary source of excitation in the region. We find strong radio emission at both 3.5cm and 6.3cm, with a total spatial extent of over 20 arcsec. The emission is found to be concentrated in two discrete structures, separated by 14''. The westerly source is resolved, with a spectral index indicative of thermal emission. The easterly source is clearly extended and nonthermal (synchrotron) in nature. Positionally, the B[e] star is found to coincide with the more compact radio source, while the southerly lobe of the extended source is coincident with Ara A, an M2 I star. Observation of the region at 10micron reveals strong emission with an almost identical spatial distribution to the radio emission. Ara C is found to have an extreme radio luminosity in comparison to prior radio observations of hot stars such as O and B supergiants and Wolf-Rayet stars, given the estimated distance to the cluster. An origin in a detatched shell of material around the central star is therefore suggested; however given the spatial extent of the emission, such a shell must be relatively young (10^3 yrs). The extended non thermal emission associated with the M star Ara A is unexpected; to the best of our knowledge this is a unique phenomenon. SAX (2-10keV) observations show no evidence of X-ray emission, which might be expected if a compact companion were present.Comment: 5 pages including encapsulated figures, figure 3 separate. Accepted for MNRAS pink page

    Semaphorin-plexin signaling: From axonal guidance to a new X-linked intellectual disability syndrome

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    BACKGROUND: Semaphorins and plexins are ligands and cell surface receptors that regulate multiple neurodevelopmental processes such as axonal growth and guidance. PLXNA3 is a plexin gene located on the X chromosome that encodes the most widely expressed plexin receptor in fetal brain, plexin-A3. Plexin-A3 knockout mice demonstrate its role in semaphorin signaling in vivo. The clinical manifestations of semaphorin/plexin neurodevelopmental disorders have been less widely explored. This study describes the neurological and neurodevelopmental phenotypes of boys with maternally inherited hemizygous PLXNA3 variants. METHODS: Data-sharing through GeneDx and GeneMatcher allowed identification of individuals with autism or intellectual disabilities (autism/ID) and hemizygous PLXNA3 variants in collaboration with their physicians and genetic counselors, who completed questionnaires about their patients. In silico analyses predicted pathogenicity for each PLXNA3 variant. RESULTS: We assessed 14 boys (mean age, 10.7 [range 2 to 25] years) with maternally inherited hemizygous PLXNA3 variants and autism/ID ranging from mild to severe. Other findings included fine motor dyspraxia (92%), attention-deficit/hyperactivity traits, and aggressive behaviors (63%). Six patients (43%) had seizures. Thirteen boys (93%) with PLXNA3 variants showed novel or very low allele frequencies and probable damaging/disease-causing pathogenicity in one or more predictors. We found a genotype-phenotype correlation between PLXNA3 cytoplasmic domain variants (exons 22 to 32) and more severe neurodevelopmental disorder phenotypes (P \u3c 0.05). CONCLUSIONS: We report 14 boys with maternally inherited, hemizygous PLXNA3 variants and a range of neurodevelopmental disorders suggesting a novel X-linked intellectual disability syndrome. Greater understanding of PLXNA3 variant pathogenicity in humans will require additional clinical, computational, and experimental validation

    Mass Predictions for Pseudoscalar JPC=0−+J^{PC}=0^{-+} Charmonium and Bottomonium Hybrids in QCD Sum-Rules

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    Masses of the pseudoscalar (JPC=0−+)(J^{PC}=0^{-+}) charmonium and bottomonium hybrids are determined using QCD Laplace sum-rules. The effects of the dimension-six gluon condensate are included in our analysis and result in a stable sum-rule analysis, whereas previous studies of these states were unable to optimize mass predictions. The pseudoscalar charmonium hybrid is predicted to have a mass of approximately 3.8 GeV and the corresponding bottomonium prediction is 10.6 GeV. Calculating the full correlation function, rather than only the imaginary part, is shown to be necessary for accurate formulation of the sum-rules. The charmonium hybrid mass prediction is discussed within the context of the X Y Z resonances.Comment: 10 pages, 7 embedded figures. Analysis extended and refined in v
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