Features of disease course of some forms of herpesvirus infection

Among the many factors that directly affect the immune system, infections caused by the herpes virus deserve special attention. In recent years, there has been an increase in the number of patients suffering from chronic recurrent herpesvirus infections, which in many cases are accompanied by severe general malaise and a number of therapeutic complaints. Today about 80-95% of the population is infected with Epstein-Barr virus EBV. Primary infection of EBV leads to lifelong persistence of the pathogen with possible periodic reactivation under the action of various immunosuppressive factors, which leads to chronic forms of the disease. EBV can cause chronic manifest and erased forms of the disease, running on the type of chronic mononucleosis. Thus, the study of the nature of clinical and laboratory changes in patients with chronic EBV infection and the peculiarities of the disease is an urgent problem of our time. The aim of this work was to study the features of the course of chronic EBV infection. We performed a comprehensive clinical and laboratory examination of 128 patients with chronic EBV infection (reactivation period). The diagnosis of chronic EBV infection was established on the basis of medical history, complaints, the presence of specific antibodies to EBV antigens and the detection of virus DNA in the blood. Studies of clinical blood tests of patients with chronic EBV infection and the control group showed differences. Thus, in patients with chronic EBV infection, a significantly elevated ESR level was found - 12.6 ± 1.8 versus 4.5 ± 1.1 inthe control group (p <0.05). The levels of erythrocytes, hemoglobin and platelets did not differ significantly from the control group. In patients with chronic EBV infection, there was a decrease in the level of leukocytes (5.13 ± 0.22) x 109/ l against (6.20 ± 1.8) x 109/l in the control group (p> 0.05), but these changes did not go beyond the norms established for healthy people. Analysis of the leukocyte formula revealed the presence of patients with chronic WEB infection with a significant increase in the relative content of lymphocytes - 42.50 ± 2.0% against 33.70 ± 2.68% (p <0.05) and monocytes - 11.15 ± 0.9% vs. 3.0 ± 0.6% (p <0.05), which was the basis for confirming the presence of a chronic infectious process. In general, 94.8% of patients with chronic EBV infection had lymphocytosis and 82.5% had monocytosis. The relative number of neutrophils in patients with chronic WEB infection averaged 45.35 ± 4.1% against 61.7 ± 3.8% in the control group (p <0.05); the relative number of eosinophils and basophils was within normal limits. When studying the absolute number of lymphocytes and monocytes in patients with chronic EBV infection, there was a tendency to increase them and their level was on average (2.13 ± 0.7) x 109/ l and (0.51 ± 0.08) x 109/ l against (2.39 ± 0.7) x 109/ l and (0.47 ± 0.08) x 109/ l in the control group (p> 0.05). The absolute number of neutrophils in patients with chronic WEB infection was significantly lower than in the control group and was 2.70 x 109/ l versus 4.21 x 109/ l (p <0.05). The study of the absolute number of eosinophils and basophils in patients with chronic EBV infection did not reveal statistically significant differences compared with the control group. Thus, according to the results of our study, we found that patients with chronic EBV infection among the clinical manifestations were most often chronic tonsillitis, chronic fatigue syndrome and peripheral lymphadenopathy. Analysis of the results of laboratory studies revealed a significant increase in ESR, relative lymphocytes and monocytes, as well as a decrease in absolute and relative neutrophils, compared with the control group of patients, indicating a shift in white blood cell count, characteristic of the viral etiology of the disease what associated with the EBV.DOI: 10.5281/zenodo.403896

