7 research outputs found
Experimental Development of a Constitutive Model for High-Speed Impact Containment Fabrics
- Publication venue
- 'American Society of Civil Engineers (ASCE)'
- Publication date
- Field of study
A study on the influence of a surface-contacting spinning strand on yarn appearance during sirofil spinning
- Author
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
Containment of high-speed rotating disk fragments
- Author
- Publication venue
- 'Zhejiang University Press'
- Publication date
- Field of study
Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion
- Author
- A Aggarwal
- A Alimonti
- A Chicas
- A Kukita
- A Subramanian
- Ainara Egia
- AJ Stephenson
- AK Bosserhoff
- AK Bosserhoff
- Andrea Lunardi
- AT Kwon
- B Ren
- Brett Carver
- BS Carver
- BS Taylor
- C Robbe
- Carlos Cordon-Cardo
- Caterina Nardella
- CS Grasso
- David R Shaffer
- DE Root
- DH Wang
- DK Vanaja
- E LaTulippe
- Enrique Gonzalez-Billalabeitia
- G Sun
- Guocan Wang
- H Müller
- H Qu
- H Sun
- H Wang
- HA Drabkin
- J Lapointe
- J Qian
- J Schmidt
- J Stahlecker
- JA Costoya
- JC King
- JH Luo
- Jiangwen Zhang
- JM Davies
- JM Sterner
- JP Clark
- KA Dudek
- Kaitlyn A Webster
- L Jiang
- L Pasqualucci
- L Poliseno
- L Poliseno
- LC Trotman
- LC Vredeveld
- M Guba
- MK Thomsen
- MS Arredouani
- NM Navone
- P De Santa Barbara
- P Liu
- Pier Paolo Pandolfi
- PK Majumder
- PS Pendergrast
- Riccardo Taulli
- S Murakami
- S Tynan
- SA Tomlins
- SA Tomlins
- SA Tomlins
- Sabina Signoretti
- SJ Ho Sui
- SJ Ho Sui
- T Maeda
- T Maeda
- TA Wallace
- Ugo Ala
- VK Mootha
- W Cheung
- W Kang
- W Kang
- WF Xie
- William L Gerald
- Winston Patrick Kuo
- WP Tsang
- X Cai
- X Chen
- X He
- X Wu
- Xue-Song Liu
- Yvonne Tay
- Z Chen
- Z Chen
- Z Ding
- Z Zhang
- ZH Zhao
- Zhenbang Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
Zbtb7a has previously been described as a powerful proto-oncogene. Here we unexpectedly demonstrate that Zbtb7a has a critical oncosuppressive role in the prostate. Prostate-specific inactivation of Zbtb7a leads to a marked acceleration of Pten loss-driven prostate tumorigenesis through bypass of Pten loss-induced cellular senescence (PICS). We show that ZBTB7A physically interacts with SOX9 and functionally antagonizes its transcriptional activity on key target genes such as MIA, which is involved in tumor cell invasion, and H19, a long noncoding RNA precursor for an RB-targeting microRNA. Inactivation of Zbtb7a in vivo leads to Rb downregulation, PICS bypass and invasive prostate cancer. Notably, we found that ZBTB7A is genetically lost, as well as downregulated at both the mRNA and protein levels, in a subset of human advanced prostate cancers. Thus, we identify ZBTB7A as a context-dependent cancer gene that can act as an oncogene in some contexts but also has oncosuppressive-like activity in PTEN-null tumors. © 2013 Nature America, Inc. All rights reserved
Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion
- Author
- A Aggarwal
- A Alimonti
- A Chicas
- A Kukita
- A Subramanian
- Ainara Egia
- AJ Stephenson
- AK Bosserhoff
- AK Bosserhoff
- Andrea Lunardi
- AT Kwon
- B Ren
- Brett Carver
- BS Carver
- BS Taylor
- C Robbe
- Carlos Cordon-Cardo
- Caterina Nardella
- CS Grasso
- David R Shaffer
- DE Root
- DH Wang
- DK Vanaja
- E LaTulippe
- Enrique Gonzalez-Billalabeitia
- G Sun
- Guocan Wang
- H Müller
- H Qu
- H Sun
- H Wang
- HA Drabkin
- J Lapointe
- J Qian
- J Schmidt
- J Stahlecker
- JA Costoya
- JC King
- JH Luo
- Jiangwen Zhang
- JM Davies
- JM Sterner
- JP Clark
- KA Dudek
- Kaitlyn A Webster
- L Jiang
- L Pasqualucci
- L Poliseno
- L Poliseno
- LC Trotman
- LC Vredeveld
- M Guba
- MK Thomsen
- MS Arredouani
- NM Navone
- P De Santa Barbara
- P Liu
- Pier Paolo Pandolfi
- PK Majumder
- PS Pendergrast
- Riccardo Taulli
- S Murakami
- S Tynan
- SA Tomlins
- SA Tomlins
- SA Tomlins
- Sabina Signoretti
- SJ Ho Sui
- SJ Ho Sui
- T Maeda
- T Maeda
- TA Wallace
- Ugo Ala
- VK Mootha
- W Cheung
- W Kang
- W Kang
- WF Xie
- William L Gerald
- Winston Patrick Kuo
- WP Tsang
- X Cai
- X Chen
- X He
- X Wu
- Xue-Song Liu
- Yvonne Tay
- Z Chen
- Z Chen
- Z Ding
- Z Zhang
- ZH Zhao
- Zhenbang Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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- 'Springer Science and Business Media LLC'
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- 01/01/1965
- Field of study
The Sixth Problem of Generalized Algebraic Regression
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- A Bjerhammar
- A Cayley
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- W Gander
- W Gautschi
- W Mueller
- W Oktaba
- W Sun
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- X Chen
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