Circuito inferior da economia urbana: um estudo sobre o trabalho informal e a territorialidade das sacoleiras no município de Ituiutaba – MG

Trabalho de Conclusão de Curso (Graduação)O presente estudo teve como tema o trabalho informal das “sacoleiras” no município de Ituiutaba – MG, que foi relacionado à teoria dos dois circuitos da economia urbana, de Milton Santos. O objetivo geral deste trabalho é compreender as territorialidades das sacoleiras no município de Ituiutaba. A metodologia utilizada para dar início ao trabalho foi a revisão de literatura, garantindo embasamento científico. Como complemento da pesquisa, o método utilizado foi quantitativo e qualitativo; portanto, foi necessário aplicar uma entrevista semiestruturada a 27 sacoleiras, garantindo informações relevantes e solicitação de fotos via WhatsApp. Como resultado da pesquisa, observa-se a precariedade deste trabalho, relatada pelas sacoleiras no que se refere à oscilação da renda, ao fato de não ter férias e à necessidade de trabalhar muito, pois são responsáveis pela busca da mercadoria, publicidade, vendas, entrega e parte econômica. Por outro lado, muitas relatam os benefícios de serem sacoleiras, por administrarem seus horários, garantindo e conciliando com demais atividades diárias, desde a maternidade, cuidados com a casa, estudos e lazer

MEDIDAS ANTIDUMPING

RESUMO O intuito do presente texto é apresentar, de modo não exaustivo, a importância da intervenção estatal no domínio econômico, em específico sob o controle do comércio internacional, através de instrumentos de defesa comercial, como as medidas antidumping. Com a intensa expansão comercial entre os países, faz-se necessário que haja medidas inibidoras de práticas desleais, de tal modo que, seja possibilitado a todos uma base justa de concorrência, coibindo condutas que causem prejuízo aos empresários e trabalhadores que estejam alocados no país. As normativas que tratam sobre esse controle sofreram alterações relevantes, introduzidas principalmente através da Portaria SECEX nº 41/2013 e do Decreto nº 8.058/2013. [...

Manejo clínico na emergência para acidentes ofídicos: envenenamentos podem evoluir para choque anafilático? / Emergency clinical management for official accidents: can poisons evolve in anaphylactic shock?

Introdução: Acidentes ofídicos são quadros de envenenamento decorrentes da inoculação de uma peçonha através do aparelho inoculador de serpentes peçonhentas. Esses acidentes representam um problema de saúde pública mundial principalmente em países tropicais, visto à frequência que ocorrem e à morbimortalidade produzida. A atividade fisiopatológica decorrente de um acidente ofídico pode repercutir, em último grau, ao choque anafilático. Objetivo: Analisar relatos de casos de pacientes com intoxicação por animais peçonhentos, considerando quadros graves que evoluíram com choque anafilático, avaliando tanto manejo clínico, quanto gravidade e prognóstico desses pacientes, a fim de ampliar a compreensão sobre acidentes ofídicos na área da emergência. Métodos: Utilizou-se artigos indexados nos bancos de dados: SCIELO, PUBMED e LILICS com os seguintes descritores: Acidentes ofídicos; Animais peçonhentos; Urgência e emergência; Intoxicação; Choque anafilático; Manejo clínico. Resultados:  O reconhecimento do animal peçonhento é de fundamental grande importância a escolha do soro antiofídico correto. Além disso, todas as mordidas de crotalídeos requerem medidas de suporte e exames laboratorias (hemograma completo, coagulograma, mensuração dos produtos da degradação do fibrinogênio e fibrina séricos, exame de urina, mensuração de eletrólitos séricos, nitrogênio ureico do sangue e creatinina). Em relação ao veneno, as repercussões sistêmicas podem proceder através de três mecanismos: hemorragia, coagulação e proteólise. Com isso, a complicação mais grave é a anafilaxia decorrente de uma reação de hipersensibilidade imediata mediada por imunoglobulina E (IgE) aos antígenos do veneno. Conclusão: Acidentes ofídicos requerem um manejo clínico adequado e podem levar a complicações graves como choque anafilático

Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

IntroductionMannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, and may influence the synthesis of inflammatory cytokines. This study investigated the association of MBL2 gene polymorphisms with the plasma levels of MBL and inflammatory cytokines in COVID-19.MethodsBlood samples from 385 individuals (208 with acute COVID-19 and 117 post-COVID-19) were subjected to real-time PCR genotyping. Plasma measurements of MBL and cytokines were performed by enzyme-linked immunosorbent assay and flow cytometry, respectively.ResultsThe frequencies of the polymorphic MBL2 genotype (OO) and allele (O) were higher in patients with severe COVID-19 (p< 0.05). The polymorphic genotypes (AO and OO) were associated with lower MBL levels (p< 0.05). IL-6 and TNF-α were higher in patients with low MBL and severe COVID-19 (p< 0.05). No association of polymorphisms, MBL levels, or cytokine levels with long COVID was observed.DiscussionThe results suggest that, besides MBL2 polymorphisms promoting a reduction in MBL levels and therefore in its function, they may also contribute to the development of a more intense inflammatory process responsible for the severity of COVID-19

