7 research outputs found
Respiratory symptoms do not reflect functional impairment in early CF lung disease.
BACKGROUND
Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known.
METHODS
We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life.
RESULTS
We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms.
CONCLUSIONS
We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone
ZĂĽrcher Transition von Patienten mit Zystischer Fibrose vom Âpädiatrischen ins adulte Zentrum
Heutzutage liegt die Lebenserwartung von Patienten mit Zystischer Fibrose deutlich höher als noch vor wenigen Jahrzehnten – ein Grossteil der Betroffenen erreicht das mittlere Erwachsenenalter. Eine gut vorbereitete Transition in die Erwachsenenmedizin ist deshalb essentiell für die pädiatrischen Patienten
Respiratory symptoms do not reflect functional impairment in early CF lung disease
BACKGROUND
Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known.
METHODS
We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life.
RESULTS
We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p=0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms.
CONCLUSIONS
We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone