El papel socioeconómico de las universidades parisinas medievales a través de la base de datos Studium Parisiense

Studium Parisiense is a database which intends to identify all the students and masters of Paris university. With nearly 20000 files, it may be half-way. We have tested this results in exploring the impact of the college system in medieval Paris. A chronological trend appears: the development of the college system in the 14th century is a more efficient solution to accommodate the growing academic population than the creation of the Augustinian canons houses (12th century), and of the mendicant convents (13th century). On the other hand, both in terms of international recruitment and of literary outputs, Paris colleges were inferior institutions, with the exception of the Sorbonne. However, it helped to provide better conditions of study and to discipline the student’s population on the left banks of the Seine, and by the end of the fifteenth century, Paris colleges had increased their reputation and attracted again European students.college; university; Paris; mendicant convents; studentsStudium Parisiense es una base de datos cuyo objetivo es el de identificar a todos los estudiantes y maestros de la Universidad de París. Aún por concluir, cuenta hoy con 20000 fichas. En base a estos datos, se ha intentado medir el impacto del sistema de colegios mayores en el París medieval. El resultado logrado apunta a una tendencia cronológica: el desarrollo del sistema de colegios mayores en el siglo XIV resulta ser una solución más eficaz para acoger a la creciente población académica que la creación de casas de canónigos agustinos (siglo XII) y la de conventos mendicantes (siglo XIII). Por otro lado, tanto en términos de reclutamiento internacional como de producción literaria, salvo la excepción de la Sorbona, los colegios mayores parisinos no dejaban de ser instituciones de segundo nivel. Sin embargo, estas instituciones, situadas en la ribera izquierda del Sena, proporcionaron mejores condiciones de estudio a la población estudiantil y ayudaron a disciplinarla. A finales del siglo XV, los colegios mayores parisinos lograron mejorar su reputación y atraer de nuevo estudiantes europeos

A New Principle for Information Storage in an Enzymatic Pathway Model

Strong experimental evidence indicates that protein kinase and phosphatase (KP) cycles are critical to both the induction and maintenance of activity-dependent modifications in neurons. However, their contribution to information storage remains controversial, despite impressive modeling efforts. For instance, plasticity models based on KP cycles do not account for the maintenance of plastic modifications. Moreover, bistable KP cycle models that display memory fail to capture essential features of information storage: rapid onset, bidirectional control, graded amplitude, and finite lifetimes. Here, we show in a biophysical model that upstream activation of KP cycles, a ubiquitous mechanism, is sufficient to provide information storage with realistic induction and maintenance properties: plastic modifications are rapid, bidirectional, and graded, with finite lifetimes that are compatible with animal and human memory. The maintenance of plastic modifications relies on negligible reaction rates in basal conditions and thus depends on enzyme nonlinearity and activation properties of the activity-dependent KP cycle. Moreover, we show that information coding and memory maintenance are robust to stochastic fluctuations inherent to the molecular nature of activity-dependent KP cycle operation. This model provides a new principle for information storage where plasticity and memory emerge from a single dynamic process whose rate is controlled by neuronal activity. This principle strongly departs from the long-standing view that memory reflects stable steady states in biological systems, and offers a new perspective on memory in animals and humans

A Type I and Type II microsatellite linkage map of Rainbow trout (Oncorhynchus mykiss) with presumptive coverage of all chromosome arms

