Galactic cosmic rays on extrasolar Earth-like planets: II. Atmospheric implications

(abridged abstract) Theoretical arguments indicate that close-in terrestial exoplanets may have weak magnetic fields. As described in the companion article (Paper I), a weak magnetic field results in a high flux of galactic cosmic rays to the top of the planetary atmosphere. We investigate effects that may result from a high flux of galactic cosmic rays both throughout the atmosphere and at the planetary surface. Using an air shower approach, we calculate how the atmospheric chemistry and temperature change under the influence of galactic cosmic rays for Earth-like (N_2-O_2 dominated) atmospheres. We evaluate the production and destruction rate of atmospheric biosignature molecules. We derive planetary emission and transmission spectra to study the influence of galactic cosmic rays on biosignature detectability. We then calculate the resulting surface UV flux, the surface particle flux, and the associated equivalent biological dose rates. We find that up to 20% of stratospheric ozone is destroyed by cosmic-ray protons. The reduction of the planetary ozone layer leads to an increase in the weighted surface UV flux by two orders of magnitude under stellar UV flare conditions. The resulting biological effective dose rate is, however, too low to strongly affect surface life. We also examine the surface particle flux: For a planet with a terrestrial atmosphere, a reduction of the magnetic shielding efficiency can increase the biological radiation dose rate by a factor of two. For a planet with a weaker atmosphere (with a surface pressure of 97.8 hPa), the planetary magnetic field has a much stronger influence on the biological radiation dose, changing it by up to two orders of magnitude.Comment: 14 pages, 9 figures, published in A&

Galactic cosmic rays on extrasolar Earth-like planets I. Cosmic ray flux

(abridged abstract) Theoretical arguments indicate that close-in terrestial exoplanets may have weak magnetic fields, especially in the case of planets more massive than Earth (super-Earths). Planetary magnetic fields, however, constitute one of the shielding layers that protect the planet against cosmic-ray particles. In particular, a weak magnetic field results in a high flux of Galactic cosmic rays that extends to the top of the planetary atmosphere. We wish to quantify the flux of Galactic cosmic rays to an exoplanetary atmosphere as a function of the particle energy and of the planetary magnetic moment. We numerically analyzed the propagation of Galactic cosmic-ray particles through planetary magnetospheres. We evaluated the efficiency of magnetospheric shielding as a function of the particle energy (in the range 16 MeV $\le$ E $\le$ 524 GeV) and as a function of the planetary magnetic field strength (in the range 0 ${M}_\oplus$ $\le$ {M} $\le$ 10 ${M}_\oplus$). Combined with the flux outside the planetary magnetosphere, this gives the cosmic-ray energy spectrum at the top of the planetary atmosphere as a function of the planetary magnetic moment. We find that the particle flux to the planetary atmosphere can be increased by more than three orders of magnitude in the absence of a protecting magnetic field. For a weakly magnetized planet (${M}=0.05\,{M}_{\oplus}$), only particles with energies below 512 MeV are at least partially shielded. For a planet with a magnetic moment similar to Earth, this limit increases to 32 GeV, whereas for a strongly magnetized planet ($M=10.0\,{M}_{\oplus}$), partial shielding extends up to 200 GeV. We find that magnetic shielding strongly controls the number of cosmic-ray particles reaching the planetary atmosphere. The implications of this increased particle flux are discussed in a companion article.Comment: 10 pages, 9 figures; accepted in A&

Consommation des jeunes et jeunes adultes en fin de semaine : Evolution entre 2011, 2013 et 2015

Parmi les 691 jeunes de 15 à 29 ans qui ont participé au module jeune en 2015, 629 sont sortis au cours des 30 jours précédant la passation de l’enquête. Les réponses données par ces derniers permettent de compléter les résultats déjà obtenus précédemment concernant les consommations des jeunes lors de leur dernière sortie de fin de semaine. De manière générale, il n’existe pas de tendance nette chez les jeunes vers une hausse ou une diminution de la consommation de substances entre 2011 et 2015. L’alcool reste la substance la plus consommée par les jeune

Exogenous schwann cells migrate, remyelinate and promote clinical recovery in experimental auto-immune encephalomyelitis

Schwann cell (SC) transplantation is currently being discussed as a strategy that may promote functional recovery in patients with multiple sclerosis (MS) and other inflammatory demyelinating diseases of the central nervous system (CNS). However this assumes they will not only survive but also remyelinate demyelinated axons in the chronically inflamed CNS. To address this question we investigated the fate of transplanted SCs in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) in the Dark Agouti rat; an animal model that reproduces the complex inflammatory demyelinating immunopathology of MS. We now report that SCs expressing green fluorescent protein (GFP-SCs) allografted after disease onset not only survive but also migrate to remyelinate lesions in the inflamed CNS. GFP-SCs were detected more frequently in the parenchyma after direct injection into the spinal cord, than via intra-thecal delivery into the cerebrospinal fluid. In both cases the transplanted cells intermingled with astrocytes in demyelinated lesions, aligned with axons and by twenty one days post transplantation had formed Pzero protein immunoreactive internodes. Strikingly, GFP-SCs transplantation was associated with marked decrease in clinical disease severity in terms of mortality; all GFP-SCs transplanted animals survived whilst 80% of controls died within 40 days of disease

