Super Fibonacci Graceful Labeling of Some Special Class of Graphs

A Fibonacci graceful labeling and a super Fibonacci graceful labeling on graphs were introduced by Kathiresan and Amutha in 2006

Multi-environment Analysis for Indian Sites

GENOTYPE-BY-ENVIRONMENT interactions (GEI) are ubiquitous for quantitative traits of economic importance. Significant GEI tends to hinder genetic progress in a breeding program; in particular, the crossover type of GEI makes it difficult to unambiguously select promising materials that perform consistently better across a wide range of environmental conditions. The first step to deal with the consequences of the presence of GEI is to assess its relative importance through a pooled analysis of data across the testing sites

Model simulation of tide-induced currents in Gauthami-Godavari estuary

Predictive spatial distribution of flow field has been simulated from the time series data on currents and tides during dry season (11-19, February, 2009) in the Gauthami-Godavari Estuary utilizing TIDAL model. A 2D-Tidal Estuarine model has been considered (instead of 3D model) due to well-mixed type system and its circulation is dominated by tides during the observational period. The model forcing functions consist of wind and tidal elevations along the open boundaries and no fresh water inflow from the main stream and no land flood in river system. The bathymetry data of the river basin has been collected and supplemented to the model as one of the rigid boundary conditions to evaluate integration. The bottom roughness length (K) was adjusted to achieve model calibration and verification in model simulations of flow field. The model simulation results are in qualitative agreement with the observational data with calibrated bottom roughness length which is about 0.085 m. Model results reveal that the majority of flow was found to be along the channel axis (i.e. high iso-bath contour). During flood time, flow is south-west direction and it is changed to northeast direction during ebb period which is indicating that the model results resemble flow in the real eastern system

A Microwatt low voltage bandgap reference for bio-medical applications

In this paper a microwatt low voltage bandgap reference suitable for the bio-medical application. The Present technique relies on the principle of generating CTAT and PTAT without using any (Bipolar Junction Transistor) BJT and adding them with a proper scaling factor for minimal temperature sensitive reference voltage. Beta multiplier reference circuit has been explored to generate CTAT and PTAT. Implemented in 45nm CMOS technology and simulated with Spectre. Simulation results shows that the proposed reference circuit exhibits 1.2% variation at nominal 745mV output voltage. The circuit consumes 16uW from 0.8V supply and occupying 0.004875mm2 silicon area

Pre-seismic, co-seismic and post-seismic displacements associated with the Bhuj 2001 earthquake derived from recent and historic geodetic data

The 26th January 2001 Bhuj earthquake occurred in the Kachchh Rift Basin which has a long history of major earthquakes. Great Triangulation Survey points (GTS) were first installed in the area in 1856-60 and some of these were measured using Global Positioning System (GPS) in the months of February and July 2001. Despite uncertainties associated with repairs and possible reconstruction of points in the past century, the re-measurements reveal pre-seismic, co-seismic and post-seismic deformation related to Bhuj earthquake. More than 25 M-strain contraction north of the epicenter appears to have occurred in the past 140 years corresponding to a linear convergence rate of approximately 10 mm/yr across the Rann of Kachchh. Motion of a single point at Jamnagar 150 km south of the epicenter in the 4 years prior to the earthquake, and GTS-GPS displacements in Kathiawar suggests that pre-seismic strain south of the epicenter was small and differs insignificantly from that measured elsewhere in India. Of the 20 points measured within 150 km of the epicenter, 12 were made at existing GTS points which revealed epicentral displacements of up to 1 m, and strain changes exceeding 30 M-strain. Observed displacements are consistent with reverse co-seismic slip. Re-measurements in July 2001 of one GTS point (Hathria) and eight new points established in February reveal post-seismic deformation consistent with continued slip on the Bhuj rupture zone

Variability in stratification and flushing times of the Gautami–Godavari estuary, India

In order to examine the influence of forcing (river flow and tides) and anthropogenic activities (dredging and dam regulation) on stratification, a study was conducted over a period of 19 months (June 2008–December 2009) in the Gautami–Godavari estuary (G–GE) during spring and neap tide periods covering entire spectrum of discharge over a distance of 36 km from the mouth. The bathymetry of the estuary was recently changed due to dredging of ∼20 km of the estuary from the mouth for transportation of barges. This significantly changed the mean depth and salinity of the estuary from its earlier state. The variations in the distribution of salinity in the Godavari estuary are driven by river discharge during wet period (June–November) and tides during dry period (December–May). The weak stratification was observed during high discharge (July–August) and no discharge (January–June) periods associated with dominant fresh water and marine water respectively. The strong stratification was developed associated with decrease in discharge during moderate discharge period (October–December). Relatively stronger stratification was noticed during neap than spring tides. The 15 psu isohaline was observed to have migrated ∼2–3 km more towards upper estuary during spring than neap tide suggesting more salt enters during former than latter period. Total salt content was inversely correlated with river discharge and higher salt of about 400×106 m3 psu was observed during spring than neap tide. Flushing times varied between less than a day and more than a month during peak and no discharge periods respectively with lower times during spring than neap tide. The flushing times are controlled by river discharge during high discharge period, tides during dry period and both (river discharge and tides) under moderate discharge period. This study suggests that modification of discharge, either natural due to weak monsoon or artificial such as dam constructions and re-routing the river flow, may have significant impact on the stratification and biogeochemistry of the Godavari estuary

Burden and predictors of hypertension in India: results of SEEK (Screening and Early Evaluation of Kidney Disease) study