BACKGROUND: The development of large genomic resources has become a prerequisite to elucidate the wide-scale evolution of genomes and the molecular basis of complex traits. Linkage maps represent a first level of integration and utilization of such resources and the primary framework for molecular analyses of quantitative traits. Previously published linkage maps have already outlined the main peculiarities of the rainbow trout meiosis and a correspondance between linkage groups and chromosome arms has been recently established using fluorescent in situ hybridization. The number of chromosome arms which were covered by these maps remained unknown. RESULTS: We report an updated linkage map based on segregation analysis of more than nine hundred microsatellite markers in two doubled haploid gynogenetic lines. These markers segregated into 31 linkage groups spanning an approximate total map length of 2750 cM. Centromeres were mapped for all the linkage groups using meiogenetic lines. For each of the 31 linkage groups, the meta or acrocentric structure infered from centromere mapping was identical with those recently found with fluorescent in situ hybridization results. The present map is therefore assumed to cover the 52 chromosome arms which constitute the rainbow trout karyotype. Our data confirm the occurrence of a high interference level in this species. Homeologous regions were identified in eleven linkage groups, reflecting the tetraploid nature of the salmonid genome. The data supported the assumption that gene orders are conserved between duplicated groups and that each group is located on a single chromosome arm. Overall, a high congruence with already published rainbow trout linkage maps was found for both gene syntenies and orders. CONCLUSION: This new map is likely to cover the whole set of chromosome arms and should provide a useful framework to integrate existing or forthcoming rainbow trout linkage maps and other genomic resources. Since very large numbers of EST containing microsatellite sequences are available in databases, it becomes feasible to construct high-density linkage maps localizing known genes. This will facilitate comparative mapping and, eventually, identification of candidate genes in QTL studies

Surface plasmon polaritons and surface phonon polaritons on metallic and semiconducting spheres: Exact and semiclassical descriptions

We study the interaction of an electromagnetic field with a non-absorbing or absorbing dispersive sphere in the framework of complex angular momentum techniques. We assume that the dielectric function of the sphere presents a Drude-like behavior or an ionic crystal behavior modelling metallic and semiconducting materials. We more particularly emphasize and interpret the modifications induced in the resonance spectrum by absorption. We prove that "resonant surface polariton modes" are generated by a unique surface wave, i.e., a surface (plasmon or phonon) polariton, propagating close to the sphere surface. This surface polariton corresponds to a particular Regge pole of the electric part (TM) of the S matrix of the sphere. From the associated Regge trajectory we can construct semiclassically the spectrum of the complex frequencies of the resonant surface polariton modes which can be considered as Breit-Wigner-type resonances. Furthermore, by taking into account the Stokes phenomenon, we derive an asymptotic expression for the position in the complex angular momentum plane of the surface polariton Regge pole. We then describe semiclassically the surface polariton and provide analytical expressions for its dispersion relation and its damping in the non-absorbing and absorbing cases. In these analytic expressions, we more particularly exhibit well-isolated terms directly linked to absorption. Finally, we explain why the photon-sphere system can be considered as an artificial atom (a ``plasmonic atom" or "phononic atom") and we briefly discuss the implication of our results in the context of the Casimir effect.Comment: v2: Typos corrected; v3: Paper extended to absorbing media, references added and title change

Resistance to a Rhabdovirus (VHSV) in Rainbow Trout: Identification of a Major QTL Related to Innate Mechanisms

Chantier qualité GAHealth control is a major issue in animal breeding and a better knowledge of the genetic bases of resistance to diseases is needed in farm animals including fish. The detection of quantitative trait loci (QTL) will help uncovering the genetic architecture of important traits and understanding the mechanisms involved in resistance to pathogens. We report here the detection of QTL for resistance to Viral Haemorrhagic Septicaemia Virus (VHSV), a major threat for European aquaculture industry. Two induced mitogynogenetic doubled haploid F2 rainbow trout (Oncorhynchus mykiss) families were used. These families combined the genome of susceptible and resistant F0 breeders and contained only fully homozygous individuals. For phenotyping, fish survival after an immersion challenge with the virus was recorded, as well as in vitro virus replication on fin explants. A bidirectional selective genotyping strategy identified seven QTL associated to survival. One of those QTL was significant at the genome-wide level and largely explained both survival and viral replication in fin explants in the different families of the design (up to 65% and 49% of phenotypic variance explained respectively). These results evidence the key role of innate defence in resistance to the virus and pave the way for the identification of the gene(s) responsible for resistance. The identification of a major QTL also opens appealing perspectives for selective breeding of fish with improved resistance

