Promoting the Self-Determination of Students with Severe Cognitive Disabilities

This literature review explores five published articles focused on the promotion of self- determination of students with severe cognitive disabilities. The purpose of this literature review is to better understand the details of the interventions designed to support students with the most severe cognitive disabilities. Within this framework, data was collected to examine participants, settings, implementers, and results. All five studies reported positive outcomes for all students in the promotion of self-determination

Dual Therapy with Cidofovir and Mirtazapine for Progressive Multifocal Leukoencephalopathy in a Sarcoidosis Patient

Background: Progressive multifocal leukoencephalopathy (PML) is a demyelinating central nervous system disease caused by JC virus (JCV) reactivation in immunocompromised patients. The disease course of PML is often progressive, fatal and at present, there are few reports on successful treatment outcomes. Case Report: A 45-year-old man with systemic sarcoidosis presented with rapidly progressive dementia and right hemiparesis. The patient was diagnosed with PML as confirmed via brain biopsy and JCV PCR. With a combination treatment of cidofovir and mirtazapine, there was significant improvement of neurological symptoms without measurable functional deficit. Conclusion: This case suggests that dual therapy with cidofovir and mirtazapine might be an effective treatment option in PML patients with sarcoidosis

Diagnostic accuracy of a three-protein signature in women with suspicious breast lesions: a multicenter prospective trial

Background Mammography screening has been proven to detect breast cancer at an early stage and reduce mortality; however, it has low accuracy in young women or women with dense breasts. Blood-based diagnostic tools may overcome the limitations of mammography. This study assessed the diagnostic performance of a three-protein signature in patients with suspicious breast lesions. Findings This trial (MAST; KCT0004847) was a prospective multicenter observational trial. Three-protein signature values were obtained using serum and plasma from women with suspicious lesions for breast malignancy before tumor biopsy. Additionally, blood samples from women who underwent clear or benign mammography were collected for the assays. Among 642 participants, the sensitivity, specificity, and overall accuracy values of the three-protein signature were 74.4%, 66.9%, and 70.6%, respectively, and the concordance index was 0.698 (95% CI 0.656, 0.739). The diagnostic performance was not affected by the demographic features, clinicopathologic characteristics, and co-morbidities of the participants. Conclusions The present trial showed an accuracy of 70.6% for the three-protein signature. Considering the value of blood-based biomarkers for the early detection of breast malignancies, further evaluation of this proteomic assay is warranted in larger, population-level trials. This Multi-protein Assessment using Serum to deTermine breast lesion malignancy (MAST) was registered at the Clinical Research Information Service of Korea with the identification number of KCT0004847 (https://cris.nih.go.kr).This study was supported by the Bertis Inc. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication

The Relationship between Korean Parents’ Smartphone Addiction and That of Their Children: The Mediating Effects of Children’s Depression and Social Withdrawal

With the number of smartphone users growing around the world, children are using smartphones from an increasingly early age. Consequently, a significant number of children are being exposed to the risk of smartphone addiction, which is emerging as a serious social problem. Smartphone addiction can negatively impact children’s physical, cognitive, and social development. Previous studies have demonstrated that parental smartphone addiction influences that of their children. Therefore, this study explores the relationship between parental smartphone addiction and children’s smartphone addiction and the mediating effects of children’s depression and social withdrawal. Data are drawn from National Youth Policy Institute’s 2018 Korean Children and Youth Panel Survey. Respondents comprise 2011 fourth-grade elementary school students and their parents. Data were analyzed using SPSS version 21.0 and AMOS 21.0 software. Results show that the relationship between parental smartphone addiction and that of their children has a significantly positive mediating effect on children’s social withdrawal, but no such effect on children’s depression and there were no serial effects of children’s depression and social withdrawal. Consequently, educational programs that control parents’ smartphone usage, improve the parent–child relationship, and engender social sensitivity should be developed to reduce and prevent smartphone addiction among children

The Relationship between the Frequency of Breakfast Consumption, Conversation with Parents, and Somatic Symptoms in Children: A Three-Wave Latent Growth Model

Breakfast consumption is essential for children to generate energy for the day. Parents play an important role in children’s breakfast habits and spending time with parents during breakfast greatly influences children’s emotional development. Therefore, this study investigated the relationship between the frequency of children’s breakfast consumption, time spent in conversation with parents, and children’s somatic symptoms. Data were obtained from the Korea Children and Youth Panel Survey 2018 and were initially collected from fourth-grade elementary school students and followed up for three years. SPSS 21.0 and AMOS 21.0 software were used for data analysis. Multivariate latent growth modeling was applied to analyze the effect of the breakfast consumption frequency on children’s somatic symptoms and the mediating effect of parent–child conversation time on this relationship. Consequently, as children’s frequency of breakfast consumption increased, their somatic symptoms decreased. Furthermore, parent–child conversation time mediated the relationship between these two variables. Therefore, students, parents, and teachers should be educated about the importance of having breakfast and communicating with parents for students’ emotional health

Complete chloroplast genome of Acer tegmentosum and phylogenetic analysis

The aim of the present study was to sequence and analyze the complete plastid genome (i.e. plastome) of Acer tegmentosum Maxim. The plastome of A. tegmentosum was 156,435 bp in length and included both large (86,265 bp) and small (18,102 bp) single-copy regions, which were separated by a pair of identical inverted repeats (26,034 bp). The plastome contained 77 unique protein-coding genes, 30 tRNA genes, and four rRNA genes. In addition, the gene order and organization of the A. tegmentosum plastome were consistent with those of plastomes from other members of the Sapindaceae, and the overall GC content of the plastome was 37.8%. A phylogenetic tree that was based on 76 protein-coding genes demonstrated a sister relationship within genus Acer

Complete chloroplast genome of Corylopsis spicata and phylogenetic analysis

The complete plastid genome of Corylopsis spicata was sequenced and analyzed in this study. It was found to be 159,507 bp and consisted of a large (88,243 bp) and small (18,716 bp) single-copy regions, separated by a pair of identical inverted repeats (26,274 bp). The GC content of the whole genome was 36.9%, and there were 85 unique protein-coding genes, 37 tRNA, and eight rRNA. The gene order and organization were consistent with those of other complete plastid genomes from the Hamamelidaceae. A phylogenetic tree was constructed based on 76 protein-coding genes that demonstrated a sister relationship within the genus Corylopsis

The complete chloroplast genome of Torreya nucifera (Taxaceae) and phylogenetic analysis

Torreya nucifera (L.) Siebold & Zucc. (Taxaceae) is a tertiary relict tree species with a distribution that is limited to South Korea and Japan. In the present study, the complete chloroplast (cp) genome of T. nucifera was sequenced and analyzed. The genome was 136,985 bp in length and contained 118 genes, including 82 protein-coding genes, 33 tRNA genes, and 4 rRNA genes. Fifteen of the genes contained a single intron, whereas ycf3 contained two introns and there were no inverted repeat sequences in the genome. Phylogenetic analysis supported the monophyly of Torreya species within the Taxaceae and T. nucifera was closely related to its congener T. grandis