Anxiety disorders in children with Williams syndrome, their mothers, and their siblings: Implications for the etiology of anxiety disorders

This study examines the prevalence of anxiety disorders in children with Williams syndrome (WS), their sibling closest in age, and their mothers as well as the predictors of anxiety in these groups. The prevalence of anxiety disorders was assessed and compared to that in the general population. Children with WS had a significantly higher prevalence of specific phobia, generalized anxiety disorder (GAD), and separation anxiety in comparison to children in the general population. While mothers had a higher prevalence of GAD than population controls, the excess was accounted for by mothers who had onset after the birth of their WS child. The siblings had rates similar to the general population. This pattern of findings suggests the presence of a gene in the WS region whose deletion predisposes to anxiety disorders. It is also worthwhile to investigate relations between genes deleted in WS and genes previously implicated in anxiety disorders

Comorbidity of autistic disorder in children and adolescents

Although considerable research has been done on various aspects of autism, information about the prevalence of coincident psychiatric disorders that may complicate this syndrome, is negligible. In this paper, we present preliminary data on the presentation of other psychiatric disorders in children and adolescents with autism. Out of an outpaticent sample of 68 autistic children and adolescents, 6 (9%) presented with an associated psychiatric disorder. Depression was the most common diagnosis. None of the patients was given a diagnosis of schizophrenia. Clinical and research implications of the findings are discussed. Bien qu'une recherche considérable ait été enterprise concenant les différents aspects de l'autisme, l'information sur la prévalence des troubles psychiatriques coïcidant et pouvant compliquer ce syndrome reste négligeable. Dans ce travail, nous présentons des faits préliminaires concernant les autres troubles psychiatriques chez les enfants et les adolescents avec autisme. Parmi un échantillon de 68 enfants et adolescents autistes vus en consultation: 6 (9%) présentaient un trouble psychiatrique associé La dépressio était le diagnostic le plus commun. Aucun des patients n'a eu un diagnostic de schizophrénie. Les implications de ces faits pour la clinique et la recherche sont discutées. Obwohl zu verschiedenen Aspekten des Autismus viel geforscht wurde, gibt es kaum Informationen zur koinzidentiellen Prävalenz von psychiatrischen Störungen, die das Syndrom komplizieren könne. In dieser Arbeit stellen wir vorläufige Daten über begleitende psychiatrische Störungen bei Kindern und Jugedlichen mit Autismus vor. Von 68 ambulant behandelten Kindern und Jugendlichen mit Autismus zeigten 9% eine assoziierte psychiatrische Störung. Depression war die häufigste Diagnose. Bei keinem der Patienten war die Diagnose Schizophrenie gestellt worden. Klinische und wissenschaftliche Implikationen dieser Befunde werden diskutiert.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/41754/1/787_2005_Article_BF02094180.pd

The catatonic dilemma expanded

Catatonia is a common syndrome that was first described in the literature by Karl Kahlbaum in 1874. The literature is still developing and remains unclear on many issues, especially classification, diagnosis, and pathophysiology. Clinicians caring for psychiatric patients with catatonic syndromes continue to face many dilemmas in diagnosis and treatment. We discuss many of the common problems encountered in the care of a catatonic patient, and discuss each problem with a review of the literature. Focus is on practical aspects of classification, epidemiology, differential diagnosis, treatment, medical comorbidity, cognition, emotion, prognosis, and areas for future research in catatonic syndromes