Electrochemical study of some 2,5-dimethoxyamphetamine derivatives

A set of 2,5-dimethoxyamphetamines differing in their substitution at C4 was studied by differential pulse voltammetry and linear scan cyclic voltammetry in aqueous media. These experiments showed a single oxydation peak for each of the compounds studied. This peak is attributed to oxidation of the aromatic ring with formation of a radical cation stabilized by the methoxy group bonded to the benzene ring

GSH : Electrochemical assessment of adduct formation with nimodipine and propranolol

The present paper demonstrates through voltammetric methods and UV spectroscopy the feasibility of the in vitro adduct formation Glutathione-Nimodipine and Glutathione- Propranolol in absence of enzymatic catalysis. The effect of pH, temperature and reaction media on the adduct formation is assessed. Under physiological canditions (pH 7.4, 37°C) the apparent affinity constants were: Kapp GSH-NMD= 1.21-106 M-1; Kapp GSH-PRP=7.64-103 M_1 and a 1:1 molar ratio for both interactions were found. Thermodynamic data indicate that the adduct formations were spontaneous