Дистанційне навчання: нові виклики

Сорокіна, Г. М. Дистанційне навчання: нові виклики // Проблеми впровадження дистанційного навчання в освітньому процесі закладів вищої освіти та можливі шляхи їх вирішення : тези доп. Міжвуз. наук.-метод. семінару (м. Харків, 26 січ. 2021 р.). - Харків, 2021. - С. 73-75.Пандемія та локдаун в березні 2020 року - час, який став етапом на шляху набуття досвіду викладання іноземних мов в умовах дистанційного навчання. Вивчення іноземної мови дистанційно - нова реальність як для викладачів, так і для студентів. Дистанційні форми навчання універсальні, вони дозволяють використовувати будь-які прийоми і методи навчання. Система освіти, безумовно, в подальшому буде характеризуватися стрімким розвитком і впровадженням технологій дистанційної освіти.The pandemic and lockdown in March 2020 was a time that has become a stage on the way of gaining experience in teaching foreign languages in the environment of distance education. Learning a foreign language remotely is a new reality for both teachers and students. Distance learning forms are universal, which means that they allow you to use any teaching techniques and methods. The education system surely will be characterized by the rapid development and implementation of distance education technologies in the future.Пандемия и локдаун в марте 2020 года – время, ставшее этапом на пути приобретения опыта преподавания иностранных языков в условиях дистанционного обучения. Изучение иностранного языка дистанционно - новая реальность как для преподавателей, так и для студентов. Дистанционные формы обучения универсальны, они позволяют использовать любые приемы и методы обучения. Система образования, безусловно, в дальнейшем будет характеризоваться стремительным развитием и внедрением технологий дистанционного образования

Полікультурне виховання співробітників правоохоронних органів

Сорокіна, Г. М. Полікультурне виховання співробітників правоохоронних органів / Галина Миколаївна Сорокіна // Психологічні та педагогічні проблеми професійної освіти та патріотичного виховання персоналу системи МВС України : матеріали наук.-практ. конф. (м. Харків, 8 квіт. 2016 р.) / МВС України, Харків. нац. ун-т внутр. справ. – Харків, 2016. – С. 165-167.Зазначено, що співробітник поліції є членом полікультурного середовища, тому полікультурна освіта і формування професійної полікультурної компетенції відіграють важливу роль в рамках підготовки майбутніх правоохоронців.It is noted that a police officer is a member of a multicultural environment, therefore multicultural education and the formation of professional multicultural competence play an important role in the training of future law enforcement officers.Отмечено, что сотрудник полиции является членом поликультурной среды, поэтому поликультурное образование и формирование профессиональной поликультурной компетенции играют немаловажную роль в рамках подготовки будущих правоохранителей

Подолати страх розмовляти іноземною мовою

Сорокіна, Г. М. Подолати страх розмовляти іноземною мовою / Г. М. Сорокіна // Від традицій до інновацій в навчанні іноземних мов у закладах вищої освіти : тези доп. міжвуз. наук.-метод. семінару (м. Харків, 25 січ. 2022 р.) / Нац. акад. Нац. гвардії України. – Харків, 2022. – С. 93-95.Багато людей відчувають страх, коли виникає потреба говорити іноземною мовою. Причини страху перед спілкуванням іноземною мовою різні. Процесу комунікації найчастіше заважають причини психологічного характеру. Виявлення цих причин та знаходження шляхів їх усунення – завдання викладача іноземної мови.Many people are afraid when they need to speak a foreign language. The reasons for fear of communicating in a foreign language are different. The process of communication is often hindered by psychological reasons. Identifying these reasons and finding the ways to resolve them is the task of a foreign language teacher.Многие люди испытывают страх, когда возникает необходимость говорить на иностранном языке. Причины страха перед общением на иностранном языке разные. Процессу коммуникации чаще всего препятствуют причины психологического характера. Выявление этих причин и нахождение путей их устранения - задача преподавателя иностранного языка

Dynamics and Radiation of Young Type-Ia Supernova Remnants: Important Physical Processes

We examine and analyze the physical processes that should be taken into account when modeling young type-Ia SNRs, with ages of several hundred years. It is shown, that energy losses in the metal-rich ejecta can be essential for remnants already at this stage of evolution. The influence of electron thermal conduction and the rate of the energy exchange between electrons and ions on the temperature distribution and the X-radiation from such remnants is studied. The data for Tycho SNR from the XMM-Newton X-ray telescope have been employed for the comparison of calculations with observations.Comment: 19 pages, 8 figure

