A Methodology for Assessing Eco-efficiency in Logistics Networks

Recent literature on sustainable logistics networks points to two important questions: (i) How to spot the preferred solution(s) balancing environmental and business concerns? (ii) How to improve the understanding of the trade-offs between these two dimensions? We posit that a complete exploration of the efficient frontier and trade-offs between profitability and environmental impacts are particularly suitable to answer these two questions. In order to deal with the exponential number of basic efficient points in the frontier, we propose a formulation that performs in exponential time for the number of objective functions only. We illustrate our findings by designing a complex recycling logistics network in Germany.Eco-efficiency;Environmental impacts;Profitability;Recycling logistics network

From Closed-Loop to Sustainable Supply Chains: The WEEE case

The primary objective of closed-loop supply chains (CLSC) is to reap the maximum economic benefit from end-of-use products. Nevertheless, literature within this stream of research advocates that closing the loop helps to mitigate the undesirable footprint of supply chains. In this paper we assess the magnitude of such environmental gains for Electric and Electronic Equipments (EEE), based on a single environmental metric of Cumulative Energy Demand. We detail our analysis for the different phases of the CLSC, i.e. manufacturing, usage, transportation and end-of-life activities. According to our literature review, within the same group of EEE, results greatly vary. Furthermore, based on the environmental hot-spots, we propose extensions of the existing CLSC models to incorporate the CED.Closed-loop supply chains (CLSC);Cumulative energy demand;Electric and electronic equipments (EEE)

Mammographic and sonographic spectrum of non-puerperal mastitis

The goal of this study was to explore possible specific mammographic and sonographic features in women with non-puerperal mastitis (NPM), in order to make an accurate diagnosis and prevent unnecessary surgical procedures. From a group of 93 patients with NPM diagnosed between 1987 and 1992, the mammograms of 41, the sonograms and cytology of 47, and the histology of seven patients were retrospectively reviewed. Follow-up was performed on those without histology. In 20 of the 47 patients the inflammation was located subareolarly. In 50% of those with non-subareolar lesions, mammography showed a circumscribed lesion. Sonographically, all patients had an identifiable lesion either well or poorly defined. The majority of the lesions were cystic, but in 23 of 47 cases solid components were seen. Signs of infection in cystic lesions were observed in 25 of 47 cases. Posterior shadowing was not observed. During the follow-up period no breast malignancy was found. It is concluded that NPM has no specific mammographic or sonographic sign. Diagnosis should be made with additional diagnostic assessment, such as FNAB, which was diagnostic in all cases

From Closed-Loop to Sustainable Supply Chains: The WEEE case

The primary objective of closed-loop supply chains (CLSC) is to reap the maximum economic benefit from end-of-use products. Nevertheless, literature within this stream of research advocates that closing the loop helps to mitigate the undesirable footprint of supply chains. In this paper we assess the magnitude of such environmental gains for Electric and Electronic Equipments (EEE), based on a single environmental metric of Cumulative Energy Demand. We detail our analysis for the different phases of the CLSC, i.e. manufacturing, usage, transportation and end-of-life activities. According to our literature review, within the same group of EEE, results greatly vary. Furthermore, based on the environmental hot-spots, we propose extensions of the existing CLSC models to incorporate the CED

A Methodology for Assessing Eco-efficiency in Logistics Networks

Recent literature on sustainable logistics networks points to two important questions: (i) How to spot the preferred solution(s) balancing environmental and business concerns? (ii) How to improve the understanding of the trade-offs between these two dimensions? We posit that a complete exploration of the efficient frontier and trade-offs between profitability and environmental impacts are particularly suitable to answer these two questions. In order to deal with the exponential number of basic efficient points in the frontier, we propose a formulation that performs in exponential time for the number of objective functions only. We illustrate our findings by designing a complex recycling logistics network in Germany

Efficacy and safety of an intravenous monoclonal anti-HBs in chronic hepatitis B patients

Background Aims: In this study the safety and efficacy of a monoclonal anti-HBs, Tuvirumab (Mab), were investigated. Tuvirumab is a human monoclonal antibody recognizing the stable 'a'-determinant of the HBsAg. Methods: We included ten chronic hepatitis B patients: four received monotherapy, and six combination therapy with interferon alpha 2b. Results: Because the development of insoluble [HBsAg-HBsAb] complexes led to adverse events, the Mab dose had to be reduced in seven patients. In nine patients treatment was stopped prematurely because of lack of efficacy, i.e. neutralization of HBsAg in serum. However, temporary HBsAg levels were reduced by at least 50% in all patients; in three patients receiving combination therapy, background levels of HBsAg in serum were reached. A loss of serum HBV-DNA was seen in three patients in the combination group, followed by HBeAg seroconversion in two patients. Conclusions: We conclude that Mab was not effective in achieving primary efficacy as assessed by neutralization of circulating HBsAg. Whether a combination of Mab with an antiviral agent that reduces the HBsAg load - and therefore minimizes the risk of adverse events - may result in clinical efficacy should be investigated