Large cell anaplastic lypmhoma versus Hodgkin's disease – difficulties in the diagnosis

AbstractDuring the last 5 years in the Polish Children's Leukemia/Lymphoma Study Group (7 centers) 241 children with Hodgkin's Disease and 14 children with Large Cell Anaplastic Lymphoma were treated.In 5 of them we had problems with differential diagnosis.Immunohistochemical tests:–CD30 positive, CD15 positive, LCA negative allowed us to change the diagnosis from Large Cell Anaplastic Lymphoma to Hodgkin's Disease (one child) and–CD30 positive, CD15 negative from Hodgkin's Disease to Large Cell Anaplastic Lymphoma (four children).All children achieved remission after changing the protocol of chemotherapy

Large cell anaplastic lypmhoma versus Hodgkin's disease – difficulties in the diagnosis

During the last 5 years in the Polish Children's Leukemia/Lymphoma Study Group (7 centers) 241 children with Hodgkin's Disease and 14 children with Large Cell Anaplastic Lymphoma were treated.In 5 of them we had problems with differential diagnosis.Immunohistochemical tests:–CD30 positive, CD15 positive, LCA negative allowed us to change the diagnosis from Large Cell Anaplastic Lymphoma to Hodgkin's Disease (one child) and–CD30 positive, CD15 negative from Hodgkin's Disease to Large Cell Anaplastic Lymphoma (four children).All children achieved remission after changing the protocol of chemotherapy