Creatine consumption and liver disease manifestations in individuals aged 12 years and over

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Guanidinoacetate–creatine in secondary progressive multiple sclerosis: a case report

Acute secondary progressive multiple sclerosis (SPMS) is characterized by escalating neurological disability, with limited disease-modifying therapeutic options. A 48-year-old woman with acute SPMS being treated with interferon beta-1a and oral corticosteroids presented as a clinical out- patient with no disease-modifying effects after treatment. A decision was made to treat her with a combination of guanidinoacetate and creatine for 21 days. She had made clinical progress at follow-up, with the intensity of fatigue dropping from severe to mild. Magnetic resonance spec- troscopy revealed increased brain choline, creatine, N-acetylaspartate, and glutathione. Patients with SPMS may benefit from guanidinoacetate–creatine treatment in terms of patient- and clinician-reported outcomes; this requires additional study.publishedVersio

Effects of six-month creatine supplementation on patient- and clinician-reported outcomes, and tissue creatine levels in patients with post-COVID-19 fatigue syndrome

Dietary creatine has been recently put forward as a possible intervention strategy to reduce post-COVID-19 fatigue syndrome yet no clinical study so far evaluated its efficacy and safety for this perplexing condition. In this parallel-group, randomized placebo-controlled double-blind trial, we analyzed the effects of 6-month creatine supplementation (4 g of creatine monohydrate per day) on various patient- and clinician-reported outcomes, and tissue creatine levels in 12 patients with post-COVID-19 fatigue syndrome. Creatine intake induced a significant increase in tissue creatine levels in vastus medialis muscle and right parietal white matter compared to the baseline values at both 3-month and 6-month follow-ups (p < .05). Two-way analysis of variance with repeated measures revealed a significant difference (treatment vs. time interaction) between interventions in tissue creatine levels (p < .05), with the creatine group was superior to placebo to augment creatine levels at vastus medialis muscle, left frontal white matter, and right parietal white matter. Creatine supplementation induced a significant reduction in general fatigue after 3 months of intake compared to baseline values (p = .04), and significantly improved scores for several post-COVID-19 fatigue syndrome-related symptoms (e.g., ageusia, breathing difficulties, body aches, headache, and difficulties concentrating) at 6-month follow-up (p < .05). Taking creatine for 6 months appears to improve tissue bioenergetics and attenuate clinical features of post-COVID-19 fatigue syndrome; additional studies are warranted to confirm our findings in various post-COVID-19 cohorts.publishedVersio

Effects of acute b-alanine supplemetation on countermovement jump performance after a 4x400 m fatigue protocol: a randomized, double-blind, placebo-controlled trial

This study aimed to examine the effect of acute beta-alanine (β-alanine) supplementation on jump performance after a strenuous fatigue protocol. Twelve healthy young men (age 21.4±0.5 years, body height 180.2±5.8 cm, body mass 76.6±9.2 kg) volunteered to participate in this randomized, double-blind, placebo-controlled trial. The experimental group ingested 3.2 g of β-alanine (separated into two 1.6 g dosages) mixed with 23 g of glucose, whereas the placebo group ingested two dosages containing 23 g of glucose. Following the supplementation intake, participants completed a jump protocol involving countermovement jump (CMJ) and four consecutive countermovement jumps (CMJ-4). Subsequently, a 4x400 m running fatigue protocol was carried out to produce fatigue. After the fatigue protocol, the same jumping tests were repeated, CMJ and CMJ-4, to evaluate the loss in jump height. The Mann-Whitney U test was used to analyze differences between the groups, whereas Wilcoxon signed-rank test was conducted to analyze differences within the groups with statistical significance set at p<.05. After β-alanine supplementation, no significant decrease in jump height was found in the experimental group in none of the tests after the fatigue protocol. Conversely, a significant decrease was noticed in the placebo group in CMJ but not in the CMJ-4 test. In conclusion, an acute β-alanine supplementation could attenuate jump height loss after the fatigue protocol. Therefore, athletes and coaches should consider acute β-alanine supplementation to attenuate sports performance decrease after high-intensity exercises in which muscle acidosis is highly increased

