287 research outputs found

    The Yersinia pestis gcvB gene encodes two small regulatory RNA molecules

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    BACKGROUND: In recent years it has become clear that small non-coding RNAs function as regulatory elements in bacterial virulence and bacterial stress responses. We tested for the presence of the small non-coding GcvB RNAs in Y. pestis as possible regulators of gene expression in this organism. RESULTS: In this study, we report that the Yersinia pestis KIM6 gcvB gene encodes two small RNAs. Transcription of gcvB is activated by the GcvA protein and repressed by the GcvR protein. The gcvB-encoded RNAs are required for repression of the Y. pestis dppA gene, encoding the periplasmic-binding protein component of the dipeptide transport system, showing that the GcvB RNAs have regulatory activity. A deletion of the gcvB gene from the Y. pestis KIM6 chromosome results in a decrease in the generation time of the organism as well as a change in colony morphology. CONCLUSION: The results of this study indicate that the Y. pestis gcvB gene encodes two small non-coding regulatory RNAs that repress dppA expression. A gcvB deletion is pleiotropic, suggesting that the sRNAs are likely involved in controlling genes in addition to dppA

    Many Many Leagues at Sea

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    At eve I pace the whiten\u27d sandsI wipe my hair with nervous handsSo thick with dew the shining bands,I sigh I moan oh wearilyFor many, many leagues of seaNow lie between my love and me!For many many leagues of seaNow lie between my love and me. His lips rain\u27d kisses on my hair,He left me standing tumbling there;He said in words, so soft so fair, I will come back, come back to theeThough many, many leagues of seaMay lie between my love and me!Though many, many leagues of seaMay lie between my love and me. Oh say not that I wait in vain!That others watch\u27d with throbbing brainFor truant ones who never came,So false to me, he could bot beThough many, many leagues of seaDo lie between my love and me!Though many, many leagues of seaDo lie between my love and me

    The Ursinus Weekly, October 3, 1949

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    First epistle to the freshmen • Fords to be rivals in home grid clash • Hockey drills start; Frick leads squad • Harriers condition for championships • Bruin eleven yields 21-0 as Drexel breaks streak • Greek prof begins seventeenth season as soccer mentor • Interdorm program set; includes tennis, football • Bears elect leader for grid campaign • Bakermen prepare for season opener • From the sidelines • Kunz, Nicholls go continental • Ursinus star shines in summer theater • Editorial: Senior to frosh • Six assume posts on Ursinus faculty • Forums to include verse and opinions on Arctic, Far East • Teachers j.g. begin trial flights soon • Y to present plans at rally Wednesday • Greenies view Ursinus under bands and bangs • School registers 974 as enrollment drops • WSGA begins duties as committees plan future coed events • Bruin brainmen hit dean\u27s squad 79-29 after 16-week fray • New prexy outlines semester schedule for musical groups • Campus store introduces new hours, coffee machine • President entertains at banquet • Juniors set freshman breakfasthttps://digitalcommons.ursinus.edu/weekly/1572/thumbnail.jp

    Roughness of Interfacial Crack Front: Correlated Percolation in the Damage Zone

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    We show that the roughness exponent zeta of an in-plane crack front slowly propagating along a heterogeneous interface embeded in a elastic body, is in full agreement with a correlated percolation problem in a linear gradient. We obtain zeta=nu/(1+nu) where nu is the correlation length critical exponent. We develop an elastic brittle model based on both the 3D Green function in an elastic half-space and a discrete interface of brittle fibers and find numerically that nu=1.5, We conjecture it to be 3/2. This yields zeta=3/5. We also obtain by direct numerical simulations zeta=0.6 in excellent agreement with our prediction. This modelling is for the first time in close agreement with experimental observations.Comment: 4 pages RevTeX

    Spitzer 24 micron Survey of Debris Disks in the Pleiades

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    We performed a 24 micron 2 Deg X 1 Deg survey of the Pleiades cluster, using the MIPS instrument on Spitzer. Fifty four members ranging in spectral type from B8 to K6 show 24 micron fluxes consistent with bare photospheres. All Be stars show excesses attributed to free-free emission in their gaseous envelopes. Five early-type stars and four solar-type stars show excesses indicative of debris disks. We find a debris disk fraction of 25 % for B-A members and 10 % for F-K3 ones. These fractions appear intermediate between those for younger clusters and for the older field stars. They indicate a decay with age of the frequency of the dust-production events inside the planetary zone, with similar time scales for solar-mass stars as have been found previously for A-stars.Comment: accepted to Ap