The murine male reproductive organ at a glance: Three-dimensional insights and virtual histology using label-free light sheet microcopy

Background:The unique anatomy of the male reproductive organ reflects its complex function from sperm maturation to their storage for months until emission. Since light microscopy in two dimensions (2d) cannot sufficiently demonstrate its complex morphology, a comprehensive visualization is required to identify pathologic alterations in its entire anatomical context.Objectives:Aim of this study was to use three-dimensional (3d) light sheet fluorescence microscopy (LSFM) to visualize entire murine testes in 3d, label-free and at subcellular resolution, and to assign local autofluorescence to testicular and deferent structures.Materials and methods:Murine testes were fixed with four different fixatives and subsequently cleared with benzoic acid/benzyl benzoate. Hereafter, complete murine testes were scanned with LSFM with different fluorescence filter sets and subsequently embedded in paraffin for further conventional planar histology.Results:Autofluorescence signals of the murine reproductive organ allowed the unambiguous identification of the testicular anatomy from the seminiferous tubules to the vas deferens with their specific stratification independent of the used fixative. Blood vessels were visualized from the pampiniform plexus to the small capillaries of single tubules. Moreover, due to the specific intrinsic fluorescence properties of the efferent ducts and the epididymis, luminal caliber, the epithelial stratification and retronuclear cytoplasmic inclusions gave a unique insight into the interface of both morphological structures. Subsequent 2d histology confirmed the identified morphological structures.Discussion:LSFM analysis of the murine reproductive organ allows due to its intrinsic fluorescence a simple, label-free 3d assessment of its entire duct morphology, the epithelial composition, and the associated blood supply in its anatomical relation.Conclusion:LSFM provides the technical basis for comprehensive analyses of pathologically altered murine testes in its entirety by depicting specific autofluorescence. Thereby it facilitates mouse studies of testicular disease or their drug-related alterations in more detail potentially for clinical translation assessing human testicular biopsies.<br

Médecines complémentaires dans le canton de Vaud : recours et offres actuels, principaux enjeux sanitaires et possibilités de réglementation.

Selon les données de l'Enquête suisse sur la santé (ESS), le canton de Vaud comprend une des plus grandes proportions d'utilisateurs de médecines complémentaires « au cours des 12 derniers mois » en Suisse (30% en 2012). L'homéopathie, la phytothérapie et l'acupuncture sont les thérapies les plus prisées. L'auto-recours dans le domaine des médecines complémentaires est difficile à estimer. Sur la base des quelques études disponibles en Suisse, ce phénomène paraît néanmoins fréquent. Selon une enquête téléphonique conduite auprès d'un échantillon représentatif d'adultes en Suisse, seuls 34% des répondant/es consultant des thérapeutes non-médecins affirment en informer toujours leurs médecins traitants

EU Referendums in Context: What can we learn from the Swiss Case?

This is the author accepted manuscript. The final version is available from Wiley via the DOI in this recordThe rising number of referendums on EU matters, such as the Brexit and the Catalonian independence votes, highlight the increasing importance of referendums as a problem‐solving mechanism in the EU. We argue that the Swiss case provides essential insights into understanding the dynamics behind referendums, which are often lacking when referendums are called for in the EU. Referendums in EU member states on EU matters differ substantially from the in Swiss context. Nevertheless, proponents of more direct democratic decision‐making regularly cite the Swiss example. Our systematic analysis of why referendums are called, how they unfold and their resulting effects in the EU and Switzerland reveals that the EU polity lacks the crucial conditions that embed direct democracy within the wider political and institutional system. The comparative perspective offers fundamental insights into the pre‐conditions required for direct democracy to function and its limitations in the EU

A theory of natural intelligence

Introduction: In contrast to current AI technology, natural intelligence – the kind of autonomous intelligence that is realized in the brains of animals and humans to attain in their natural environment goals defined by a repertoire of innate behavioral schemata – is far superior in terms of learning speed, generalization capabilities, autonomy and creativity. How are these strengths, by what means are ideas and imagination produced in natural neural networks? Methods: Reviewing the literature, we put forward the argument that both our natural environment and the brain are of low complexity, that is, require for their generation very little information and are consequently both highly structured. We further argue that the structures of brain and natural environment are closely related. Results: We propose that the structural regularity of the brain takes the form of net fragments (self-organized network patterns) and that these serve as the powerful inductive bias that enables the brain to learn quickly, generalize from few examples and bridge the gap between abstractly defined general goals and concrete situations. Conclusions: Our results have important bearings on open problems in artificial neural network researc