The role of the Barents Sea in the Arctic climate system

Present global warming is amplified in the Arctic and accompanied by unprecedented sea ice decline. Located along the main pathway of Atlantic Water entering the Arctic, the Barents Sea is the site of coupled feedback processes that are important for creating variability in the entire Arctic air-ice-ocean system. As warm Atlantic Water flows through the Barents Sea, it loses heat to the Arctic atmosphere. Warm periods, like today, are associated with high northward heat transport, reduced Arctic sea ice cover, and high surface air temperatures. The cooling of the Atlantic inflow creates dense water sinking to great depths in the Arctic Basins, and ~60% of the Arctic Ocean carbon uptake is removed from the carbon-saturated surface this way. Recently, anomalously large ocean heat transport has reduced sea ice formation in the Barents Sea during winter. The missing Barents Sea winter ice makes up a large part of observed winter Arctic sea ice loss, and in 2050, the Barents Sea is projected to be largely ice free throughout the year, with 4°C summer warming in the formerly ice-covered areas. The heating of the Barents atmosphere plays an important role both in “Arctic amplification” and the Arctic heat budget. The heating also perturbs the large-scale circulation through expansion of the Siberian High northward, with a possible link to recent continental wintertime cooling. Large air-ice-ocean variability is evident in proxy records of past climate conditions, suggesting that the Barents Sea has had an important role in Northern Hemisphere climate for, at least, the last 2500 years

Regeneration limit of classical Shannon capacity

Since Shannon derived the seminal formula for the capacity of the additive linear white Gaussian noise channel, it has commonly been interpreted as the ultimate limit of error-free information transmission rate. However, the capacity above the corresponding linear channel limit can be achieved when noise is suppressed using nonlinear elements; that is, the regenerative function not available in linear systems. Regeneration is a fundamental concept that extends from biology to optical communications. All-optical regeneration of coherent signal has attracted particular attention. Surprisingly, the quantitative impact of regeneration on the Shannon capacity has remained unstudied. Here we propose a new method of designing regenerative transmission systems with capacity that is higher than the corresponding linear channel, and illustrate it by proposing application of the Fourier transform for efficient regeneration of multilevel multidimensional signals. The regenerative Shannon limit -the upper bound of regeneration efficiency -is derived

Is sea-ice-driven Eurasian cooling too weak in models?

This is the author accepted manuscript. The final version is available from Nature Research via the DOI in this recordData availability: The FACTS and CESM simulations are freely available and were obtained from the following repositories: https://www.esrl.noaa.gov/psd/repository/facts and https://www.cesm.ucar.edu/projects/community-projects/LENS

Thermonuclear Burning Regimes and the Use of SNe Ia in Cosmology

The calculations of the light curves of thermonuclear supernovae are carried out by a method of multi-group radiation hydrodynamics. The effects of spectral lines and expansion opacity are taken into account. The predictions for UBVI fluxes are given. The values of rise time for B and V bands found in our calculations are in good agreement with the observed values. We explain why our results for the rise time have more solid physical justification than those obtained by other authors. It is shown that small variations in the chemical composition of the ejecta, produced in the explosions with different regimes of nuclear burning, can influence drastically the light curve decline in the B band and, to a lesser extent, in the V band. We argue that recent results on positive cosmological constant Lambda, found from the high redshift supernova observations, could be wrong in the case of possible variations of the preferred mode of nuclear burning in the earlier Universe.Comment: 20 pages, 5 figures, presented at the conference "Astronomy at the Eve of the New Century", Puschino, May 17-22, 1999. A few references and a table added, typos correcte

Pharmacoinformatic investigation of medicinal plants from East Africa

Medicinal plants have widely been used in the traditional treatment of ailments and have been proven effective. Their contribution still holds an important place in modern drug discovery due to their chemical, and biological diversities. However, the poor documentation of traditional medicine, in developing African countries for instance, can lead to the loss of knowledge related to such practices. In this study, we present the Eastern Africa Natural Products Database (EANPDB) containing the structural and bioactivity information of 1870 unique molecules isolated from about 300 source species from the Eastern African region. This represents the largest collection of natural products (NPs) from this geographical region, covering literature data of the period from 1962 to 2019. The computed physicochemical properties and toxicity profiles of each compound have been included. A comparative analysis of some physico-chemical properties like molecular weight, H-bond donor/acceptor, logP(o/w), etc. as well scaffold diversity analysis has been carried out with other published NP databases. EANPDB was combined with the previously published Northern African Natural Products Database (NANPDB), to form a merger African Natural Products Database (ANPDB), containing similar to 6500 unique molecules isolated from about 1000 source species (freely available at http://african-compounds.org). As a case study, latrunculins A and B isolated from the spongeNegombata magnifica(Podospongiidae) with previously reported antitumour activities, were identified via substructure searching as molecules to be explored as putative binders of histone deacetylases (HDACs)