Non-specific cellular uptake of surface-functionalized quantum dots

We report a systematic empirical study of nanoparticle internalization into cells via non-specific pathways. The nanoparticles were comprised of commercial quantum dots (QDs) that were highly visible under a fluorescence confocal microscope. Surface-modified QDs with basic biologically-significant moieties, e.g. carboxyl, amino, streptavidin were used, in combination with the surface derivatization with polyethylene glycol (PEG) in a range of immortalized cell lines. Internalization rates were derived from image analysis and a detailed discussion about the effect of nanoparticle size, charge and surface groups is presented. We find that PEG-derivatization dramatically suppresses the non-specific uptake while PEG-free carboxyl and amine functional groups promote QD internalization. These uptake variations displayed a remarkable consistency across different cell types. The reported results are important for experiments concerned with cellular uptake of surface-functionalized nanomaterials, both when non-specific internalization is undesirable and also when it is intended for material to be internalized as efficiently as possible. Published article at: http://iopscience.iop.org/0957-4484/21/28/285105/Comment: 14 pages 7 figure

Beyond scaling and locality in turbulence

An analytic perturbation theory is suggested in order to find finite-size corrections to the scaling power laws. In the frame of this theory it is shown that the first order finite-size correction to the scaling power laws has following form $S(r) \cong cr^{\alpha_0}[\ln(r/\eta)]^{\alpha_1}$, where $\eta$ is a finite-size scale (in particular for turbulence, it can be the Kolmogorov dissipation scale). Using data of laboratory experiments and numerical simulations it is shown shown that a degenerate case with $\alpha_0 =0$ can describe turbulence statistics in the near-dissipation range $r > \eta$, where the ordinary (power-law) scaling does not apply. For moderate Reynolds numbers the degenerate scaling range covers almost the entire range of scales of velocity structure functions (the log-corrections apply to finite Reynolds number). Interplay between local and non-local regimes has been considered as a possible hydrodynamic mechanism providing the basis for the degenerate scaling of structure functions and extended self-similarity. These results have been also expanded on passive scalar mixing in turbulence. Overlapping phenomenon between local and non-local regimes and a relation between position of maximum of the generalized energy input rate and the actual crossover scale between these regimes are briefly discussed.Comment: extended versio

Hidden-variable theory versus Copenhagen quantum mechanics

The main assumptions the Copenhagen quantum mechanics has been based on will be summarized and the known (not yet decided) contradiction between Einstein and Bohr will be newly analyzed. The given assumptions have been represented basically by time-dependent Schroedinger equation, to which some further assumptions have been added. Some critical comments have been raised against the given mathematical model structure by Pauli (1933) and by Susskind and Glogover (1964). They may be removed if only the Schroedinger equation is conserved and the additional assumptions are abandoned, as shown recently. It seems to be in contradiction to the numerous declarations that the Copenhagen model has been approved by experimental results. However, in the most of these experiments only the agreement with the mere Schroedinger equation has been tested. All mentioned assumptions have been tested practically only in the EPR experiment (measurement of coincidence light transmission through two polarizers) proposed originally by Einstein (1935). Also these experimental results have been interpreted as supporting the Copenhagen alternative, which has not been, however, true. In fact the microscopic world may be described correspondingly only with the help of the hidden-variable theory that is represented by the Schroedinger equation without mentioned additional assumptions, which has the consequence that the earlier interpretation gap between microscopic and macroscopic worlds has been removed. The only difference concerns the existence of discrete states. The possibilities of the human reason of getting to know the nature will be also shortly discussed in the beginning of this contribution.Comment: 10 pages, 2 figures; v2: local refinements and improvements of the tex

Mean- Field Approximation and Extended Self-Similarity in Turbulence

Recent experimental discovery of extended self-similarity (ESS) was one of the most interesting developments, enabling precise determination of the scaling exponents of fully developed turbulence. Here we show that the ESS is consistent with the Navier-Stokes equations, provided the pressure -gradient contributions are expressed in terms of velocity differences in the mean field approximation (Yakhot, Phys.Rev. E{\bf 63}, 026307, (2001)). A sufficient condition for extended self-similarity in a general dynamical systemComment: 8 pages, no figure

The Viscous Lengths in Hydrodynamic Turbulence are Anomalous Scaling Functions

It is shown that the idea that scaling behavior in turbulence is limited by one outer length $L$ and one inner length $\eta$ is untenable. Every n'th order correlation function of velocity differences \bbox{\cal F}_n(\B.R_1,\B.R_2,\dots) exhibits its own cross-over length $\eta_{n}$ to dissipative behavior as a function of, say, $R_1$. This length depends on $n$ {and on the remaining separations} $R_2,R_3,\dots$. One result of this Letter is that when all these separations are of the same order $R$ this length scales like $\eta_n(R)\sim \eta (R/L)^{x_n}$ with $x_n=(\zeta_n-\zeta_{n+1}+\zeta_3-\zeta_2)/(2-\zeta_2)$, with $\zeta_n$ being the scaling exponent of the $n$'th order structure function. We derive a class of scaling relations including the ``bridge relation" for the scaling exponent of dissipation fluctuations $\mu=2-\zeta_6$.Comment: PRL, Submitted. REVTeX, 4 pages, I fig. (not included) PS Source of the paper with figure avalable at http://lvov.weizmann.ac.il/onlinelist.htm

Scaling law of the plasma turbulence with non conservative fluxes

It is shown that in the presence of anisotropic kinetic dissipation existence of scale invariant power law spectrum of plasma turbulence is possible. Obtained scale invariant spectrum is not associated with the constant flux of any physical quantity. Application of the model to the high frequency part of the solar wind turbulence is discussed.Comment: Phys Rev E, accepte

The effect of supplements of groundnut flour or groundnut protein isolate fortified with calcium salts and vitamins or of skim-milk powder on the digestibility coefficient, biological value and net utilization of the proteins of poor Indian diets given to undernourished children

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The metabolism of nitrogen, calcium and phosphorus in undernourished children. 8. The metabolism of nitrogen, calcium and phosphorus, and the digestibility coefficient and biological value of the proteins and the net protein utilization on poor Indian diets based on rice, maize or a mixture of rice and maize

This article does not have an abstract

Persistence of small-scale anisotropy of magnetic turbulence as observed in the solar wind

The anisotropy of magnetophydrodynamic turbulence is investigated by using solar wind data from the Helios 2 spacecraft. We investigate the behaviour of the complete high-order moment tensors of magnetic field increments and we compare the usual longitudinal structure functions which have both isotropic and anisotropic contributions, to the fully anisotropic contribution. Scaling exponents have been extracted by an interpolation scaling function. Unlike the usual turbulence in fluid flows, small-scale magnetic fluctuations remain anisotropic. We discuss the radial dependence of both anisotropy and intermittency and their relationship.Comment: 7 pages, 2 figures, in press on Europhys. Let

A study of vitamin B<SUB>12</SUB> protection in experimental liver injury to the rat by carbon tetrachloride

This article does not have an abstract