Dermal benefits of topical D-ribose

Our aging skin undergoes changes with reductions in collagenous and elastic fibers, fibroblasts, mast cells, and macrophages with free radical production, which can result in reduced skin tone and wrinkle formation. Fibroblasts are important for dermal integrity and function with a decrease in function producing less skin tone, thinning, and wrinkle formation. Dermal levels of adenosine triphosphate (ATP) decline with aging, potentially altering dermal function. Supplemental D-ribose, a natural occurring carbohydrate, enhances ATP regeneration. D-ribose-based studies demonstrated benefits in both cell culture fibroblastic activities and a subsequent clinical study in women with decreased skin tone with wrinkles. Supplemental D-ribose may offer this needed cellular benefit

Chief Justice Fred M. Vinson of Kentucky: A Political Biography

Fred M. Vinson, the thirteenth Chief Justice of the United States, started his political career as a small-town Kentucky lawyer and rose to positions of power in all three branches of federal government. Born in Louisa, Kentucky, Vinson earned undergraduate and law degrees from Centre College in Danville. He served 12 years in the U.S. House of Representatives, where he achieved acclaim as a tax and fiscal expert. President Roosevelt appointed him to the U.S. Circuit Court of Appeals for the District of Columbia and later named him to key executive-branch positions. President Truman appointed him Secretary of the Treasury and then Chief Justice. The Vinson court was embroiled in critical issues affecting racial discrimination and individual rights during the cold war. Chief Justice Fred M. Vinson of Kentucky: A Political Biography offers a wealth of insight into one of the most significant and highly regarded political figures to emerge from Kentucky. James E. St. Clair is associate professor of journalism at Indiana University Southeast. Linda C. Gugin is professor of political science at Indiana University Southeast. At long last we have a first-rate biography of Fred Vinson that accounts for his significance in a thorough and readable fashion. Students of the U.S. Supreme Court, World War II, and American and Kentucky politics will profit from this book. —Robert M. Ireland This book conveys his life and times effectively. —Appalachian Heritage Presents a memorable portrait of an admirable in unappreciated statesman. —Appellate Practice Journal Provides a sympathetic, easily read portrait of a small-town lawyer who rose to the top levels of all three branches of federal government. —Centrepiece This readable biography of an eminent Kentuckian corrects this oversight to a significant degree and provides the basis for re-examining Vinson’s reputation. . . . An engaging narrative. —David J. Bodenhamer Frederick Moore Vinson (1890-1953) was the thirteenth chief justice of the United States (1946-1953), and, until now, the only one of that number without a full biography. —H-New Reviews A highly readable, balanced biography. . . . A useful addition to all libraries. —Journal of American History Their excellent biography is dedicated largely to showing the Vinson ‘was so much more’ than just head of the American judiciary from 1946 to 1953, for his pubic career prior to that had spanned a quarter-century and was among the most distinguished of his time. . . . A superb and much-needed contribution to political and judicial history. —Journal of Southern History The first in-depth analysis of Fred M. Vinson, Kentucky’s only chief justice of the United States. —Kentucky Monthly Provides a basis for reevaluating Vinson’s reputation as a failure on the Supreme Court. . . . This is a ‘must read’ for anyone who hopes to understand the Vinson court. —Law and Politics Book Review Meticulously assimilates—for the first time in a single source—an erudite yet accessible comparative analysis examining Vinson’s largely overlooked but pioneering roles in developing modern governmental functions. —Leo St. Clair and Gugin provide a sympathetic, easily read portrait of a successful and devoted public servant. Even half a century after his death, Vinson remains a model worthy of emulation. —Lexington Herald-Leader Opens a path for others to tread as the varied career of the most famous Kentuckian you’ve never heard of increasingly comes to light. —Louisville Courier-Journalhttps://uknowledge.uky.edu/upk_law/1005/thumbnail.jp

A Case of Bowen’s Disease and Small-Cell Lung Carcinoma: Long-Term Consequences of Chronic Arsenic Exposure in Chinese Traditional Medicine

