Interventions and instruments to promote sustainable land use in Europe

Since the first examples of human settlements, land has been subject to transformations. With the industrial revolution and in particular after the Second World War, land transformation has become more intense in terms of overexploitation of natural resources. Only recently, however, have policy and decision makers acknowledged the importance of land as a finite resource. Sustainable development has increasingly become the subject of many studies and a reason for debate, leading to different lines of thought among the various disciplines. This has led to the design and implementation of a great number of sustainable land use practices in many European cities and regions. In fact, it seems that sustainability of land use depends both on the socio-economic processes that trigger spatial development and the effectiveness of the instruments that regulate these processes (Solly et al., 2020). The need for a more sustainable and eco-compatible approach, and the European objective to achieve zero net land take 2050 (Science for Environment Policy, 2016), have been one of the reasons why ESPON launched the pan-European research project SUPER – Sustainable Urbanization and land-use in the European Regions. The project examines, on the one hand, the nature and the structure of urbanization processes and, on the other, it seeks to analyze the degree of success of interventions and instruments aiming at a more sustainable use of land. This contribution presents the results of the project by focusing especially on the content of the SUPER “Guide to Sustainable Urbanisation and Land Use” (Cotella et al., 2020). Thanks to the exploration of more than two hundred examples of urbanization interventions gathered all over Europe, the guide suggests a set of policy recommendations for policy and decision makers in order to address land use in a more sustainable perspective. According to the different objectives and contextual needs, policy and decision makers should focus more on: (i) which intervention (i.e. densification, regeneration, containment, governance and sectoral policies) and (ii) which instrument, should be used (i.e. visions and strategies, rules and legal devices, land use regulations, programmes and projects)

ESPON SUPER – Sustainable Urbanisation and land-use Practices in European Regions. A GUIDE TO SUSTAINABLE URBANISATION AND LAND-USE

Guides help you do things. You turn to them when you need to find out how to solve a problem. They are a form of knowledge transfer, written by experts in a way that is accessible and helpful to a wide audience. This guide was written by the researchers engaged in the ESPON 2020 applied research project on Sustainable Urbanisation and Land-Use Practices in European Regions (SUPER). It aims to help people and institutions engaged with land-use management at various levels across Europe to promote sustainable urbanisation in their territories. Overall, the guide offers information, ideas and perspectives to help decision-makers and policymakers to proactively contribute to more equal, balanced, and sustainable territorial development. The decision to convert land to a different use influences our quality of life and that of future generations, and, as this Guide shows, a large toolbox of interventions exists that can help alter prevailing land-use practices. Choosing among them is a tough decision, and implementation may require strong political commitment and bold leadership. We hope that this Guide provides the inspiration to accept this challenge

The Design and Development of the SMEX-Lite Power System

This paper describes the design and development of a 250W orbit average electrical power system electronic Power Node and software for use in Low Earth Orbit missions. The mass of the Power Node is 3.6 Kg (8 lb.). The dimensions of the Power Node are 30cm x 26cm x 7.9cm (11 in. x 10.25 in x 3.1 in.) The design was realized using software, Field Programmable Gate Array (FPGA) digital logic and surface mount technology. The design is generic enough to reduce the non-recurring engineering for different mission configurations. The Power Node charges one to five, low cost, 22-cell 4 AH D-cell battery packs independently. The battery charging algorithms are executed in the power software to reduce the mass and size of the power electronic. The Power Node implements a peak-power tracking algorithm using an innovative hardware/software approach. The power software task is hosted on the spacecraft processor. The power software task generates a MIL-STD-1553 command packet to update the Power Node control settings. The settings for the battery voltage and current limits, as well as minimum solar array voltage used to implement peak power tracking are contained in this packet. Several advanced topologies are used in the Power Node. These include synchronous rectification in the bus regulators, average current control in the battery chargers and quasi-resonant converters for the Field Effect Transistor (FET) transistor drive electronics. Lastly, the main bus regulator uses a feed-forward topology with the PWM implemented in an FPGA

A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis

AbstractThe mechanism during apoptosis by which cytochrome c is rapidly and completely released in the absence of mitochondrial swelling is uncertain. Here, we show that two distinct pathways are involved. One mediates release of cytochrome c across the outer mitochondrial membrane, and another, characterized in this study, is responsible for the redistribution of cytochrome c stored in intramitochondrial cristae. We have found that the “BH3-only” molecule tBID induces a striking remodeling of mitochondrial structure with mobilization of the cytochrome c stores (∼85%) in cristae. This reorganization does not require tBID's BH3 domain and is independent of BAK, but is inhibited by CsA. During this process, individual cristae become fused and the junctions between the cristae and the intermembrane space are opened

A study on the effects of cognitive overloading and distractions on human movement during robot-assisted dressing

