Probable Case of Neuroleptic Malignant Syndrome Following Administration of Antituberculotic Drugs in a Chlorpromazine-Treated Patient

Neuroleptic malignant syndrome (NMS), a potentially fatal adverse reaction to neuroleptics, is known to occur more often in the initial stage of antipsychotic treatment. We describe a patient with chronic schizophrenia who, in a few days after the addition of antituberculotic drugs to his antipsychotic regimen, developed probable NMS without pyrexia. We reasoned that rifampin, a strong hepatic enzyme inducer, decreased the plasma chlorpromazine concentration of the patient, with the result of cholinergic hyperactivity and finally, the symptoms of NMS. Therefore, physicians should be aware of drug interactions and the likelihood of NMS, and consider antipsychotic dose adjustment when prescribing drugs that may influence pharmacokinetic properties of antipsychotics in a patient with schizophrenia receiving long-term antipsychotic treatment

REMOTE SENSING OF WAVE DIRECTIONALITY BY TWO-DIMENSIONAL DIRECTIONAL WAVELETS: PART 1. THE DETECTION TOOLS OF DIRECTIONALITY IN SIGNALS

This paper presents the results of a study investigating methods of wave directionality based on wavelet transform. In part 1 of this paper, the theoretical background and characteristics of directional wavelet were discussed. Morlet wavelet and Cauchy wavelet were examined to test their efficiency in detection of directionality in signals. These wavelets were tested on numerical images which were considered to describe the basic characteristics of directionality of ocean waves

State Estimation Filtering using Recent Finite Measurements and Inputs for Active Suspension System with Temporary Uncertainties

In this paper, the finite memory structure(FMS) filter using most recent finite measured outputs and control inputs is applied for the state estimation filtering of automotive suspension systems to verify intrinsic robustness of FMS filter. Firstly, the single-corner model for the automotive suspension system and its state-space model are described. Secondly, FMS as well as infinite memory structure(IMS) filters are briefly introduced and represented by the summation form. Thirdly, a couple of temporary uncertainties, model uncertainty and unknown input, are discussed. Finally, extensive computer simulations are performed for both nominal system and temporarily uncertain system. It is shown that the FMS filter can be better than the IMS filter for both temporary uncertainties. In addition, the FMS filter can be shown to be comparable to the IMS filter after the effects of a couple of temporary uncertainties have completely disappeared

Altered Eye-Movement Patterns During Text Reading in Obsessive–Compulsive Disorder and Internet Gaming Disorder

Obsessive-compulsive disorder (OCD) and internet gaming disorder (IGD), which are similar in that both involve repetitive behaviors and related with cognitive dysfunctions, frequently begin in early adolescence, which is a critical period for learning. Although the deterioration in cognitive functioning caused by these conditions may have adverse effects on information processing, such as text reading, there has been no comprehensive research on the objective indicators of altered reading patterns in these patients. Therefore, we evaluated eye-movement patterns during text reading in patients with OCD or IGD. In total, 20 patients with OCD, 28 patients with IGD and 24 healthy controls (HCs) participated in the reading task using an eye tracker. We compared the fixation durations (FDs), saccade amplitudes and eye-movement regressions of the three groups during reading. We explored relationships between the parameters reflecting altered reading patterns and those reflecting the severity of clinical symptoms. The average FDs and forward saccade amplitudes did not differ significantly among the groups. There were more eye-movement regressions in patients with OCD than in patients with IGD and HCs. No correlation was found between altered eye-movement patterns during reading and the severity of clinical symptoms in any of the patient groups. The significantly increased number of regressions (NRs) in the OCD group during reading may reflect these patients’ difficulties with inferential information processing, whereas the reading pattern in the IGD group is relatively intact. These findings suggest that patients with OCD and patients with IGD have different eye-movement patterns during reading reflecting distinct cognitive impairments in the two patient groups

REMOTE SENSING OF WAVE DIRECTIONALITY BY TWO-DIMENSIONAL DIRECTIONAL WAVELETS : PART 2. APPLICATIONS TO THE NUMERICAL AND FIELD DATA

This paper presents the results of a study investigating methods of interpretation of wave directionality based on wavelet transform. In part 1 of this paper, the tools to be used in detection of wave directionality, i. e., the Morlet and Cauchy wavelets, were described. This paper presents the application results of the directional wavelet to numerically generated images and video images taken in laboratory wave flume, river, and sea. The results showed that directional wavelet transform can be an efficient tool in detecting wave directionality with extremely low effort and cost when it is compared to traditional practices in use