Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles

Objectives: To evaluate the ability of manganese perovskite nanoparticles (lanthanum-strontium manganite) to heat the tumor tissue in vivo under action of external alternating magnetic field. Materials and Methods: The magnetic fluid on the basis of nanoparticles of perovskite manganite was tested in the heating experiments using of alternating magnetic field of frequency 300 kHz and amplitude 7.7 kA/m. Guerin carcinoma was transplanted into the muscle of rat. Magnetic fluid was injected intramuscularly or intratumorally. Temperature was measured by copper-constantan thermocouple. Results: Temperature of magnetic fluid was increased by 56 °C for 10 min of alternating magnetic field action. Administration of magnetic fluid into the muscle followed by alternating magnetic field resulted in the elevation of muscle temperature by 8 °C after 30 min post injection. Temperature of the tumor injected with magnetic fluid and treated by alternating magnetic field was increased by 13.6 °C on the 30 min of combined influence. Conclusion: In vivo study with rat tissue has demonstrated that magnetic fluid of manganite perovskite injected in the tumor increases the tumor temperature under an alternating magnetic field. Obtained results emphasize that magnetic fluid of manganite perovskite can be considered as effective inducer of tumor hyperthermia

Nanohyperthermia of malignant tumors.i. lanthanum-strontium manganite magnetic fluid as potential inducer of tumor hyperthermia

Objectives: To synthesize magnetic particles of lanthanum-strontium manganite, prepare the magnetic fluid (MF), evaluate the generation of heat by particles and determine their common toxiсity. Methods: Nanoparticles based on the solid solutions of lanthanum-strontium manganite (La1-xSrxMnO3) have been synthesized by a sol-gel method. Conventional methods of experimental oncology were used. Results: Nanoparticles of ferromagnetic materials on the basis of solid solutions of lanthanum strontium manganite by sol-gel method were synthesized. It was shown the possibility to regulate the aggregate form of particles that are formed during the synthesis. Magnetic fluid based on the synthesized nanoparticles and water solutions of agarose have been produced. It was shown the possibility to heat this magnetic fluid up to 42–45 °С in externally applied alternating magnetic field (AMF) operated at 100–400 kHz. It was determined that under long-term influence of AMF nanofluid is heated up to temperature which is not over that of magnetic phase transition. It was detected that magnetic powder as well as fluid have not displayed acute toxicity or side effects (intraperitoneal or intratumoral administration) in animals either intact or with transplanted tumors. Conclusions: Possibility of synthesized magnetic fluid to generate heat in externally applied AMF as well as lack of side effects allow to consider its as a potential mean for tumor hyperthermia (HT)

Magnetic Properties and AC Losses in AFe 2

Nanosized particles of AFe2O4 (A = Mn, Co, Ni, or Zn) spinel ferrites were synthesized by coprecipitation from nonaqueous solutions using nitrate salts as starting reagents. The particles were characterized by X-ray diffraction, transmission electron microscopy, and magnetic measurements. Quasistatic magnetic measurements show superparamagnetic behavior with blocking temperature below room temperature for cobalt, nickel, and zinc spinel ferrite nanoparticles. Characteristic magnetic parameters of the particles including average magnetic moment of an individual nanoparticle and blocking temperature have been determined. The specific loss power which is released on the exposure of an ensemble of synthesized particles to a magnetic field is calculated and measured experimentally. It is shown that among all nanoferrites under study, the ZnFe2O4 nanoparticles demonstrate the highest heating efficiency in AC magnetic fields. The key parameters responsible for the heating efficiency in AC magnetic field have been determined. The directions to enhance the SLP value have been outlined

Synthesis, Properties and Applications of some Magnetic Oxide Based Nanoparticles and Films

The work highlights peculiar features of synthesis and summarizes important properties of nanoparticles and films based on two types of oxide magnets: with spinel and perovskite-type structures. The attention is drawn to the differences in the processes underlying the formation of crystalline phase in the materials of each group. It is shown that for the spinels, the formation of weakly agglomerated crystalline nanoparticles can occur in the process of synthesis, but for the perovskite-like magnets, the formation of crystalline nanoparticles requires additional high-temperature treatment. It is demonstrated that synthesized nanoparticles and films may find wide practical applications, particularly as the heat mediators in hyperthermia treatment therapy, as components of left-handed media, ferroelectric-ferromagnetic layered structures and composite microwave resonators. They also may be used as integral parts of composite structures, which possess magnetic-field-controlled properties and display giant magnetocaloric effect

Synthesis and properties MFe2O4 (M = Fe, Co) nanoparticles and core–shell structures

International audienc

Synthesis, Properties and Applications of some Magnetic Oxide Based Nanoparticles and Films

The work highlights peculiar features of synthesis and summarizes important properties of nanoparticles and films based on two types of oxide magnets: with spinel and perovskite-type structures. The attention is drawn to the differences in the processes underlying the formation of crystalline phase in the materials of each group. It is shown that for the spinels, the formation of weakly agglomerated crystalline nanoparticles can occur in the process of synthesis, but for the perovskite-like magnets, the formation of crystalline nanoparticles requires additional high-temperature treatment. It is demonstrated that synthesized nanoparticles and films may find wide practical applications, particularly as the heat mediators in hyperthermia treatment therapy, as components of left-handed media, ferroelectric-ferromagnetic layered structures and composite microwave resonators. They also may be used as integral parts of composite structures, which possess magnetic-field-controlled properties and display giant magnetocaloric effect

Synthesis of Iron Oxide Nanoparticles by Different Methods and Study of their Properties

International audienc

Magnetic Properties and AC Losses in AFe2O4 (A = Mn, Co, Ni, Zn) Nanoparticles Synthesized from Nonaqueous Solution

Nanosized particles of AFe2O4 (A = Mn, Co, Ni, or Zn) spinel ferrites were synthesized by coprecipitation from nonaqueous solutions using nitrate salts as starting reagents. The particles were characterized by X-ray diffraction, transmission electron microscopy, and magnetic measurements. Quasistatic magnetic measurements show superparamagnetic behavior with blocking temperature below room temperature for cobalt, nickel, and zinc spinel ferrite nanoparticles. Characteristic magnetic parameters of the particles including average magnetic moment of an individual nanoparticle and blocking temperature have been determined. The specific loss power which is released on the exposure of an ensemble of synthesized particles to a magnetic field is calculated and measured experimentally. It is shown that among all nanoferrites under study, the ZnFe2O4 nanoparticles demonstrate the highest heating efficiency in AC magnetic fields. The key parameters responsible for the heating efficiency in AC magnetic field have been determined. The directions to enhance the SLP value have been outlined