Rapid weight loss habits before a competition in sambo athletes

Background: Like other combat sports, sambo has competition rules that divide athletes into categories based on gender, age and weight. Athletes in combat sports often resort to rapid weight loss (RWL) methods to be more competitive in lower weight categories and gain an advantage against lighter, smaller and weaker competitors. The aim of this study was to examine the methodology implemented by two different sambo age categories, junior and senior athletes, in order to attain RWL. Methods: The sample consisted of 103 male sambo elite athletes (seniors/juniors: age 28.5 ± 4.3/18.9 ± 0.8; height (m): 1.7 ± 0.1/1.8 ± 0.1; weight (kg): 76.3 ± 17.8/74.4 ± 16.3; BMI (kg/m2): 25.0 ± 3.8/23.7 ± 3.9) who completed a survey on RWL. Results: Athletes reported losing a mean of 5 kg starting approximately 12 days before a competition. The most common methodology reported by senior and junior sambo athletes was gradually increasing dieting, followed by sauna and plastic suit training. Less common methods adopted were laxatives, diuretics, the use of diet pills and vomiting. There were significant group differences for sauna and diet pill ingestion. Coaches and parents are influential people in the lives of athletes concerning the weight loss strategy to be adopted. Conclusions: This study’s results unequivocally confirm the prevalent practice of RWL in both senior and junior sambo athletes. Although athletes prevalently chose “less harmful” methods, there is a need to inform parents and coaches of the risks and benefits of RWL

Odnos između sastava tijela i HRQOL kod djece u osnovnoj školi

The dramatic rise in the prevalence of obesity in developed and in developing countries has become a major health care concern. There is an increasing recognition of the relationship between health-related quality of life (HRQOL) and obesity in the pediatric population. Subjective experience of one’s own health, and how children see their own lives is also very important. Children with an increased amount of body fat have a negative perception of the HRQOL, unlike those who have a normal amount of body fat. A total of 181 children participated in this study (mean age 7.71 ±0.29 years, 88 girls). For the assessment of the body composition the InBody 230 device was used, while for the assessment of HRQOL the proxy version of KIDSCREEN-27 questionnaire was used. The aim of the study was to explore the relationship between the body composition and the HRQOL in children of primary school age. The analysis of the results showed that the BMI is in significant negative correlation with the two dimensions of HRQOL in boys (Psychological Well-being and School), while in girls there is no statistically significant relationship. The correlation between the Percentage of Body Fat (PBF) and HRQOL is significant and negative in boys in 4 dimensions (Physical Well-being, Psychological Well-being, Social Support & Peers, School), while in girls it is negative and significant only in one dimension (Physical Well-being). The results indicate that there are changes in the body composition of children, such as the increased BMI and BFP, reduced HRQOL, i.e. obesity is in inverse relationship to HRQOL.Dinamičan porast prevalencije pretilosti u razvijenim zemljama i onima u razvoju postao je glavna briga zdravstvene zaštite. Postoji veća značajnost odnosa između kvalitete života u vezi sa zdravljem (HRQOL) i pretilosti pedijatrijske populacije. Subjektivan dojam i dojam vlastitog zdravlja i dječjeg viđenja vlastitog života također su vrlo važni. Djeca s povećanom količinom masne mase imaju negativnu percepciju o HRQOL za razliku od djece koja imaju normalnu količinu tjelesne masti. U ovom istraživanju sudjelovalo je 181 dijete (prosječne dobi 7.71 (0.29) godina, 88 djevojčica). Za procjenu sastava tijela koristio se InBody 230 uređaj, a za procjenu HRQOL koristila se proxy verzija KIDSCREEN-27 upitnika. Cilj studije bio je istražiti odnose između sastava tijela i HRQOL na djecu u osnovnoškolskoj dobi. Analiza rezultata je pokazala kako je ITM u značajnoj negativnoj korelaciji s dvije dimenzije HRQOL kod dječaka (psihološka dobrobit i škola), a da kod djevojčica ne postoji statistička veza. Korelacije između postotaka masnog tkiva (PMT) i HRQOL značajne su i negativne kod dječaka u 4 dimenzije (tjelesno blagostanje, psihičko blagostanje, socijalna podrška i vršnjaci, škola), a kod djevojčica je negativan i značajan samo u jednoj dimenziji (tjelesno blagostanje). Rezultati pokazuju da postoje promjene u sastavu tijela djece, kao što su ITM i PMT smanjene HRQOL, odnosno da je pretilost u obrnuto proporcionalnom inverznom odnosu s HRQOL-om

