1,039 research outputs found
Employee Retention in Insurance Claim Adjusting: A Growing Problem with Few Solutions
This paper defines and documents the growing problem of employee turnover and the failure by insurance and by claim adjusting companies to increase employee retention. According to industry sources, insurance is in the industry with the highest rate of employee turnover. This comes at a significant financial loss and what is called “contagious dissatisfaction,” resulting in a toxic work culture. Further, the growing problem of employee turnover in insurance claim adjusting comes at a time when nearly half of employee talent recruiters report that it is getting harder to find skilled candidates in a number of functional areas, including claims.
The problem can be traced to promises upon hire which do not match the reality of the working position, overworking claim adjusters in general, hiring claim adjusters as managers rather than managers of people who know claims, as well as a failure to mitigate the “aggregate of incoming,” which is defined in this paper as the total amount of daily emails, letters, attachments, calls, and all other claim-related items adjusters receive. If companies address these areas and work with adjusters to manage a reasonable claim pending, they will experience less turnover, higher employee retention, decrease financial losses, and improve their work culture
The first super-Earth Detection from the High Cadence and High Radial Velocity Precision Dharma Planet Survey
The Dharma Planet Survey (DPS) aims to monitor about 150 nearby very bright
FGKM dwarfs (within 50 pc) during 20162020 for low-mass planet detection and
characterization using the TOU very high resolution optical spectrograph
(R100,000, 380-900nm). TOU was initially mounted to the 2-m Automatic
Spectroscopic Telescope at Fairborn Observatory in 2013-2015 to conduct a pilot
survey, then moved to the dedicated 50-inch automatic telescope on Mt. Lemmon
in 2016 to launch the survey. Here we report the first planet detection from
DPS, a super-Earth candidate orbiting a bright K dwarf star, HD 26965. It is
the second brightest star ( mag) on the sky with a super-Earth
candidate. The planet candidate has a mass of 8.47,
period of d, and eccentricity of . This RV
signal was independently detected by Diaz et al. (2018), but they could not
confirm if the signal is from a planet or from stellar activity. The orbital
period of the planet is close to the rotation period of the star (3944.5 d)
measured from stellar activity indicators. Our high precision photometric
campaign and line bisector analysis of this star do not find any significant
variations at the orbital period. Stellar RV jitters modeled from star spots
and convection inhibition are also not strong enough to explain the RV signal
detected. After further comparing RV data from the star's active magnetic phase
and quiet magnetic phase, we conclude that the RV signal is due to
planetary-reflex motion and not stellar activity.Comment: 13 pages, 17 figures, Accepted for publication in MNRA
Stability testing of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine: a translational study in UK vaccination centres
Objective - The roll-out of the Pfizer-BioNTech BNT162b2 COVID-19 vaccine has brought many logistical challenges, such as the absence of comprehensive stability data leading to strict handling instructions during dilution and administration. Accidental mishandling therefore presents challenging clinical dilemmas, which often led vaccine providers to err on the side of caution and discard mishandled vials rather than risk administering ineffective vaccine. This study aims to answer key questions about the vaccine’s stability to allow for a more informed decision-making process should a non-conformity occur.
Methods - Residual vaccine in freshly used, but appropriately stored vials collected from vaccination centres in Brighton, UK, were tested after exposure to various handling conditions and analysed by dynamic light scattering to determine the size of the lipid-mRNA nanoparticles, and gel electrophoresis to visualise the mRNA integrity and separation from the lipid formulation.
Results - Knocking or dropping vaccine samples from small heights resulted in lowest levels of instability, indicating low risk of compromising clinical efficacy. However, repeated drawing and injecting through 23 G needles at high speed and, more significantly, shaking and vortexing led to progressive increase in the size and polydispersity index of the lipid-mRNA nanoparticles, coupled with or caused by up to ~50% release of mRNA from the lipid formulation. This is thought to impact the vaccine’s efficacy due to lack of free mRNA protection and cellular internalisation.