Chronic arsenic toxicity occurs primarily through inadvertent ingestion of contaminated water and food or occupational exposure, but it can also occur through medicinal ingestion. This case features a 53-year-old lifetime nonsmoker with chronic asthma treated for 10 years in childhood with Chinese traditional medicine containing arsenic. The patient was diagnosed with Bowen’s disease and developed extensive-stage small-cell carcinoma of the lung 10 years and 47 years, respectively, after the onset of arsenic exposure. Although it has a long history as a medicinal agent, arsenic is a carcinogen associated with many malignancies including those of skin and lung. It is more commonly associated with non–small-cell lung cancer, but the temporal association with Bowen’s disease in the absence of other chemical or occupational exposure strongly points to a causal role for arsenic in this case of small-cell lung cancer. Individuals with documented arsenic-induced Bowen’s disease should be considered for more aggressive screening for long-term complications, especially the development of subsequent malignancies

Assessment of Hematological and Biochemical parameters with extended D-Ribose ingestion

D-ribose, a naturally occurring pentose carbohydrate, has been shown to replenish high- energy phosphates following myocardial ischemia and high intensity, repetitive exercise. Human studies have mainly involved short-term assessment, including potential toxicity. Reports describing adverse effects of D-ribose with prolonged ingestion have been lacking. Therefore, this study assessed the toxicity of extended consumption of D-ribose in healthy adults. Nineteen subjects ingested 20 grams/Day (10 grams, twice a Day) of ribose with serial measurements of biochemical and hematological parameters at Days 0, 7, and 14. No significant toxic changes over the 14-day assessment period occurred in complete blood count, albumin, alkaline phosphatase, gamma glutamyltransferase, alanine amiotransferase, and aspartate aminotransferase. However, D-ribose did produce an asymptomatic, mild hypoglycemia of short duration. Uric acid levels increased at Day 7, but decreased to baseline values by Day 14. D-ribose consumption for 14 days appears not to produce significant toxic changes in both hematological and biochemical parameters in healthy human volunteers

Defending the Humanities: Making a Case for Eighteenth-Century Studies

While the percentage of humanities majors has long been on the decline, the more recent experiences of the Great Recession, its aftermath, and the outbreak of Covid-19 have introduced a variety of daunting and intertwined challenges to scholars in these disciplines. Financial and occupational anxieties surrounding higher education threaten not only to crowd out humanities departments but also to alter the very understanding of what higher education is. While some students attend college to prepare themselves for engaged citizenship or to learn in a community, many also attend as a pathway to employment and expect a prompt return on investment. Moreover, state-level disinvestment contributes to higher tuition fees and student debt, heightening an emphasis on immediate job outcomes to the detriment of the humanities, which typically do not offer study-to-job pipelines. Such financial and legislative divestment can lead to falling enrollments within and cuts to humanities departments, simultaneously reflecting and confirming the public perception that humanistic study is impractical. While humanists have long sought to stem this decline, scholars of the eighteenth century may be uniquely positioned to innovate pragmatic solutions because of the historical period we study. First, eighteenth-century Europe experienced political and economic phenomena that parallel trends in our own era. In England alone, eighteenth-century society faced sharp financial downturns, rising inequities, unfit political leaders, moribund statutes, and new technologies that abetted entrenched class structures. Second, scholars of the eighteenth century have a model of interdisciplinarity and innovation in Enlightenment philosophes, who were not siloed within discrete disciplines as we are today and so were more able and willing to think across epistemological categories. By drawing upon our knowledge of eighteenth-century culture, the following essays seek both to open an inquiry into the decline of the humanities and to provide potential solutions to it. They grew out of a roundtable discussion held at the March 2018 Annual Meeting of the American Society for Eighteenth-Century Studies. In publishing this forum, we hope to continue the expansive and ambitious conversation begun in Orlando, Florida. As scholars of the eighteenth century, we seek to apply the interdisciplinary insights drawn from our research to help strengthen the humanities, especially within those academic institutions that have neither expansive funds nor research-intensive aims. As these authors argue, today’s humanists face extremely high stakes but also abundant possibilities

Inclusive Online Learning in Australia: Barriers and Enablers

While the pandemic highlighted the critical role technology plays in children's lives, not all Australian children have reliable access to technology. This situation exacerbates educational disadvantage for children who are already amongst our nation's most vulnerable. In this research project, we carried out a pilot project with three schools in Western Australia, conducting a series of workshops and interviews with students, parents, school staff members, and teachers. Drawing on rich empirical material, we identify key barriers and enablers for digitally inclusive online learning at the individual, interpersonal, organizational, and infrastructural levels. Of particular importance is that technology is only part of this story - an array of social, environmental, and skills "infrastructure" is needed to facilitate inclusive online learning. Building on this finding, we ran a Digital Inclusion Studio to address this holistic set of issues with strongly positive feedback from participants. We conclude with a set of recommendations for stakeholders (parents, schools, government agencies) who wish to support more digitally inclusive learning.Comment: 22 pages, 1 figur

Exploration de l'utilisation par les étudiants en médecine des principes d'auto-explication et de réflexion structurée pendant l'externat

Background: While educators observe gaps in clerkship students’ clinical reasoning (CR) skills, students report few opportunities to develop them. This study aims at exploring how students who used self-explanation (SE) and structured reflection (SR) for CR learning during preclinical training, applied these learning strategies during clerkship. Methods: We conducted an explanatory sequential mixed-methods study involving medical students. With a questionnaire, we asked students how frequently they adopted behaviours related to SE and SR during clerkship. Next, we conducted a focus group with students to explore why they adopted these behaviours. Results:  Fifty-two of 198 students answered the questionnaire and five participated in a focus group. Specific behaviours adopted varied from 50% to 98%. We identified three themes about why students used these strategies: as “just in time” learning strategies; to deepen their understanding and identify gaps in knowledge; to develop a practical approach to diagnosis. A fourth theme related to the balance between learning and assessment and its consequence on adopting SE behaviours. Conclusions: Students having experienced SE and SR regularly in preclinical training tend to transpose these strategies into the clerkship providing them with a practical way to reflect deliberately and capture learning opportunities of the unpredictable clinical context.Contexte : Alors que les éducateurs observent des lacunes dans les compétences de raisonnement clinique (RC) des étudiants en externat, ces derniers font état de peu d'occasions de les développer. Cette étude vise à explorer comment les étudiants qui ont utilisé l'auto-explication (SE) et la réflexion structurée (SR) pour l'apprentissage du raisonnement clinique pendant la formation préclinique, ont appliqué ces stratégies d'apprentissage pendant l'externat. Méthodes : Nous avons mené une étude séquentielle explicative à méthodes mixtes auprès d'étudiants en médecine. À l'aide d'un questionnaire, nous avons demandé aux étudiants à quelle fréquence ils adoptaient des comportements liés à la SE et à la RS pendant l'externat. Ensuite, nous avons organisé un groupe de discussion avec les étudiants afin d'explorer les raisons pour lesquelles ils ont adopté ces comportements. Résultats : Cinquante-deux étudiants sur 198 ont répondu au questionnaire et cinq ont participé à un groupe de discussion. Les comportements spécifiques adoptés variaient de 50 % à 98 %. Nous avons identifié trois thèmes concernant les raisons pour lesquelles les étudiants ont utilisé ces stratégies : comme stratégies d'apprentissage "juste à temps" ; pour approfondir leur compréhension et identifier les lacunes dans les connaissances ; pour développer une approche pratique du diagnostic. Un quatrième thème concernait l'équilibre entre l'apprentissage et l'évaluation et ses conséquences sur l'adoption de comportements SE. Conclusions : Les étudiants qui ont fait l'expérience de l'ES et de la RS régulièrement au cours de leur formation préclinique ont tendance à transposer ces stratégies dans l'externat, ce qui leur fournit un moyen pratique de réfléchir délibérément et de saisir les opportunités d'apprentissage dans un contexte clinique imprévisible

Child Welfare, Domestic Violence and Substance Abuse: A Review of the Literature, Promising Practices and Strategies

The purpose of this second and final report by the Project is to provide a synopsis of trends, promising practices and programs from across the nation and in Maine related to child abuse/neglect, domestic violence and substance abuse. The report illustrates that Maine is not alone in grappling with these problems. The report is intended, however, to offer several examples of what has been tried and what has been learned by other states and professionals over the past several years. A special emphasis has been placed on services and strategies that have utilized collaborative models of training and program development/delivery