For robots that can provide physical assistance, maintaining synchronicity of the robot and human movement is a precursor for interaction safety. Existing research on collaborative HRI does not consider how synchronicity can be affected if humans are subjected to cognitive overloading and distractions during close physical interaction. Cognitive neuroscience has shown that unexpected events during interactions not only affect action cognition but also human motor control Gentsch et al. (Cognition, 2016, 146, 81–89). If the robot is to safely adapt its trajectory to distracted human motion, quantitative changes in the human movement should be evaluated. The main contribution of this study is the analysis and quantification of disrupted human movement during a physical collaborative task that involves robot-assisted dressing. Quantifying disrupted movement is the first step in maintaining the synchronicity of the human-robot interaction. The human movement data collected from a series of experiments where participants are subjected to cognitive loading and distractions during the human-robot interaction, are projected in a 2-D latent space that efficiently represents the high-dimensionality and non-linearity of the data. The quantitative data analysis is supported by a qualitative study of user experience, using the NASA Task Load Index to measure perceived workload, and the PeRDITA questionnaire to represent the human psychological state during these interactions. In addition, we present an experimental methodology to collect interaction data in this type of human-robot collaboration that provides realism, experimental rigour and high fidelity of the human-robot interaction in the scenarios

The regulation of miRNAs by reconstituted high-density lipoproteins in diabetes-impaired angiogenesis

Diabetic vascular complications are associated with impaired ischaemia-driven angiogenesis. We recently found that reconstituted high-density lipoproteins (rHDL) rescue diabetes-impaired angiogenesis. microRNAs (miRNAs) regulate angiogenesis and are transported within HDL to sites of injury/repair. The role of miRNAs in the rescue of diabetes-impaired angiogenesis by rHDL is unknown. Using a miRNA array, we found that rHDL inhibits hsa-miR-181c-5p expression in vitro and using a hsa-miR-181c-5p mimic and antimiR identify a novel anti-angiogenic role for miR-181c-5p. miRNA expression was tracked over time post-hindlimb ischaemic induction in diabetic mice. Early post-ischaemia when angiogenesis is important, rHDL suppressed hindlimb mmu-miR-181c-5p. mmu-miR-181c-5p was not detected in the plasma or within HDL, suggesting rHDL specifically targets mmu-miR-181c-5p at the ischaemic site. Three known angiogenic miRNAs (mmu-miR-223-3p, mmu-miR-27b-3p, mmu-miR-92a-3p) were elevated in the HDL fraction of diabetic rHDL-infused mice early post-ischaemia. This was accompanied by a decrease in plasma levels. Only mmu-miR-223-3p levels were elevated in the hindlimb 3 days post-ischaemia, indicating that rHDL regulates mmu-miR-223-3p in a time-dependent and site-specific manner. The early regulation of miRNAs, particularly miR-181c-5p, may underpin the rescue of diabetes-impaired angiogenesis by rHDL and has implications for the treatment of diabetes-related vascular complications

The STAR-X X-Ray Telescope Assembly (XTA)

The Survey and Time-domain Astrophysical Research eXplorer (STAR-X) science goals are to discover what powers the most violent explosions in the Universe, understand how black holes grow across cosmic time and mass scale, and measure how structure formation heats the majority of baryons in the Universe. To achieve these goals, STAR-X requires a powerful X-ray telescope with a large field of view, large collecting area, and excellent point spread function. The STAR-X instrument, the X-Ray Telescope Assembly (XTA), meets these requirements using a powerful X-ray mirror technology based on precision-polished single crystal silicon and a mature CCD detector technology. The XTA is composed of three major subsystems: an X-ray Mirror Assembly (MA) of high resolution, lightweight mirror segments fabricated out of single crystal silicon; a Focal Plane Assembly (FPA) made of back-illuminated CCD's capable of detecting X-rays with excellent quantum efficiency; and a composite Telescope Tube that structurally links the MA and FPA. The MA consists of 5,972 silicon mirror segments mounted into five subassemblies called meta-shells. A meta-shell is constructed from an annular central structural shell covered with interlocking layers of mirror segments. This paper describes the requirements, design, and analysis of the XTA subsystems with particular focus on the MA

A new perspective on robot ethics through investigating human–robot interactions with older adults

This work explored the use of human–robot interaction research to investigate robot ethics. A longitudinal human–robot interaction study was conducted with self-reported healthy older adults to determine whether expression of artificial emotions by a social robot could result in emotional deception and emotional attachment. The findings from this study have highlighted that currently there appears to be no adequate tools, or the means, to determine the ethical impact and concerns ensuing from long-term interactions between social robots and older adults. This raises the question whether we should continue the fundamental development of social robots if we cannot determine their potential negative impact and whether we should shift our focus to the development of human–robot interaction assessment tools that provide more objective measures of ethical impact