Groundwater pollution impact on the rural areas

This paper presents the impact of groundwater pollution on the land around irregular deposits on bordering rural communities. Rural area has the ability to preserve and restore the natural environment due to reduced anthropogenic pressure, associated with the type of economic exploitation and general development level of productive forces. Environmental quality of rural life has important antistress effects and therefore it is considered a heritage of humanity and should be kept. The paper is particularly important because we have taken into account that aquifer is an important source of water. Pollution is a serious problem affecting the environment and human health, in this case we want to present the study on pollution spreading. Historical pollution site has not been seen to be dangerous, till now. The purpose of this paper is to highlight the influence of pollution on rural areas in the neighborhood of inappropriate landfills and dumps storing waste or byproducts from various industries. In this paper we show the evolution of the pollutant plume from the landfill Şag-Parţa and a slag and ash dump Utvin, Timiş county. Both deposits are located near the town of Timişoara. The models presented in this paper were performed using MODFLOW software

Finasteride as a model for personalized medicine

The side effects of Finasteride are currently a subject of controversy. Some studies report minor or acceptable adverse effects, which decrease after a variable period of time so that they do not necessitate terminating Finasteride administration. However, several clinical and neuro-endocrine studies show that some adverse effects persist indefinitely in the form of post-Finasteride syndrome, even after the drug cessation. This paper presents a possible explanation for these inconsistent findings. First, the study design of either informing or not informing patients prior therapy about possible adverse effects can influence the incidence and magnitude of reported adverse effects. Second, structural and information dichotomies of the brain generate four distinct neuronal networks, which are activated through specific cerebral neuromodulators and that are able to support four distinct minds within an individual body. As a conclusion, the “mind psychophysiology” and the corresponding mental impairments differ across individuals, such that not only the prediction of adverse effects should be addressed from a more individualized medical perspective, but also the therapeutic strategies could be tailored to the four distinct mental profiles described. It is a personalized approach that would be applicable to several interrelated domains of neuroscience, like psychology, psychiatry and sexuality. Finally, this perspective may represent a starting point for a more individualized understanding of mental events, perhaps even a step forward in the understanding of the mind-body problem

Androgenic alopecia; the risk–benefit ratio of Finasteride

Finasteride is currently approved and largely used as a therapeutic option for androgenetic alopecia. Apparently a safe drug and effective at the onset of its application, several concerns have since appeared over the years regarding the frequency and magnitude of finasteride adverse effects, which in some cases appear irreversible even after drug termination. This paper discusses the use of finasteride for androgenic alopecia from two distinct perspectives. On the one hand, androgenic alopecia is a condition that especially affects a person’s self-image and esteem, aspects that are subjectively-constructed and thus relative and changeable. On the other hand, this condition involves a multifactorial etiology, with androgens being only partly responsible. Because androgens have important and unique physiological roles within the body, any procedure that results in androgenic suppression should be advised with caution. Furthermore, adverse effects induced by finasteride are neither fully documented nor easily treated. Finally, as alternative therapeutic approaches (such as topical finasteride) become available, the oral administration of finasteride for androgenic alopecia should, in our opinion, be reevaluated. Due to such concerns, a detailed and informed discussion should take place with patients considering therapy with finasteride for androgenic alopecia

Therapeutic Considerations Related to Finasteride Administration in Male Androgenic Alopecia and Benign Prostatic Hyperplasia

Finasteride has been used extensively until now as a relative efficient therapeutic option for male androgenic alopecia and benign prostatic hyperplasia. Unfortunately, over time several concerns appeared regarding the frequency and magnitude of adverse effects, which in some cases have been even irreversible. Herein we review the recent literature on this topic, trying to clarify the current safety profile of Finasteride for these two therapeutic indications. We concluded that Finasteride could be retained as a therapeutic approach for male androgenic alopecia, based on two important reasons. First, a synergistic action between a partial inhibitor of 5α-reductase (Finasteride) and another compound (like Minoxidil) are preferable to a complete suppression of 5α-reductase (see Dutasteride), in order to preserve the important physiological roles of dihydrotestosterone. Second, Finasteride side effects can currently be addressed in part prior to the onset of the therapy, by using information about the patient such as hand preference and sexual orientation to predict the risk of adverse effects

The postfinasteride syndrome; an overview

As a 5-α reductase inhibitor, Finasteride has proven effective in ameliorating two conditions documented to be androgen dependent, namely male androgenic alopecia and benign prostatic hyperplasia. Therapeutic results are maintained as long as the drug is administered, with treatment cessation generally leading to the return of symptomatology for each condition. In addition, during the therapeutic phase, several adverse effects have been reported, some of which persist long or indefinitely after treatment cessation, known as “post-finasteride syndrome.” Herein we present and discuss the most common finasteride side effects, along with a psycho-neuroendocrine rationale that could explain the persistence of many adverse effects after treatment cessation. Moreover, we argue that finasteride adverse effects occurring during finasteride administration should be delineated from postfinasteride side effects (encountered after treatment cessation), suggesting the need to be addressed separately within a therapeutic perspective. Until a tailored therapeutic approach of postfinasteride syndrome becomes available, we have noted that hand preference and sexual orientation seem to be useful as possible predicting factors for finasteride side effects and postfinasteride syndrome. Finally, even though finasteride administration is considered relatively safe, literature data urges prudence. Specifically, recent studies report that some subjects receiving finasteride develop severe depressive episodes including suicidal thoughts, in part due to persistent sexual side effects

Groundwater pollution impact on the rural areas

This paper presents the impact of groundwater pollution on the land around irregular deposits on bordering rural communities. Rural area has the ability to preserve and restore the natural environment due to reduced anthropogenic pressure, associated with the type of economic exploitation and general development level of productive forces. Environmental quality of rural life has important antistress effects and therefore it is considered a heritage of humanity and should be kept. The paper is particularly important because we have taken into account that aquifer is an important source of water. Pollution is a serious problem affecting the environment and human health, in this case we want to present the study on pollution spreading. Historical pollution site has not been seen to be dangerous, till now. The purpose of this paper is to highlight the influence of pollution on rural areas in the neighborhood of inappropriate landfills and dumps storing waste or byproducts from various industries. In this paper we show the evolution of the pollutant plume from the landfill Şag-Parţa and a slag and ash dump Utvin, Timiş county. Both deposits are located near the town of Timişoara. The models presented in this paper were performed using MODFLOW software