James Russel Wilson Sr. Papers - Accession 322

The collection consists of correspondence, real estate and land records, Federal Land Bank abstracts, land plats, clippings and other material. It is a valuable source of Lancaster County, South Carolina, especially Indian Land History. Mr. Wilson owned a large amount of land in Lancaster County and there is a substantial amount of titles, deeds, and other records of real estate transactions dating back to 1887. There are also a number of quite precise plats and maps. Mr. Wilson’s papers could be of genealogical interest.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1399/thumbnail.jp

A FIRST-OCCUPANCY REPRESENTATION FOR REINFORCEMENT LEARNING

Both animals and artificial agents benefit from state representations that support rapid transfer of learning across tasks and which enable them to efficiently traverse their environments to reach rewarding states. The successor representation (SR), which measures the expected cumulative, discounted state occupancy under a fixed policy, enables efficient transfer to different reward structures in an otherwise constant Markovian environment and has been hypothesized to underlie aspects of biological behavior and neural activity. However, in the real world, rewards may only be available for consumption once, may shift location, or agents may simply aim to reach goal states as rapidly as possible without the constraint of artificially imposed task horizons. In such cases, the most behaviorally-relevant representation would carry information about when the agent was likely to first reach states of interest, rather than how often it should expect to visit them over a potentially infinite time span. To reflect such demands, we introduce the first-occupancy representation (FR), which measures the expected temporal discount to the first time a state is accessed. We demonstrate that the FR facilitates exploration, the selection of efficient paths to desired states, allows the agent, under certain conditions, to plan provably optimal trajectories defined by a sequence of subgoals, and induces similar behavior to animals avoiding threatening stimuli

Building from the Ground Up: Creating Effective Programs to Mentor Children of Prisoners (The Amachi Model)

Drawing from P/PVs five years of hands-on experience designing and implementing Amachi programs around the country, Building From The Ground Up describes best practices for planning, developing and managing a mentoring-children-of-prisoners program. This guidebook is essential for learning the professional procedures, standards and administrative tools required to have an effective program

A dynamic spatial model of conflict escalation

In both historical and modern conflicts, space plays a critical role in how interactions occur over time. Despite its importance, the spatial distribution of adversaries has often been neglected in mathematical models of conflict. In this paper, we propose an entropy-maximising spatial interaction method for disaggregating the impact of space, employing a general notion of ‘threat’ between two adversaries. This approach addresses a number of limitations that are associated with partial differential equation approaches to spatial disaggregation. We use this method to spatially disaggregate the Richardson model of conflict escalation, and then explore the resulting model with both analytical and numerical treatments. A bifurcation is identified that dramatically influences the resulting spatial distribution of conflict and is shown to persist under a range of model specifications. Implications of this finding for real-world conflicts are discussed

The Ursinus Weekly, February 26, 1962

Jean Dillin wins Weekly contest • Sororities welcome 14 new members; 43 men accept frat bids this afternoon • Beardwood chemistry club hears Dr. Levie Van Dam • Two Ursinus women offer Summer teaching position on Indian reservations • Colors presented to new UC women • Patti Whittick elected May queen; JoAnn Lewis unopposed May manager • Philadelphia rabbi participates in religious emphasis week • Charities chosen for Campus Chest • Wire manufacturer appears for ACES • Student teachers hear C-T principal • Clinic Day unqualified success • Editorial: Dual roles • Lycoming College to hold music fete • Ursinus in the past • Pearson, Williams named WSGA, WAA representatives • Cabinet of Y receives two day study choices • Veterinarian work topic for pre-med. society guest • Cooler breezes consort in Austria and Germany • Leber-South leads dorm cage league • Maids swim, dive for two victories • MASCAC wrestling tickets on sale • Grapplers pound PMC, 32-0; Dean, Powers still unbeaten • Hoopsters winless in week\u27s action; Delaware, Drexel drub Grizzlies • Women split two tilts; West Chester cagers win • Track team runs early indoor meets • Collegeville tops Phoenix YMCA basketball league • Collegeville Girl Scouts hear Mrs. Ned Seelye • 17 Collegeville firemen at Phila. fire school • Charles H. Noss, Ursinus Director, dies suddenlyhttps://digitalcommons.ursinus.edu/weekly/1312/thumbnail.jp

The structure of the RbBP5 β-propeller domain reveals a surface with potential nucleic acid binding sites

The multi-protein complex WRAD, formed by WDR5, RbBP5, Ash2L and Dpy30, binds to the MLL SET domain to stabilize the catalytically active conformation required for histone H3K4 methylation. In addition, the WRAD complex contributes to the targeting of the activated complex to specific sites on chromatin. RbBP5 is central to MLL catalytic activation, by making critical contacts with the other members of the complex. Interestingly its only major structural domain, a canonical WD40 repeat -propeller, is not implicated in this function. Here, we present the structure of the RbBP5 -propeller domain revealing a distinct, feature rich surface, dominated by clusters of Arginine residues. Our nuclear magnetic resonance binding data supports the hypothesis that in addition to the role of RbBP5 in catalytic activation, its -propeller domain is a platform for the recruitment of the MLL complexes to chromatin targets through its direct interaction with nucleic acids