2,283 research outputs found
Fuzzy Weight Cluster-Based Routing Algorithm for Wireless Sensor Networks
Cluster-based protocol is a kind of important routing in wireless sensor networks. However, due to the uneven distribution of cluster heads in classical clustering algorithm, some nodes may run out of energy too early, which is not suitable for large-scale wireless sensor networks. In this paper, a distributed clustering algorithm based on fuzzy weighted attributes is put forward to ensure both energy efficiency and extensibility. On the premise of a comprehensive consideration of all attributes, the corresponding weight of each parameter is assigned by using the direct method of fuzzy engineering theory. Then, each node works out property value. These property values will be mapped to the time axis and be triggered by a timer to broadcast cluster headers. At the same time, the radio coverage method is adopted, in order to avoid collisions and to ensure the symmetrical distribution of cluster heads. The aggregated data are forwarded to the sink node in the form of multihop. The simulation results demonstrate that clustering algorithm based on fuzzy weighted attributes has a longer life expectancy and better extensibility than LEACH-like algorithms
Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer
<p>Abstract</p> <p>Background</p> <p>Tumor cells need large energy and nucleic acids to proliferate and grow. For most of their energy needs, cancer cells depend more on glycolysis. For most of their nucleic acids needs, cancer cells depend more on the nonoxidative pathway of the pentose phosphate pathway. Transketolase(TKT) is a crucial enzyme in the nonoxidative pathway of the PPP.</p> <p>Methods</p> <p>The real-time quantity PCR was used to determine the expression of transketolase gene family in uterine cervix cancer. Transketolase activity of cell was determined by using enzyme-linked method. Cell proliferation was detected by using MTT.</p> <p>Results</p> <p>The TKTL1 mRNA was specifically over-expressed in uterine cervix cancer cells(HeLa cell line) compare with normal human endocervical epithelial cells(End1/E6E7 cell line)(P < 0.05), whereas the expression of TKT and transketolase-like gene 2(TKTL2) have no significant differences between the two cell lines(P > 0.05). Moreover, we found that total transketolase activity was significantly reduced, and cell proliferation was remarkably inhibited after anti-TKTL1 siRNA treatment in HeLa cells. The total transketolase activity and cell proliferation have no significant differences after anti-TKTL1 siRNA treatment in End1/E6E7 cells.</p> <p>Conclusion</p> <p>These results indicate that TKTL1 plays an important role in total transketolase activity and cells proliferation in uterine cervix cancer.</p
Acoustic Vortex in Waveguide with Chiral Gradient Sawtooth Metasurface
The acoustic vortex states with spiral phase dislocation that can carry
orbital angular moment (OAM) have aroused many research interests in recent
years. The mainstream methods of generating acoustic vortex are based on
Huygens-Fresnel principle to modulate the wavefront to create spatial spiral
phase dislocation. In this work, we propose an entirely new scenario to
generate acoustic vortex in a waveguide with chiral gradient sawtooth
metasurface. The physical mechanism of our method is to lift the degenerate
dipole eigenmodes through the scattering effect of the chiral surface
structure, and then the superposition of them will generate both and order
vortices in place. Compared to the existing methods of acoustic vortex
production, our design has many merits, such as easy to manufacture and
control, the working frequency is broadband, sign of vortex order can be
readily flipped. Both the full-wave simulations and experimental measurements
validate the existence of the acoustic vortices. The torque effect of the
acoustic vortices is also successfully performed by rotating a foam disk as a
practical application. Our work opens up a new route for generating acoustic
vortex and could have potential significances in microfluidics, acoustic
tweezers and ultrasonic communication, etc
Coulomb effects on the formation of proton halo nuclei
The exotic structures in the 2s_{1/2} states of five pairs of mirror nuclei
^{17}O-^{17}F, ^{26}Na-^{26}P, ^{27}Mg-^{27}P, ^{28}Al-^{28}P and
^{29}Si-^{29}P are investigated with the relativistic mean-field (RMF) theory
and the single-particle model (SPM) to explore the role of the Coulomb effects
on the proton halo formation. The present RMF calculations show that the exotic
structure of the valence proton is more obvious than that of the valence
neutron of its mirror nucleus, the difference of exotic size between each
mirror nuclei becomes smaller with the increase of mass number A of the mirror
nuclei and the ratios of the valence proton and valence neutron
root-mean-square (RMS) radius to the matter radius in each pair of mirror
nuclei all decrease linearly with the increase of A. In order to interpret
these results, we analyze two opposite effects of Coulomb interaction on the
exotic structure formation with SPM and find that the contribution of the
energy level shift is more important than that of the Coulomb barrier for light
nuclei. However, the hindrance of the Coulomb barrier becomes more obvious with
the increase of A. When A is larger than 34, Coulomb effects on the exotic
structure formation will almost become zero because its two effects counteract
with each other.Comment: 9 pages, 6 figures. One colum
PAN: Pulse Ansatz on NISQ Machines
Variational quantum algorithms (VQAs) have demonstrated great potentials in
the NISQ era. In the workflow of VQA, the parameters of ansatz are iteratively
updated to approximate the desired quantum states. We have seen various efforts
to draft better ansatz with less gates. In quantum computers, the gate ansatz
will eventually be transformed into control signals such as microwave pulses on
transmons. And the control pulses need elaborate calibration to minimize the
errors such as over-rotation and under-rotation. In the case of VQAs, this
procedure will introduce redundancy, but the variational properties of VQAs can
naturally handle problems of over-rotation and under-rotation by updating the
amplitude and frequency parameters. Therefore, we propose PAN, a native-pulse
ansatz generator framework for VQAs. We generate native-pulse ansatz with
trainable parameters for amplitudes and frequencies. In our proposed PAN, we
are tuning parametric pulses, which are natively supported on NISQ computers.