Background: Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India. Methods: 6120 subjects participated in the Screening and Early Evaluation of Kidney disease (SEEK), a community-based screening program in 53 camps in 13 representative geographic locations in India. Of these, 5929 had recorded blood pressure (BP) measurements. Potential predictors of HTN were collected using a structured questionnaire for SEEK study. Results: HTN was observed in 43.5% of our cohort. After adjusting for center variation (p < 0.0001), predictors of a higher prevalence of HTN were older age ≥40 years (p < 0.0001), BMI of ≥ 23 Kg/M2 (p < 0.0004), larger waist circumference (p < 0.0001), working in sedentary occupation (p < 0.0001), having diabetes mellitus (p < 0.0001), having proteinuria (p < 0.0016), and increased serum creatinine (p < 0.0001). High school/some college education (p = 0.0016), versus less than 9th grade education, was related with lower prevalence of HTN. Of note, proteinuria and CKD were observed in 19% and 23.5% of HTN subjects. About half (54%) of the hypertensive subjects were aware of their hypertension status. Conclusions: HTN was common in this cohort from India. Older age, BMI ≥ 23 Kg/M2, waist circumference, sedentary occupation, education less, diabetes mellitus, presence of proteinuria, and raised serum creatinine were significant predictors of hypertension. Our data suggest that HTN is a major public health problem in India with low awareness, and requires aggressive community-based screening and education to improve health

Untargeted LC-HRMS-based metabolomics to identify novel biomarkers of metastatic colorectal cancer

Colorectal cancer is one of the main causes of cancer death worldwide, and novel biomarkers are urgently needed for its early diagnosis and treatment. The utilization of metabolomics to identify and quantify metabolites in body fluids may allow the detection of changes in their concentrations that could serve as diagnostic markers for colorectal cancer and may also represent new therapeutic targets. Metabolomics generates a pathophysiological ‘fingerprint’ that is unique to each individual. The purpose of our study was to identify a differential metabolomic signature for metastatic colorectal cancer. Serum samples from 60 healthy controls and 65 patients with metastatic colorectal cancer were studied by liquid chromatography coupled to high-resolution mass spectrometry in an untargeted metabolomic approach. Multivariate analysis revealed a separation between patients with metastatic colorectal cancer and healthy controls, who significantly differed in serum concentrations of one endocannabinoid, two glycerophospholipids, and two sphingolipids. These findings demonstrate that metabolomics using liquid-chromatography coupled to high-resolution mass spectrometry offers a potent diagnostic tool for metastatic colorectal cancer.This study was supported by a grant (n° 15CC056/DTS17/00081- ISCIII-FEDER) from the Fundación para la Investigación Biosanitaria de Andalucía Oriental (FIBAO) and Roche Pharma S.L. Authors from the Fundación MEDINA acknowledge the receipt of financial support from this public-private partnership of Merck Sharp & Dohme de España S.A. with the University of Granada and Andalusian Regional Government (PIN-0474-2016)

STEPWISE - STructured lifestyle Education for People WIth SchizophrEnia : a study protocol for a randomised controlled trial

BACKGROUND: People with schizophrenia are two to three times more likely to be overweight than the general population. The UK National Institute of Health and Care Excellence (NICE) recommends an annual physical health review with signposting to, or provision of, a lifestyle programme to address weight concerns and obesity. The purpose of this randomised controlled trial is to assess whether a group-based structured education programme can help people with schizophrenia to lose weight. METHODS: Design: a randomised controlled trial of a group-based structured education programme. SETTING: 10 UK community mental health trusts. PARTICIPANTS: 396 adults with schizophrenia, schizoaffective, or first-episode psychosis who are prescribed antipsychotic medication will be recruited. Participants will be overweight, obese or be concerned about their weight. INTERVENTION: participants will be randomised to either the intervention or treatment as usual (TAU). The intervention arm will receive TAU plus four 2.5-h weekly sessions of theory-based lifestyle structured group education, with maintenance contact every 2 weeks and 'booster' sessions every 3 months. All participants will receive standardised written information about healthy eating, physical activity, alcohol and smoking. OUTCOMES: the primary outcome is weight (kg) change at 1 year post randomisation. Secondary outcomes, which will be assessed at 3 and 12 months, include: the proportion of participants who maintained or reduced their weight; waist circumference; body mass index; objectively measured physical activity (wrist accelerometer); self-reported diet; blood pressure; fasting plasma glucose, lipid profile and HbA1c (baseline and 1 year only); health-related quality of life (EQ-5D-5L and RAND SF-36); (adapted) brief illness perception questionnaire; the Brief Psychiatric Rating Scale; the Client Service Receipt Inventory; medication use; smoking status; adverse events; depression symptoms (Patient Health Questionnaire-9); use of weight-loss programmes; and session feedback (intervention only). Outcome assessors will be blind to trial group allocation. Qualitative interviews with a subsample of facilitators and invention-arm participants will provide data on intervention feasibility and acceptability. Assessment of intervention fidelity will also be performed. DISCUSSION: The STEPWISE trial will provide evidence for the clinical and cost-effectiveness of a tailored intervention, which, if successful, could be implemented rapidly in the NHS. TRIAL REGISTRATION: ISRCTN19447796 , registered on 20 March 2014

Correction: Loss of E-cadherin leads to Id2-dependent inhibition of cell cycle progression in metastatic lobular breast cancer

Following the publication of this article, the authors noted an error in Fig. 6C. The merged (bottom left) panel for the human ILC organoid KCL320, did not display the correct z-plane. The correct merged image has now been provided. The authors confirm this does not affect the conclusions of the study in any way