Gendered migrations, social reproduction and the household in Europe

The global chains of care has become a favoured theoretical lens to capture the global transfer of physical and emotional labour from less wealthy regions but has tended to channel research into a narrow set of sectors, skills and sites which intersect with the household. We need to unpack what is actually happening in the household in a period of economic, social and political change in which inequalities have increased massively and state intervention is reshaping how and what activities are undertaken in particular sites and institutions. Revisiting the concept of social reproduction enables us to better appreciate the complexity of the transfer of labour institutionally and spatially

cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood

Cyclic GMP (cGMP) is a second messenger that regulates numerous physiological and pathophysiological processes. In recent years, more and more studies have uncovered multiple roles of cGMP signalling pathways in the somatosensory system. Accumulating evidence suggests that cGMP regulates different cellular processes from embryonic development through to adulthood. During embryonic development, a cGMP-dependent signalling cascade in the trunk sensory system is essential for axon bifurcation, a specific form of branching of somatosensory axons. In adulthood, various cGMP signalling pathways in distinct cell populations of sensory neurons and dorsal horn neurons in the spinal cord play an important role in the processing of pain and itch. Some of the involved enzymes might serve as a target for future therapies. In this review, we summarise the knowledge regarding cGMP-dependent signalling pathways in dorsal root ganglia and the spinal cord during embryonic development and adulthood, and the potential of targeting these pathways. LINKED ARTICLES This article is part of a themed issue on cGMP Signalling in Cell Growth and Survival. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.11/issueto