Introduction of a new model for time-continuous and non-contact investigations of in-vitro thrombolysis under physiological flow conditions

<p>Abstract</p> <p>Background</p> <p>Thrombolysis is a dynamic and time-dependent process influenced by the haemodynamic conditions. Currently there is no model that allows for time-continuous, non-contact measurements under physiological flow conditions. The aim of this work was to introduce such a model.</p> <p>Methods</p> <p>The model is based on a computer-controlled pump providing variable constant or pulsatile flows in a tube system filled with blood substitute. Clots can be fixed in a custom-built clot carrier within the tube system. The pressure decline at the clot carrier is measured as a novel way to measure lysis of the clot. With different experiments the hydrodynamic properties and reliability of the model were analyzed. Finally, the lysis rate of clots generated from human platelet rich plasma (PRP) was measured during a one hour combined application of diagnostic ultrasound (2 MHz, 0.179 W/cm²) and a thrombolytic agent (rt-PA) as it is commonly used for clinical sonothrombolysis treatments.</p> <p>Results</p> <p>All hydrodynamic parameters can be adjusted and measured with high accuracy. First experiments with sonothrombolysis demonstrated the feasibility of the model despite low lysis rates.</p> <p>Conclusions</p> <p>The model allows to adjust accurately all hydrodynamic parameters affecting thrombolysis under physiological flow conditions and for non-contact, time-continuous measurements. Low lysis rates of first sonothrombolysis experiments are primarily attributable to the high stability of the used PRP-clots.</p

Managers’ Citizenship Behaviors for the Environment: A Developmental Perspective

International audienc

Personality preferences and their relationship to ego development in Australian leadership program participants

The growth of adult ego development to post-conventional levels is associated with many adaptive advantages for the individual and society. However, the vast majority of adults across a wide range of samples demonstrate ego stages well below the maximum potential. In an effort to advance understanding of why and how development to higher ego levels might occur for some individuals and not others, we explored whether particular personality preferences and combinations thereof (as measured by the Myers-Briggs Type Indicator or MBTI) are associated with higher ego levels and whether particular personality preferences might act as inhibiting or facilitating factors in ego development. Participants were 374 adults (aged 18-61; 50 % female) undertaking 11 community leadership development and 2 professional management development programs. After adjusting for effects of age and education, a preference for Intuition on the MBTI was associated with significantly higher ego development on program entry and with greater ego development during the programs. These results are consistent with previous research and provide support for Manners' and Durkin's (Developmental Review, 20:475-513, 2000) proposal that dispositional personality characteristics may enhance or constrain ego development. © 2013 Springer Science+Business Media New York.Niki Vincent, Lynn Ward, Linley Denso