Mitochondrial variants of complex I genes associated with leprosy clinical subtypes

Abstract Leprosy is a chronic bacterial infection mainly caused by Mycobacterium leprae that primarily affects skin and peripheral nerves. Due to its ability to absorb carbon from the host cell, the bacillus became dependent on energy production, mainly through oxidative phosphorylation. In fact, variations in genes of Complex I of oxidative phosphorylation encoded by mtDNA have been associated with several diseases in humans, including bacterial infections, which are possible influencers in the host response to leprosy. Here, we investigated the presence of variants in the mtDNA genes encoding Complex I regarding leprosy, as well as the analysis of their pathogenicity in the studied cohort. We found an association of 74 mitochondrial variants with either of the polar forms, Pole T (Borderline Tuberculoid) or Pole L (Borderline Lepromatous and Lepromatous) of leprosy. Notably, six variants were exclusively found in both clinical poles of leprosy, including m.4158A>G and m.4248T>C in MT-ND1, m.13650C>A, m.13674T>C, m.12705C>T and m.13263A>G in MT-ND5, of which there are no previous reports in the global literature. Our observations reveal a substantial number of mutations among different groups of leprosy, highlighting a diverse range of consequences associated with mutations in genes across these groups. Furthermore, we suggest that the six specific variants exclusively identified in the case group could potentially play a crucial role in leprosy susceptibility and its clinical differentiation. These variants are believed to contribute to the instability and dysregulation of oxidative phosphorylation during the infection, further emphasizing their significance

The impact of physical disability on the quality of life of people with leprosy: a scoping review protocol

The proposed revision will be conducted in accordance with the JBI methodology for scope revisions. The P-C-C stragery Will be used to formulate the review question, with P corresponding to population/ participants, C to de concept to be investigated, and C to the context. P: patients with leprosy who have been treated or cured, irrespective of age or gender. C: the impact of physical disability on the quality of life of patients with leprosy. C: the development of physical disability in people with leprosy throughout the health care network. Accordingly, this review will consider studies on patients with leprosy, particularly those addressing quality of life or influential factors such as social exclusion and activity restriction owing to the development of physical disability. To this end, it included all types of sources published in Portuguese, English, and Spanish will be included without any date limit. The search strategy and the entire research process should adopt the methodology proposed by JBI for Scope Reviews. To identify articles on the topic, a limited initial search of PubMed and CINAHL was conducted. This allowed the development of the search strategy including keywords with the Boolean connectors AND and OR, namely, Leprosy”; “people with disabilities"; “disabled person”;”handicapped” and “quality of life”. Thereafter, the others databases: Cochrane, Web of Science, Lilacs, SciELO, Scopus, Embase, and VHL medical journals Will be included. After the search, all identified citations will be grouped and uploaded to Rayyan - the web and mobile app for systematic reviews and removed duplicates. After a pilot test, the full texts will be selected and exported to Mendeley Desktop, and Will be review by two independent reviewers to ensure that they meet the inclusion criteria

Nursing interventions in patients with chest pain with suspected acute coronary syndrome in the emergency room: a scoping review protocol

This review will be carried out according to the JBI methodology for scope review in order to map the interventions of the nursing team in emergency care for patients with chest pain with suspected acute coronary syndrome (ACS). The review question will be elaborated based on the Population-Concept-Context mnemonium (PCC) that corresponds to P - patients with chest pain complaint in adulthood (equal or greater than 18 years old) in the Emergency Room; C - nursing conduct in the emergency room for patients with chest pain with suspected acute coronary syndrome (ACS); C - Nursing interventions for patients with chest pain suspected of having ACS Coronary Syndrome (Infarction), in the context of urgency and emergency. Thus, the search strategy and the entire research process must adopt the methodology proposed by the JBI for scope reviews. Articles published in English, Spanish and Portuguese, with no stipulated date, will be considered. The databases selected for published articles were Latin American and Caribbean Health Sciences Literature (LILACS), Cochrane Library, Cumulative Index for Nursing and Allied Health Literature (CINAHL), MEDLINE via PubMed, Embase, Scopus and Web of Science. For the selection of unpublished articles and gray literature, OpenGray and Google Scholar were used. The keywords are Unstable Angina; Nursing care; Chest pain; Emergency Nursing; Acute Coronary Syndrome and the selected Boolean operator is "OR". The articles found will be managed through the Ryyan bibliography management platform and the duplicates removed

Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

National Council for Scientific and Technological Development (CNPQ #401235/2020-3); Fundação Amazônia de Amparo a Estudos e Pesquisa do Pará (FAPESPA #005/2020 and #006/2020), Secretaria de Estado de Ciência, Tecnologia e Educação Profissional e Tecnológica (#09/ 2021) and Universidade Federal do Pará (PAPQ/2022)Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Programa de Pós-Graduação em Virologia. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Programa de Pós-Graduação em Virologia. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Pesquisa Básica em Malária, Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Pesquisa Básica em Malária, Ananindeua, PA, Brasil / Federal University of Pará. Institute of Medical Sciences. School of Medicine. Belém, PA, Brazil.Belém Adventist Hospital. Belém, PA, Brazil.Belém Adventist Hospital. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Imunologia. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Imunologia. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Imunologia. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Programa de Pós-Graduação em Virologia. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Imunologia. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Ministério da Saúde. Secretaria de Ciência, Tecnologia, Inovação e Insumos Estratégicos. Instituto Evandro Chagas. Programa de Pós-Graduação em Virologia. Ananindeua, PA, Brasil / Ministério da Saúde. Secretaria de Vigilância em Saúde e Ambiente. Instituto Evandro Chagas. Laboratório de Imunologia. Ananindeua, PA, Brasil.University of the State of Pará. Center of Biological and Health Sciences. Belém, PA, Brazil.University of the State of Pará. Center of Biological and Health Sciences. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Laboratory of Genetics of Complex Diseases. Belém, PA, Brazil.Federal University of Pará. Institute of Biological Sciences. Laboratory of Virology. Belém, PA, Brazil / Federal University of Pará. Institute of Biological Sciences. Graduate Program in Biology of Infectious and Parasitic Agents. Belém, PA, Brazil.Introduction: Mannose-binding lectin (MBL) promotes opsonization, favoring phagocytosis and activation of the complement system in response to different microorganisms, and may influence the synthesis of inflammatory cytokines. This study investigated the association of MBL2 gene polymorphisms with the plasma levels of MBL and inflammatory cytokines in COVID-19. Methods: Blood samples from 385 individuals (208 with acute COVID-19 and 117 post-COVID-19) were subjected to real-time PCR genotyping. Plasma measurements of MBL and cytokines were performed by enzyme-linked immunosorbent assay and flow cytometry, respectively. Results: The frequencies of the polymorphic MBL2 genotype (OO) and allele (O) were higher in patients with severe COVID-19 (p< 0.05). The polymorphic genotypes (AO and OO) were associated with lower MBL levels (p< 0.05). IL-6 and TNF-α were higher in patients with low MBL and severe COVID-19 (p< 0.05). No association of polymorphisms, MBL levels, or cytokine levels with long COVID was observed. Discussion: The results suggest that, besides MBL2 polymorphisms promoting a reduction in MBL levels and therefore in its function, they may also contribute to the development of a more intense inflammatory process responsible for the severity of COVID-19

NEOTROPICAL CARNIVORES: a data set on carnivore distribution in the Neotropics

Mammalian carnivores are considered a key group in maintaining ecological health and can indicate potential ecological integrity in landscapes where they occur. Carnivores also hold high conservation value and their habitat requirements can guide management and conservation plans. The order Carnivora has 84 species from 8 families in the Neotropical region: Canidae; Felidae; Mephitidae; Mustelidae; Otariidae; Phocidae; Procyonidae; and Ursidae. Herein, we include published and unpublished data on native terrestrial Neotropical carnivores (Canidae; Felidae; Mephitidae; Mustelidae; Procyonidae; and Ursidae). NEOTROPICAL CARNIVORES is a publicly available data set that includes 99,605 data entries from 35,511 unique georeferenced coordinates. Detection/non-detection and quantitative data were obtained from 1818 to 2018 by researchers, governmental agencies, non-governmental organizations, and private consultants. Data were collected using several methods including camera trapping, museum collections, roadkill, line transect, and opportunistic records. Literature (peer-reviewed and grey literature) from Portuguese, Spanish and English were incorporated in this compilation. Most of the data set consists of detection data entries (n = 79,343; 79.7%) but also includes non-detection data (n = 20,262; 20.3%). Of those, 43.3% also include count data (n = 43,151). The information available in NEOTROPICAL CARNIVORES will contribute to macroecological, ecological, and conservation questions in multiple spatio-temporal perspectives. As carnivores play key roles in trophic interactions, a better understanding of their distribution and habitat requirements are essential to establish conservation management plans and safeguard the future ecological health of Neotropical ecosystems. Our data paper, combined with other large-scale data sets, has great potential to clarify species distribution and related ecological processes within the Neotropics. There are no copyright restrictions and no restriction for using data from this data paper, as long as the data paper is cited as the source of the information used. We also request that users inform us of how they intend to use the data