In vitro modelling of the physiological and diseased female reproductive system

The maladies affecting the female reproductive tract (FRT) range from infections to endometriosis to carcinomas. In vitro models of the FRT play an increasingly important role in both basic and translational research, since the anatomy and physiology of the FRT of humans and other primates differ significantly from most of the commonly used animal models, including rodents. Using organoid culture to study the FRT has overcome the longstanding hurdle of maintaining epithelial phenotype in culture. Both ECM-derived and engineered materials have proved critical for maintaining a physiological phenotype of FRT cells in vitro by providing the requisite 3D environment, ligands, and architecture. Advanced materials have also enabled the systematic study of factors contributing to the invasive metastatic processes. Meanwhile, microphysiological devices make it possible to incorporate physical signals such as flow and cyclic exposure to hormones. Going forward, advanced materials compatible with hormones and optimised to support FRT-derived cells' long-term growth, will play a key role in addressing the diverse array of FRT pathologies and lead to impactful new treatments that support the improvement of women's health

Open government data: Areas and directions for research

The concept of open data itself is strongly associated with innovative capacity and transformative power (Davies, Perini, & Alonso, 2013). It is increasingly recognized that proactively opening public data can create considerable benefits for several stakeholders, such as firms and individuals interested in the development of value added digital services or mobile applications, by combining various types of Open Government Data (OGD), and possibly other private data. On the other hand, OGD also empowers scientists, journalists and active citizens who want to understand various public issues and policies through advanced data processing and production of analytics (Janssen, 2011a; Zuiderwijk, Helbig, Gil-García, & Janssen, 2014).Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Information and Communication Technolog