Molecular gas in nearby low-luminosity QSO host galaxies

This paper addresses the global molecular gas properties of a representative sample of galaxies hosting low-luminosity quasistellar objects. An abundant supply of gas is necessary to fuel both the active galactic nucleus and any circum-nuclear starburst activity of QSOs. We selected a sample of nearby low-luminosity QSO host galaxies that is free of infrared excess biases. All objects are drawn from the Hamburg-ESO survey for bright UV-excess QSOs, have DEC>-30 degrees and redshifts that do not exceed z=0.06. The IRAM 30m telescope was used to measure the CO(1-0) and CO(2-1) transition in parallel. 27 out of 39 galaxies in the sample have been detected. The molecular gas masses of the detected sources range from 0.4E9 M_sun to 9.7E9 M_sun. We can confirm that the majority of galaxies hosting low-luminosity QSOs are rich in molecular gas. The properties of galaxies hosting brighter type I AGN and circumnuclear starformation regions differ from the properties of galaxies with fainter central regions. The overall supply of molecular gas and the spread of the line width distribution is larger. When comparing the far-infrared with the CO luminosities, the distribution can be separated into two different power-laws: one describing the lower activity Seyfert I population and the second describing the luminous QSO population. The separation in the L_FIR/L'_CO behavior may be explainable with differing degrees of compactness of the emission regions. We provide a simple model to describe the two power-laws. The sample studied in this paper is located in a transition region between the two populations

Disk, merger, or outflow ? Molecular gas kinematics in two powerful obscured QSOs at z>3.4

We report on the detection of bright CO(4-3) line emission in two powerful, obscured quasars discovered in the SWIRE survey, SW022513 and SW022550 at z>3.4. We analyze the line strength and profile to determine the gas mass, dynamical mass and the gas dynamics for both galaxies. In SW022513 we may have found the first evidence for a molecular, AGN-driven wind in the early Universe. The line profile in SW022513 is broad (FWHM = 1000 km/s) and blueshifted by -200 km/s relative to systemic (where the systemic velocity is estimated from the narrow components of ionized gas lines, as is commonly done for AGN at low and high redshifts). SW022550 has a more regular, double-peaked profile, which is marginally spatially resolved in our data, consistent with either a merger or an extended disk. The molecular gas masses, 4x10^10 Msun, are large and account for <30% of the stellar mass, making these obscured QSOs as gas rich as other powerful CO emitting galaxies at high redshift, i.e., submillimeter galaxies. Our sources exhibit relatively lower star-formation efficiencies compared to other dusty, powerful starburst galaxies at high redshift. We speculate that this could be a consequence of the AGN perturbing the molecular gas.Comment: Accepted for publication in A&

Hubble Space Telescope Wide Field Planetary Camera 2 observations of hyperluminous infrared galaxies

We present Hubble Space Telescope Wide Field Planetary Camera 2 I-band imaging for a sample of nine hyperluminous infrared galaxies (HLIRGs) spanning a redshift range 0.45 &lt; z &lt; 1.34. Three of the sample have morphologies showing evidence for interactions and six are quasi-stellar objects (QSOs). Host galaxies in the QSOs are detected reliably out to z ∼ 0.8. The detected QSO host galaxies have an elliptical morphology with scalelengths spanning 6.5 &lt; re (kpc) &lt; 88 and absolute k-corrected magnitudes spanning −24.5 &lt; MI &lt; −25.2. There is no clear correlation between the infrared (IR) power source and the optical morphology. None of the sources in the sample, including F15307+3252, shows any evidence for gravitational lensing. We infer that the IR luminosities are thus real. Based on these results, and previous studies of HLIRGs, we conclude that this class of object is broadly consistent with being a simple extrapolation of the ULIRG population to higher luminosities; ULIRGs being mainly violently interacting systems powered by starbursts and/or active galactic nuclei. Only a small number of sources, the infrared luminosities of which exceed 1013 L⊙, are intrinsically less luminous objects that have been boosted by gravitational lensing

The challenges faced in the design, conduct and analysis of surgical randomised controlled trials

Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the evaluation of surgical interventions. Surgical trials are difficult to successfully undertake and pose particular practical and methodological challenges. However, RCTs have played a role in the assessment of surgical innovations and there is scope and need for greater use. This article will consider the design, conduct and analysis of an RCT of a surgical intervention. The issues will be reviewed under three headings: the timing of the evaluation, defining the research question and trial design issues. Recommendations on the conduct of future surgical RCTs are made. Collaboration between research and surgical communities is needed to address the distinct issues raised by the assessmentof surgical interventions and enable the conduct of appropriate and well-designed trials.The Health Services Research Unit is funded by the Scottish Government Health DirectoratesPeer reviewedPublisher PD

Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden

Bladder cancers are a leading cause of death from malignancy. Molecular markers might predict disease progression and behaviour more accurately than the available prognostic factors. Here we use whole-genome sequencing to identify somatic mutations and chromosomal changes in 14 bladder cancers of different grades and stages. As well as detecting the known bladder cancer driver mutations, we report the identification of recurrent protein-inactivating mutations in CDKN1A and FAT1. The former are not mutually exclusive with TP53 mutations or MDM2 amplification, showing that CDKN1A dysfunction is not simply an alternative mechanism for p53 pathway inactivation. We find strong positive associations between higher tumour stage/grade and greater clonal diversity, the number of somatic mutations and the burden of copy number changes. In principle, the identification of sub-clones with greater diversity and/or mutation burden within early-stage or low-grade tumours could identify lesions with a high risk of invasive progression

B-Type Natriuretic Peptide and Cardiac Troponin I Are Associated With Adverse Outcomes in Stable Kidney Transplant Recipients

Approximately 200,000 kidney transplant recipients are living in the US; they are at increased risk for cardiovascular and other adverse outcomes. Biomarkers predicting these outcomes are needed. Using specimens collected during the FAVORIT (Folic Acid for Vascular Outcome Reduction In Transplantation) trial, we determined whether plasma levels of B-type natriuretic peptide (BNP) and cardiac troponin I are associated with adverse outcomes in stable kidney transplant recipients

On the detection and refinement of transcription factor binding sites using ChIP-Seq data

Coupling chromatin immunoprecipitation (ChIP) with recently developed massively parallel sequencing technologies has enabled genome-wide detection of protein–DNA interactions with unprecedented sensitivity and specificity. This new technology, ChIP-Seq, presents opportunities for in-depth analysis of transcription regulation. In this study, we explore the value of using ChIP-Seq data to better detect and refine transcription factor binding sites (TFBS). We introduce a novel computational algorithm named Hybrid Motif Sampler (HMS), specifically designed for TFBS motif discovery in ChIP-Seq data. We propose a Bayesian model that incorporates sequencing depth information to aid motif identification. Our model also allows intra-motif dependency to describe more accurately the underlying motif pattern. Our algorithm combines stochastic sampling and deterministic ‘greedy’ search steps into a novel hybrid iterative scheme. This combination accelerates the computation process. Simulation studies demonstrate favorable performance of HMS compared to other existing methods. When applying HMS to real ChIP-Seq datasets, we find that (i) the accuracy of existing TFBS motif patterns can be significantly improved; and (ii) there is significant intra-motif dependency inside all the TFBS motifs we tested; modeling these dependencies further improves the accuracy of these TFBS motif patterns. These findings may offer new biological insights into the mechanisms of transcription factor regulation

Potential climatic transitions with profound impact on Europe

We discuss potential transitions of six climatic subsystems with large-scale impact on Europe, sometimes denoted as tipping elements. These are the ice sheets on Greenland and West Antarctica, the Atlantic thermohaline circulation, Arctic sea ice, Alpine glaciers and northern hemisphere stratospheric ozone. Each system is represented by co-authors actively publishing in the corresponding field. For each subsystem we summarize the mechanism of a potential transition in a warmer climate along with its impact on Europe and assess the likelihood for such a transition based on published scientific literature. As a summary, the ‘tipping’ potential for each system is provided as a function of global mean temperature increase which required some subjective interpretation of scientific facts by the authors and should be considered as a snapshot of our current understanding. <br/