    The Ursinus Weekly, May 23, 1949

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    Variety of events await returning alumni June 4 • Speakers\u27 lives promise valuable commencement • Jentsch takes vote of future seniors in class elections • Mazurkiewicz gets \u27Lantern\u27 editorship • Ursinus to award honorary degrees in annual ceremony • Rosicrucians admit four senior girls to full membership • Y plans activities for 1949-50 season at spring retreat • Forum group plans next year\u27s roster; H. Isaacs to speak • Health group plans Pfahler conference • Musicians nominate choices for office • Cub and Key to celebrate tenth anniversary in June • Curtain Club chooses Tom Swan to serve as 1949-1950 president • WSGA to hold banquet • IRC elects officers • Editorial: chapel system • New IRC prexy asks for student interest • Y provides center with changed face by paint, furniture • Bear males take off in revealing take off • Three records fall on Patterson Field in meet with Lehigh • Excellent record shows merits of lady mentor • Rally beats bruins in 5-4 Drexel game • Softballers defeat Albright coeds 12-6 in Reading contest • Ursinus men place fourth in invitation track meet • Bear nine drops pair in final home stand • Local netmen split; secure initial win • Double loss befalls girls\u27 tennis squad • Interdorm softball playoffs to feature Stine and Curtis II • Dragons defeat golfers 5-4 in closing match of season • Tennis competition proves keen as coed jayvees drop 3-2 match • Barnard College considers honor system • Folklore group discusses Pennsylvania German traitshttps://digitalcommons.ursinus.edu/weekly/1619/thumbnail.jp

    The Ursinus Weekly, March 20, 1950

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    Moore Karavan to set mood of April showers • Councils co-operate on detailed inquiry of food situation • Board names Wetzel to top \u27Weekly\u27 post • ICG parley revises state\u27s constitution; makes voting age 18 • Three to undertake department honors in papers, projects • Thespians to offer drama and comedy tomorrow evening • Y chats to feature parleys on purpose of frats, sororities • Engineers improve facilities of WURS to increase range • Freshmen to meet sororities\u27 members • Frederick to direct cast of spring play • Original Ruby musical scores hit • Professors discuss European recovery • Debating fraternity names Edwards as new president • Operetta group prepares for post-Easter production • Bridge enthusiasts laud duplicate tourney variety • A senior confesses famous last words • Bomberger product sees failure hall of science • Fields\u27 Gentlemen Prefer Blondes • Coeds spill Chestnut Hill with good passing attack • Pancoast shoulders diversified tasks; busy with baseball • Chestnut Hill trips belles in badminton • Ursinus belles beat Bryn Mawr College for fifth triumph • Boxers, matmen compete for intramural distinction • Belles down Beaver in tank contest 37-20 • Hoop squad selects all-opponent team; Garnet places two • Bruin players elect mat, court captains to head 1951 teams • Advertiser to meet with business clubhttps://digitalcommons.ursinus.edu/weekly/1588/thumbnail.jp

    The Ursinus Weekly, November 21, 1949

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    Bears trip Crusaders 14-0 to end year • Young passes to victory as student spirit booms • Council to conduct poll on regulations for frosh customs • Local actors prepare for season openers • Y opens toy drive; Plans yule service with singers, actors • WURS plans varied, enlarged setup; to include music, plays, local talent • Students hail team in parade and fete • Scout frat selects Corcoran president • Dr. Cadbury speaks to pre-med group on disease in China • Scholarship winner comes to Ursinus via freighter trip • Spirit reaches peak thanks to efforts of unknown group • The quarter-mark • Thanksgiving • WAA freshmen to arrange sockey-hoccer scrimmage • Football careers end for senior lettermen • F&M takes booters in overtime contest to close campaign • Court squad awaits grid replacements to complete roster • Hockey team beats Chestnut Hill coeds by easy 6-0 count • Five coeds to play final hockey game for Ursinus teams • Soccer team loses quartet of seniors with end of season • Ruby photography proceeds as students await proofshttps://digitalcommons.ursinus.edu/weekly/1578/thumbnail.jp
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