Socially Engaged Oral History Pedagogy amid the COVID-19 Pandemic

In response to the OHR editors’ prompt regarding important considerations for teaching oral history during disasters and pandemics, this article presents a case study model for developing socially engaged and collaborative pedagogy that centers on the ethics of conducting oral history in the present moment of crisis and hiatus. Central to our oral history research and pedagogical concerns about teaching during the COVID-19 pandemic are inquiries such as, what conditions create an ethical time for recording history? How can we use oral histories about the pandemic to address the normalized conditions of precarity and instability that millions in the United States and around the world face on a daily basis? In addressing these concerns, we also gesture towards developing a participatory mode of history making that redresses historical erasure, misrepresentation, and underrepresentation

Zilpaterol and Ractopamine: Reaching Consensus on Trace-Level Transfers to Racehorses

In this article, we review the investigation of trace amounts of b-2 adrenergic agonists, a drug class that possess significant risk to the integrity of horse racing whether intentionally used or through the inadvertent contamination of feed

LRRTM3 Interacts with APP and BACE1 and Has Variants Associating with Late-Onset Alzheimer's Disease (LOAD)

Leucine rich repeat transmembrane protein 3 (LRRTM3) is member of a synaptic protein family. LRRTM3 is a nested gene within α-T catenin (CTNNA3) and resides at the linkage peak for late-onset Alzheimer’s disease (LOAD) risk and plasma amyloid β (Aβ) levels. In-vitro knock-down of LRRTM3 was previously shown to decrease secreted Aβ, although the mechanism of this is unclear. In SH-SY5Y cells overexpressing APP and transiently transfected with LRRTM3 alone or with BACE1, we showed that LRRTM3 co-localizes with both APP and BACE1 in early endosomes, where BACE1 processing of APP occurs. Additionally, LRRTM3 co-localizes with APP in primary neuronal cultures from Tg2576 mice transduced with LRRTM3-expressing adeno-associated virus. Moreover, LRRTM3 co-immunoprecipitates with both endogenous APP and overexpressed BACE1, in HEK293T cells transfected with LRRTM3. SH-SY5Y cells with knock-down of LRRTM3 had lower BACE1 and higher CTNNA3 mRNA levels, but no change in APP. Brain mRNA levels of LRRTM3 showed significant correlations with BACE1, CTNNA3 and APP in ∼400 humans, but not in LRRTM3 knock-out mice. Finally, we assessed 69 single nucleotide polymorphisms (SNPs) within and flanking LRRTM3 in 1,567 LOADs and 2,082 controls and identified 8 SNPs within a linkage disequilibrium block encompassing 5′UTR-Intron 1 of LRRTM3 that formed multilocus genotypes (MLG) with suggestive global association with LOAD risk (p = 0.06), and significant individual MLGs. These 8 SNPs were genotyped in an independent series (1,258 LOADs and 718 controls) and had significant global and individual MLG associations in the combined dataset (p = 0.02–0.05). Collectively, these results suggest that protein interactions between LRRTM3, APP and BACE1, as well as complex associations between mRNA levels of LRRTM3, CTNNA3, APP and BACE1 in humans might influence APP metabolism and ultimately risk of AD.© 2013 Lincoln et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Meddlesome Practices Landing Page Text for Continental Group Project

Spanning seventy years of the Continental Can Company, oral histories with 226 employees illustrate the type of research and practice the Oral History Research Office (OHRO) conducted for many of its own formative years. Major companies would contract with the OHRO to conduct interviews about its history and operations. In that sense, if according to U.S. legal doctrine, “corporations are people,” it makes sense to consider corporations as the subject of an oral history interview and ask narrators to comment on the corporation. Learn more about this collection in the Columbia Libraries Catalog (CLIO): https://clio.columbia.edu/catalog/407254