Modeling Net-Centric System of Systems using the Dystems Modeling Language SysML

Understanding the operations of a large \u27net-centric system-of-systems requires in-depth knowledge of the interfaces among the various systems, sub-systems and components. Architectural modeling can help in reducing the complexity involved in designing such large networked systems. An example of such a complex system is the Global Earth Observation System of Systems (GEOSS) - a system for monitoring and collecting information related to Earth\u27s resources. This paper demonstrates the use of Systems Modeling Language (SysML), which supports specification, analysis, design, verification and validation of a broad range of complex systems, to model some aspects of the GEOSS. The paper discusses issues related to architecture description, development, presentation, and integration for the chosen domain. The paper discusses issues related to model evaluation and how architectures can be simulated to better understand their efficacy

A Methodology for Deriving System Requirements Using Agent Based System Modeling

In this paper, we duscuss a method to derive the requirements for developing an Industrial Automation and Constrol System (IACS). An IACS has software components and associated hardware, which together implement the required monitoring, supervision and control of operations an a production plant. The requirements of such a system are multi-dimensional and may require multiple layers of abstraction. For this domain, we propose an agent-based modeling adopting an agent-based modeling approach is the implicit flexibility afforded by agents and the negotiation techniques that can be implemented to streamline the change management process associated with requirements modeling and analysis. This paper utilizes modeling constructs from UML/SysML to model and visualize the interactions among the agents. The types of agents and their roles are discussed in detail

New way to achieve chaotic synchronization in spatially extended systems

We study the spatio-temporal behavior of simple coupled map lattices with periodic boundary conditions. The local dynamics is governed by two maps, namely, the sine circle map and the logistic map respectively. It is found that even though the spatial behavior is irregular for the regularly coupled (nearest neighbor coupling) system, the spatially synchronized (chaotic synchronization) as well as periodic solution may be obtained by the introduction of three long range couplings at the cost of three nearest neighbor couplings.Comment: 5 pages (revtex), 7 figures (eps, included

Dynamics of an electron in finite and infinite one dimensional systems in presence of electric field

We study,numerically, the dynamical behavior of an electron in a two site nonlinear system driven by dc and ac electric field separately. We also study, numerically, the effect of electric field on single static impurity and antidimeric dynamical impurity in an infinite 1D chain to find the strength of the impurities. Analytical arguments for this system have also been given.Comment: File Latex, 8 Figures available on reques

Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro

Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of chronic fibrotic diseases. However, the mechanism by which paracrine effects of CTGF control the cell fate of neighboring epithelial cells is not known. In this study, we investigated the paracrine effects of CTGF overexpressed in fibroblasts of Col1a2-CTGF transgenic mice on epithelial cells of skin and lung. The skin and lungs of Col1a2-CTGF transgenic mice were examined for phenotypic markers of epithelial activation and differentiation and stimulation of signal transduction pathways. In addition to an expansion of the dermal compartment in Col1a2-CTGF transgenic mice, the epidermis was characterized by focal hyperplasia, and basal cells stained positive for aSMA, Snail, S100A4 and Sox9, indicating that these cells had undergone a change in their genetic program. Activation of phosphorylated p38 and phosphorylated Erk1/2 was observed in the granular and cornified layers of the skin. Lung fibrosis was associated with a marked increase in cells coexpressing epithelial and mesenchymal markers in the lesional and unaffected lung tissue of Col1a2-CTGF mice. In epithelial cells treated with TGFb, CTGF-specific siRNA-mediated knockdown suppressed Snail, Sox9, S100A4 protein levels and restored E-cadherin levels. Both adenoviral expression of CTGF in epithelial cells and treatment with recombinant CTGF induced EMT-like morphological changes and expression of a-SMA. Our in vivo and in vitro data supports the notion that CTGF expression in mesenchymal cells in the skin and lungs can cause changes in the differentiation program of adjacent epithelial cells. We speculate that these changes might contribute to fibrogenesis

HLA-DRB1*15 influences the development of brain tissue damage in early PPMS

OBJECTIVES To investigate whether (1) there were differences between HLA-DRB1*15-positive and -negative patients at baseline, and (2) HLA-DRB1*15-positive patients showed a greater development of brain and spinal cord damage, as assessed by MRI, and greater progression of disability, during a 5-year follow-up, compared with HLA-DRB1*15-negative patients. METHODS HLA-DRB1*15 typing was performed in 41 patients with primary progressive multiple sclerosis (PPMS) who were recruited within 5 years of symptom onset. All patients and 18 healthy controls were studied clinically and with MRI at baseline, and every 6 months for 3 years, and then at 5 years. Magnetization transfer ratio parameters and volumes for brain gray matter and normal-appearing white matter, brain T2 lesion load, and spinal cord cross-sectional area were obtained. Patient disability was assessed at each visit using the Expanded Disability Status Scale and Multiple Sclerosis Functional Composite subscores. RESULTS There were no significant differences between HLA-DRB1*15-positive and -negative patients at baseline. HLA-DRB1*15-positive patients showed a greater decline in brain magnetization transfer ratio for gray matter and normal-appearing white matter (both p = 0.005) than HLA-DRB1*15-negative patients over 5 years, while the same parameters did not change over time in healthy controls. HLA-DRB1*15-positive patients also showed a trend toward a faster increase in brain T2 lesion load than HLA-DRB1*15-negative patients (0.29 [95% confidence interval 0.20-0.38] vs 0.21 [0.13-0.30] mL/mo, p = 0.085) and higher T2 lesion volumes at all time points (average difference [95% confidence interval]: 10.58 mL [7.09-14.07], p < 0.001) during the follow-up, after adjusting for disease duration. CONCLUSIONS These findings suggest that HLA-DRB1*15 influences the progression of brain pathology in PPMS

Hospital admissions for vitamin D related conditions and subsequent immune-mediated disease: record-linkage studies

PMCID: PMC3729414The electronic version of this article is the complete one and can be found online at: http://www.biomedcentral.com/1741-7015/11/171. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Small-world properties of the Indian Railway network

Structural properties of the Indian Railway network is studied in the light of recent investigations of the scaling properties of different complex networks. Stations are considered as `nodes' and an arbitrary pair of stations is said to be connected by a `link' when at least one train stops at both stations. Rigorous analysis of the existing data shows that the Indian Railway network displays small-world properties. We define and estimate several other quantities associated with this network.Comment: 5 pages, 7 figures. To be published in Phys. Rev.

Temperature enhanced persistent currents and "ϕ0/2\phi_0/2 periodicity"

We predict a non-monotonous temperature dependence of the persistent currents in a ballistic ring coupled strongly to a stub in the grand canonical as well as in the canonical case. We also show that such a non-monotonous temperature dependence can naturally lead to a $\phi_0/2$ periodicity of the persistent currents, where $\phi_0$=h/e. There is a crossover temperature $T^*$, below which persistent currents increase in amplitude with temperature while they decrease above this temperature. This is in contrast to persistent currents in rings being monotonously affected by temperature. $T^*$ is parameter-dependent but of the order of $\Delta_u/\pi^2k_B$, where $\Delta_u$ is the level spacing of the isolated ring. For the grand-canonical case $T^*$ is half of that for the canonical case.Comment: some typos correcte

Low temperature Thermodynamics in the Context of Dissipative Diamagnetism

We revisit here the effect of quantum dissipation on the much - studied problem of Landau diamagnetism, and analyze the results in the light of the third law of thermodynamics. The case of an additional parabolic potential is separately assessed. We find that dissipation arising from strong coupling of the system to its environment qualitatively alters the low-temperature thermodynamic attributes such as the entropy and the specific heat