Conclusions - These results reiterate the importance of adhering to the manufacturer’s instructions on handling, especially with regard to shaking and exposing the vaccine to excessive vibration
The first super-Earth detection from the high cadence and high radial velocity precision Dharma Planet Survey
The Dharma Planet Survey (DPS) aims to monitor about 150 nearby very bright FGKM dwarfs (within 50 pc) during 2016–2020 for low-mass planet detection and characterization using the TOU very high resolution optical spectrograph (R≈100000, 380–900 nm). TOU was initially mounted to the 2-m Automatic Spectroscopic Telescope at Fairborn Observatory in 2013–2015 to conduct a pilot survey, then moved to the dedicated 50-inch automatic telescope on Mt. Lemmon in 2016 to launch the survey. Here, we report the first planet detection from DPS, a super-Earth candidate orbiting a bright K dwarf star, HD 26965. It is the second brightest star (V = 4.4 mag) on the sky with a super-Earth candidate. The planet candidate has a mass of 8.47 ± 0.47MEarth, period of 42.38 ± 0.01 d, and eccentricity of 0.04+0.05−0.03. This radial velocity (RV) signal was independently detected by Díaz et al., but they could not confirm if the signal is from a planet or stellar activity. The orbital period of the planet is close to the rotation period of the star (39–44.5 d) measured from stellar activity indicators. Our high precision photometric campaign and line bisector analysis of this star do not find any significant variations at the orbital period. Stellar RV jitters modelled from star-spots and convection inhibition are also not strong enough to explain the RV signal detected. After further comparing RV data from the star’s active magnetic phase and quiet magnetic phase, we conclude that the RV signal is due to planetary-reflex motion and not stellar activity
Tumor Progression Locus 2 (Tpl2) Deficiency Does Not Protect against Obesity-Induced Metabolic Disease
Obesity is associated with a state of chronic low grade inflammation that plays an important role in the development of insulin resistance. Tumor progression locus 2 (Tpl2) is a serine/threonine mitogen activated protein kinase kinase kinase (MAP3K) involved in regulating responses to specific inflammatory stimuli. Here we have used mice lacking Tpl2 to examine its role in obesity-associated insulin resistance. Wild type (wt) and tpl2−/− mice accumulated comparable amounts of fat and lean mass when fed either a standard chow diet or two different high fat (HF) diets containing either 42% or 59% of energy content derived from fat. No differences in glucose tolerance were observed between wt and tpl2−/− mice on any of these diets. Insulin tolerance was similar on both standard chow and 42% HF diets, but was slightly impaired in tpl2−/− mice fed the 59% HFD. While gene expression markers of macrophage recruitment and inflammation were increased in the white adipose tissue of HF fed mice compared with standard chow fed mice, no differences were observed between wt and tpl2−/− mice. Finally, a HF diet did not increase Tpl2 expression nor did it activate Extracellular Signal-Regulated Kinase 1/2 (ERK1/2), the MAPK downstream of Tpl2. These findings argue that Tpl2 does not play a non-redundant role in obesity-associated metabolic dysfunction
Lived Experience-Led Research Agenda to Address Early Death in People With a Diagnosis of a Serious Mental Illness: A Consensus Statement
Importance People with serious mental illness (SMI), defined as a diagnosis of schizophrenia spectrum disorder, bipolar disorder, or disabling major depressive disorder) die approximately 10 to 25 years earlier than the general population.
Objective To develop the first-ever lived experience–led research agenda to address early mortality in people with SMI.
Evidence Review A virtual 2-day roundtable comprising 40 individuals convened on May 24 and May 26, 2022, and used a virtual Delphi method to arrive at expert group consensus. Participants responded to 6 rounds of virtual Delphi discussion via email that prioritized research topics and agreement on recommendations. The roundtable was composed of individuals with lived experience of mental health and/or substance misuse, peer support specialists, recovery coaches, parents and caregivers of people with SMI, researchers and clinician-scientists with and without lived experience, policy makers, and patient-led organizations. Twenty-two of 28 (78.6%) of the authors who provided data represented people with lived experiences. Roundtable members were selected by reviewing the peer-reviewed and gray literature on early mortality and SMI, direct email, and snowball sampling.
Findings The following recommendations are presented in order of priority as identified by the roundtable participants: (1) improve the empirical understanding of the direct and indirect social and biological contributions of trauma on morbidity and early mortality; (2) advance the role of family, extended families, and informal supporters; (3) recognize the importance of co-occurring disorders and early mortality; (4) redefine clinical education to reduce stigma and support clinicians through technological advancements to improve diagnostic accuracy; (5) examine outcomes meaningful to people with an SMI diagnosis, such as loneliness and sense of belonging, and stigma and their complex relationship with early mortality; (6) advance the science of pharmaceuticals, drug discovery, and choice in medication use; (7) use precision medicine to inform treatment; and (8) redefine the terms system literacy and health literacy.
Conclusions and Relevance The recommendations of this roundtable are a starting point for changing practice and highlighting lived experience–led research priorities as an option to move the field forward.publishedVersio
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