Considering that parameter-shift rules do not hold for native-pulse ansatz, we
need to deploy non-gradient optimizers. To constrain the number of parameters
sent to the optimizer, we adopt a progressive way to generate our native-pulse
ansatz. Experiments are conducted on both simulators and quantum devices to
validate our methods. When adopted on NISQ machines, PAN obtained improved the
performance with decreased latency by an average of 86%. PAN is able to achieve
99.336% and 96.482% accuracy for VQE tasks on H2 and HeH+ respectively, even
with considerable noises in NISQ machines.Comment: 13 pages, 13 figure
Interface induced high temperature superconductivity in single unit-cell FeSe films on SrTiO3
Searching for superconducting materials with high transition temperature (TC)
is one of the most exciting and challenging fields in physics and materials
science. Although superconductivity has been discovered for more than 100
years, the copper oxides are so far the only materials with TC above 77 K, the
liquid nitrogen boiling point. Here we report an interface engineering method
for dramatically raising the TC of superconducting films. We find that one
unit-cell (UC) thick films of FeSe grown on SrTiO3 (STO) substrates by
molecular beam epitaxy (MBE) show signatures of superconducting transition
above 50 K by transport measurement. A superconducting gap as large as 20 meV
of the 1 UC films observed by scanning tunneling microcopy (STM) suggests that
the superconductivity could occur above 77 K. The occurrence of
superconductivity is further supported by the presence of superconducting
vortices under magnetic field. Our work not only demonstrates a powerful way
for finding new superconductors and for raising TC, but also provides a
well-defined platform for systematic study of the mechanism of unconventional
superconductivity by using different superconducting materials and substrates
Comprehensive Analysis of the Association Between the rs1138272 Polymorphism of the GSTP1 Gene and Cancer Susceptibility
Background: We obtained conflicting results regarding the relationship between the genetic role of the rs1138272 C/T polymorphism of the GSTP1 (Glutathione S-Transferase pi) gene and the risk of various cancers.Methods: Using the presently available data, a meta-analysis was conducted to comprehensively evaluate the genetic relationship between the GSTP1 rs1138272 polymorphism and cancer susceptibility.Results: A total of 43 studies including 15,688 cases and 17,143 controls were recruited into our quantitative synthesis. In the overall population, we observed an increased risk of overall cancer cases, compared with unrelated controls, in the genetic models of allele T vs. allele C (P-association = 0.007, OR = 1.17), carrier T vs. carrier C (P-association = 0.035, OR = 1.11), TT vs. CC (P-association = 0.002, OR = 1.45), TT vs. CC+CT (P-association = 0.009, OR = 1.42), and CT+TT vs. CC (P-association = 0.027, OR = 1.13). We detected similar positive results within the Asian population. Additionally, there was a significant increase in the incidence of cancer for Africans under all genetic models (all P-association < 0.05, OR > 1). When targeting the Caucasian population, we detected a positive association with the TT vs. CC and TT vs. CC+CT models in the “Colorectal cancer” (P-association < 0.05, OR < 1) and “Head and neck cancer” (P-association < 0.05, OR > 1) subgroups. For the “Lung cancer” subgroup, we observed a slightly increased risk in Caucasians under the models of allele T vs. allele C, carrier T vs. carrier C, CT vs. CC, and CT+TT vs. CC (P-association < 0.05, OR > 1).Conclusion: The TT genotype of the GSTP1 rs1138272 polymorphism is likely related to the susceptibility to overall cancer in the Asian and African populations and, specifically, “Colorectal” and “Head and neck” cancers in the Caucasian population. In addition, the CT genotype of the GSTP1 rs1138272 polymorphism may be linked to the risk of lung cancer in Caucasians. Additional evidence is required to confirm this conclusion
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