Solitonic pulse generation for inter-satellite optical wireless communication

In this paper, a system consist of series of microring resonators (MRRs) and an add/drop filter are used to generate a large bandwidth signal as localized multi wavelength, applicable for inter-satellite optical wireless communication. This technique uses the Kerr nonlinear type of light in the MRR to generate multi wavelength for desired application in inter-satellite communication. Results show that multi soliton wavelength, ranged from 900 nm to 1228 with FWHM and FSR of 35 pm and 500 pm can be generated respectively

Plasma PCSK9 level affects passively LAMP-2 expression; an evidence of transcription network

Free cholesterol accumulation in lysosomes is related to highly glycosylated membrane-protein functions, endogenous cholesterol synthesis and, LDL influx. The LAMP-1 and LAMP-2 are two lysosome proteins involved in cholesterol transport. The study aim was to investigate the associations between LAMP-2 expression level, LAMP-2/LAMP-1 expression ratio, blood PCSK9 protein and LDL-C values. One hundred twenty six healthy subjects were selected during a medical interview. The biochemical parameters were measured using routine laboratory techniques. The plasma PCSK9 level was identified by ELISA method. The LAMP-1/LAMP-2 expression levels were estimated by Real time qPCR technique. The PCSK9 and LAMP-2 expression networks were designed with Cytoscape software and, were enriched using transcription factor databases. Linear correlations were observed between PCSK9 and LDL-C levels (r = 0.34; p = 0.002) and, TC/HDL-C ratio (r = 0.35; p = 0.001). The LAMP-2 expression level and LAMP-2/LAMP-1 expression ratio were inversely related to LDL-C values (p = 0.02). The transcription factors were compartmented on the merged network and were strictly controlled the PCSK9 expression. The results suggested that the decreased LDL influx due to the increase of plasma PCSK9 level attenuates the LAMP-2 gene expression level. Furthermore, the merged network supported our findings that the LAMP-2 expression is not in relation to transcription factors involved with PCSK9 expression. © 2016 Elsevier Inc

The Second-Harmonic Generation in a Dissipative and Dispersion Layered Structure

The conversion efficiency of the fundamental radiation to the second harmonic wave is investigated under different linear absorptions of the interactive waves in a layered structure. We have considered that both the fundamental and the generated second harmonic waves are arbitrarily absorbed in each layer without any relation between them that has been considered on the previous studies. The layers of the structure are assumed to have different linear and nonlinear optical absorptions

The second-harmonic generation in a dissipative and dispersion layered structure

Conversion efficiency of second-harmonic generation (SHG) in a multicrystal structure arrangement, under linearly absorption of interacting waves was analytically investigated. Different linear absorption and nonlinear interaction coefficients were considered for both of the fundamental and the second harmonic waves in cascade layers. The intensity-constant approximation on fundamental wave radiation was applied in calculations. Behavior of conversion efficiency with interaction coherence length of fundamental wave, phase miss-matching and ratio of linear absorption coefficients were graphically illustrated. The results are shown that in multicrystal structure scheme, the conversion efficiency can be tuned by the interaction coherent length and it is possible to compensate the phase differences induced in the previous layers. The phase compensation between the layers is the physical reason of efficiency improvement

Profiling delirium progression in elderly patients via continuous-time markov multi-state transition models

none11Poor recognition of delirium among hospitalized elderlies is a typical challenge for health care professionals. Considering methodological insufficiency for assessing time-varying diseases, a continuous-time Markov multi-state transition model (CTMMTM) was used to investigate delirium evolution in elderly patients. This is a longitudinal observational study performed in September 2016 in an Italian hospital. Change of delirium states was modeled according to the 4AT score. A Cox model (CM) and a CTMMTM were used for identifying factors affecting delirium onset both with a two-state and three-state model. In this study, 78 patients were enrolled and evaluated for 5 days. Both the CM and the CTMMTM show that urine catheter (UC), aging, drugs, and invasive devices (ID) are risk factors for delirium onset. The CTMMTM model shows that transition from nodelirium/cognitive impairment to delirium was associated with aging (HR = 1.14; 95%CI, 1.05, 1.23) and neuroleptics (HR = 4.3; 1.57, 11.77), dopaminergic drugs (HR = 3.89; 1.2, 12.6), UC (HR = 2.92; 1.09, 7.79) and ID (HR = 1.67; 103, 2.71). These results are confirmed by the multivariable model. Aging, ID, antibiotics, drugs affecting the central nervous system, and absence of moving ability are identified as the significant predictors of delirium. Additionally, it seems that modeling with CTMMTM may show associations that are not directly detectable with the traditional CM.noneOcagli H.; Azzolina D.; Soltanmohammadi R.; Aliyari R.; Bottigliengo D.; Acar A.S.; Stivanello L.; Degan M.; Baldi I.; Lorenzoni G.; Gregori D.Ocagli, H.; Azzolina, D.; Soltanmohammadi, R.; Aliyari, R.; Bottigliengo, D.; Acar, A. S.; Stivanello, L.; Degan, M.; Baldi, I.; Lorenzoni, G.; Gregori, D