Cardiorespiratory fitness in volleyball athletes following a covid-19 infection: A cross-sectional study

Athletes’ lifestyles have been dramatically affected by the coronavirus disease 2019 (COVID-19) pandemic. Since COVID-19 primarily affects the respiratory system and to a lesser degree the cardiovascular system, the goal of this study was to examine the effects of COVID-19-caused detraining on cardiorespiratory fitness (CRF) of recently recovered volleyball athletes. Sixteen experienced volleyball athletes (age 24 ± 4.5 years) who were recently diagnosed and recovered from a COVID-19 infection volunteered to participate in this study and were tested for CRF and spirometry. Given that participants had only mild symptoms of infection, the primary focus of this study was on the effects of detraining on CRF. On average, the time to exhaustion was 9.4 ± 1.4 min. VE, VCO2, RER and oxygen pulse increased, heart rate exceeded 90% of predicted values, and peak VO2 values were typical for this level of athlete (44.1 ± 3.4 mL/kg). Pulmonary function reflected in FVC, FEV1/FVC and MVV values were well above 80% of predicted values for each of the participants while electrocardiography revealed no ischemia, arrythmias or conduction and repolarization abnormalities were found in the tested subjects. Conclusions: participants experienced typical consequences of detraining. Due to a lack of CRF data prior to COVID-19 infection, we were unable to estimate the magnitude detraining had on CRF. Complete CRF assessment after COVID-19 infection in athletes can be useful for screening of residual myocardial and/or respiratory system damage for safe return-to-play decisions

The effects of rapid weight loss on skeletal muscle in judo athletes

Objective: To observe the effect of rapid weight loss (RWL) methods over 3 days on muscle damage in judokas. Methods: Eighteen judokas participated in this crossover study, meaning that judo athletes were subjected to exercise-only phase (4 days) and RWL phase (3 days). Subjects were tested for myoglobin, creatine kinase, aldolase, hemoglobin, and hematocrit values on seven consecutive days. These biomarkers served as indicators of acute muscle damage. Results: During the exercise-only phase, no significant changes were observed. Myoglobin (Mb) (p &lt; 0.001), creatine kinase (CK) (p &lt; 0.001) and aldolase (ALD) (p &lt; 0.001) significantly increased only during the RWL phase, as well as hemoglobin (Hb) (p &lt; 0.001) and hematocrit (Hct) (p &lt; 0.005) values. It was detected that peak values for muscle damage biomarkers were reached on the sixth day, while Hct and Hb values were the highest on the seventh day of the study. Conclusion: Our study showed significant muscle damage induced by RWL. The prevalence of RWL use by judokas is high but firm scientific evidence is lacking in the evaluation of the current practice of it. Therefore, further knowledge must be gained to evaluate the effectiveness of RWL on performance and its impact on judokas' wellbeing

Patterns of rapid weight loss in elite sambo athletes

Background: Rapid weight loss (RWL) is commonly practiced in combat sports. Both magnitude and methods used to induce RWL are largely similar among combat sports, but currently, there is no data on RWL methodology used by sambo athletes. Therefore, the aim of this study was to determine RWL procedures sambo athletes apply to lose weight rapidly. Methods: The sample consisted of 199 participants, of which 132 males and 67 females who participated in the World Sambo Championship 2020 held in Novi Sad, Serbia. Each participant received RWL questionnaire that was available in multiple languages, and every participant was instructed how to fill it out. Results: Almost 87% of sambo participants declared to have intentionally cut their weight prior to the competition, whereby 5.27 kg (SD: ±7.57) was lost. Gradual dieting, sauna use and skipping meals were the most dominant methods used to reduce weight prior to competition while more extreme methods of RWL such as the use of laxatives, diuretics, diet pills and vomiting were also implemented but by much smaller fragment of the participants involved. Conclusions: Findings from our study largely match with previously conducted RWL studies in terms of prevalence, magnitude and methods used by combat sport athletes, especially in judo and wrestling. Knowing the hazardous consequences of RWL, alternative methods of sustainable weight loss should be considered