157 research outputs found

    Indexing the White House Statements Regarding Snowden and NSA: A Content Analysis of U.S. Elite Newspapers’ Opinion Pieces

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    The current study aims to advance knowledge about indexing and elite debates by examining and comparing coverage of a complex issue in the official government statements and opinion sections of two elite American news organizations. More specifically, this research examines whether or not The New York Times and The Wall Street Journal used any news frames promoted by The White House regarding the former NSA contactor Edward Snowden and his whistleblowing attempts. Results of the textual analysis of The White House Statements and selected opinion pieces indicate that indexing did not occur and a variety of opinion took place. Listed results fall in the theoretical realm of the indexing hypothesis. The study demonstrated that opinion journalism serves an important role in facilitating debates around salient issues and informing the public about those debates

    Olivier Vargin. Regards sur l’art contemporain russe (1990-2010)

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    Très peu de livres sur l’art contemporain russe abordent ses évolutions et ses tendances actuelles, ses problématiques brûlantes et sa relation aux anciens blocs Est et Ouest. Parmi les ouvrages qui tentent de pallier ce manque, celui d’Olivier Vargin est bienvenu et tombe à point nommé. Le terme « regards », présent dans le titre, est censé justifier la subjectivité de l’approche —une stratégie somme toute légitime— mais il reste à déterminer sur quels faits se fondent ces réflexions subject..

    Olivier Vargin. Regards sur l’art contemporain russe (1990-2010)

    Get PDF
    Très peu de livres sur l’art contemporain russe abordent ses évolutions et ses tendances actuelles, ses problématiques brûlantes et sa relation aux anciens blocs Est et Ouest. Parmi les ouvrages qui tentent de pallier ce manque, celui d’Olivier Vargin est bienvenu et tombe à point nommé. Le terme « regards », présent dans le titre, est censé justifier la subjectivité de l’approche —une stratégie somme toute légitime— mais il reste à déterminer sur quels faits se fondent ces réflexions subject..

    Modernity as it could have been

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    “Eastern Europe doesn’t exist any longer” : the opening statement of the curators’ text for the exhibition catalogue Les Promesses du passé : une histoire discontinue de l’art dans l’ex-Europe de l’Est lucidly formulates the current state of affairs of the subject matter in question. Indeed, after twenty years and dozens of exhibitions addressing, reflecting on, deconstructing, critically investigating and conceptually reformulating the “former East” of Europe, its communist past and post-com..

    La Modernité telle qu’elle aurait pu être

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    « L’Europe de l’Est n’existe plus » : cette phrase ouvre le catalogue de l’exposition Les Promesses du passé : une histoire discontinue de l’art dans l’ex-Europe de l’Est et formule clairement la situation actuelle du sujet. Après vingt ans et des dizaines d’expositions qui abordent, se penchent sur, déconstruisent, examinent de façon critique puis reformulent conceptuellement l’« ancien Est » de l’Europe, son passé communiste et son présent post-communiste, la conclusion de l’Europe entière ..

    Functional analysis of human mutations in homeodomain transcription factor PITX3

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    <p>Abstract</p> <p>Background</p> <p>The homeodomain-containing transcription factor <it>PITX3 </it>was shown to be essential for normal eye development in vertebrates. Human patients with point mutations in <it>PITX3 </it>demonstrate congenital cataracts along with anterior segment defects in some cases when one allele is affected and microphthalmia with brain malformations when both copies are mutated. The functional consequences of these human mutations remain unknown.</p> <p>Results</p> <p>We studied the PITX3 mutant proteins S13N and G219fs to determine the type and severity of functional defects. Our results demonstrate alterations in DNA-binding profiles and/or transactivation activities and suggest a partial loss-of-function in both mutants with the G219fs form being more severely affected. No anomalies in cellular distribution and no dominant-negative effects were discovered for these mutants. Interestingly, the impairment of the G219fs activity varied between different ocular cell lines.</p> <p>Conclusion</p> <p>The G219fs mutation was found in multiple families affected with congenital cataracts along with anterior segment malformations in many members. Our data suggest that the presence/severity of anterior segment defects in families affected with G219fs may be determined by secondary factors that are expressed in the developing anterior segment structures and may modify the effect(s) of this mutation. The S13N mutant showed only minor alteration of transactivation ability and DNA binding pattern and may represent a rare polymorphism in the <it>PITX3 </it>gene. A possible contribution of this mutation to human disease needs to be further investigated.</p
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