Present eternity : quests of temporality in the literary production of the "extrême contemporain" in France (The Writings of Dominique Fourcade and Emmanuel Hocquard)

The term \uab extr\ueame contemporain \ubb is an expression currently used by scholars to indicate the French literary production of the last 20 years. This term was used in a work of literature for the first time by the French poet Dominique Fourcade in 1986 (\uc9l\ue9gie L apostrophe E.C.) in reference to an epoch, but also to a new sense of experiencing time and space in the so-called \uab age of digital reproducibility \ubb. The aim of this paper is to consider how the change in temporal protocols due to the triumph of Big Optics (Paul Virilio) affects the sense of teleology (destiny) and the quest for experience in French contemporary poetry (in particular, in the genre of the elegy). Including both memory and anticipation, the \uab extr\ueame contemporain \ubb production seems to prefer the \u201ctime of now\u201d, Jetz-zeit in Benjamin\u2019s words, to past or testimony, and speaks to the present, whose responsibility is to give voice to a space where everything is simply allowed to happen

Overview of the current use of levosimendan in France: a prospective observational cohort study

Abstract Background Following the results of randomized controlled trials on levosimendan, French health authorities requested an update of the current use and side-effects of this medication on a national scale. Method The France-LEVO registry was a prospective observational cohort study reflecting the indications, dosing regimens, and side-effects of levosimendan, as well as patient outcomes over a year. Results The patients included ( n = 602) represented 29.6% of the national yearly use of levosimendan in France. They were treated for cardiogenic shock ( n = 250, 41.5%), decompensated heart failure ( n = 127, 21.1%), cardiac surgery-related low cardiac output prophylaxis and/or treatment ( n = 86, 14.3%), and weaning from veno-arterial extracorporeal membrane oxygenation ( n = 82, 13.6%). They received 0.18 ± 0.07 µg/kg/min levosimendan over 26 ± 8 h. An initial bolus was administered in 45 patients (7.5%), 103 (17.1%) received repeated infusions, and 461 (76.6%) received inotropes and or vasoactive agents concomitantly. Hypotension was reported in 218 patients (36.2%), atrial fibrillation in 85 (14.1%), and serious adverse events in 17 (2.8%). 136 patients (22.6%) died in hospital, and 26 (4.3%) during the 90-day follow-up. Conclusions We observed that levosimendan was used in accordance with recent recommendations by French physicians. Hypotension and atrial fibrillation remained the most frequent side-effects, while serious adverse event potentially attributable to levosimendan were infrequent. The results suggest that this medication was safe and potentially associated with some benefit in the population studied

A model of on/off transitions in neurons of the deep cerebellar nuclei: deciphering the underlying ionic mechanisms

International audienceThe neurons of the deep cerebellar nuclei (DCNn) represent the main functional link between the cerebellar cortex and the rest of the central nervous system. Therefore, understanding the electrophysiological properties of DCNn is of fundamental importance to understand the overall functioning of the cerebellum. Experimental data suggest that DCNn can reversibly switch between two states: the firing of spikes (F state) and a stable depolarized state (SD state). We introduce a new biophysical model of the DCNn membrane electro-responsiveness to investigate how the interplay between the documented conductances identified in DCNn give rise to these states. In the model, the F state emerges as an isola of limit cycles, i.e. a closed loop of periodic solutions disconnected from the branch of SD fixed points. This bifurcation structure endows the model with the ability to reproduce the F → SD transition triggered by hyperpolarizing current pulses. The model also reproduces the F → SD transition induced by blocking Ca currents and ascribes this transition to the blocking of the high-threshold Ca current. The model suggests that intracellular current injections can trigger fully reversible F ↔ SD transitions. Investigation of low-dimension reduced models suggests that the voltage-dependent Na current is prominent for these dynamical features. Finally, simulations of the model suggest that physiological synaptic inputs may trigger F ↔ SD transitions. These transitions could explain the puzzling observation of positively correlated activities of connected Purkinje cells and DCNn despite the former inhibit the latter