Case series on obstetrical outcomes in patient with uterine malformations

Congenital uterine anomalies occur due to abnormal fusion of mullerian duct during embryonic life. It is associated with high incidences of reproductive failures and adverse obstetrical outcomes. It may be associated with malpresentation, preterm labour, or recurrent pregnancy losses. Authors report a case series of 7 patients which were admitted in obstetrics and gynaecology department of SP medical college and associated group of hospitals between time period of March 2019 to July 2019. Among 7 cases 6 cases were associated with malpresentation, 1 with abortion, and 1 with preterm labour. This series shows that uterine anomalies are associated with different obstetrical outcomes varying from totally uneventful antenatal and postnatal period to abortion or preterm labour. Prenatal diagnosis of uterine anomaly may help in improving the obstetrical outcome in these patients.

A cross sectional study to evaluate serum calcium levels among pregnant women and it's association with preeclampsia and delivery outcomes at tertiary care Hospital Bikaner, Rajasthan

Background: Hypertensive disorders of pregnancy, including preeclampsia complicates about 10% of pregnancies worldwide. Preeclampsia is one of the major cause of maternal and perinatal morbidity and mortality worldwide. According to the National Health Portal of India, the incidence of preeclampsia is reported to be about 8-10% among pregnant women. The present study was aimed to compare mean serum calcium levels in preeclamptic and normotensive pregnant women at third trimester of gestation and assess relationship between maternal serum calcium levels, severity of disease and overall maternal and perinatal outcome.Methods: This was a cross sectional study conducted on 200 females divided into two groups (i.e. Study and Control Group) from 1st November 2019 to 31st October 2020. Informed consent was obtained for subjecting. Detailed history and clinical examination were performed. Serum calcium level was measured in both groups by spectrophotometric method.Results: Mean serum calcium level in study group (preeclamptic) was 7.84±0.74 mg/dl while in control group (normotensive) mean serum calcium level was 9.68±0.97 mg/dl. Serum calcium level was significantly lower in preeclamptic women than normotensive pregnant women (p<0.001).Serum calcium showed significant negative correlation with systolic and diastolic blood pressure.Conclusions: This study concludes that hypocalcaemia may have a role in aetiology of preeclampsia and adverse maternal and perinatal outcome. Thus intake of calcium supplements may help in reduction of incidence of preeclampsia especially in a population of a developing country

Assessment of the survival of dental implants in irradiated jaws following treatment of oral cancer: A retrospective study

Background: In patients undergoing head and neck surgery for various pathologic conditions, implants are one of the best restorative options and are increasing widely used. Therefore, we evaluated the success of dental implants in the irradiated jaws of patients following treatment of oral cancer oral cancer treated patients. Materials and Methods: Data of oral cancer treated patients was collected retrospectively from 2002 to 2008. We took 46 oral cancer treated patients in which implants were placed in irradiated jaws for rehabilitation.Results: It was found that out of 162 dental implants placed, 52 failed. Furthermore, there was no variation in the implant survival rate in between both the jaws.  Radiation dose of &lt;50 Gy units also showed significantly increased amount of implant survival rate.Conclusions: Implant survival is multifactorial and depends upon a number of factors like level of radiation exposure in that area, time gap between last radiation doses etc., Further research is required in this field to improve the esthetics and quality of life of cancer treated patients.Keywords: Cancer, dental implants, radiation therap

Original Article - Efficacy of low dose intravenous immunoglobulins in children with toxic epidermal necrolysis: An open uncontrolled study

Background: High dose intravenous immunoglobulins (IVIG) have emerged as a promising new therapy for treating the rare but potentially fatal drug reaction toxic epidermal necrolysis (TEN). Experimental in vitro studies support the view that IVIG can block the fas-fas ligand mediated apoptosis in TEN. Methods: Ten pediatric patients of TEN were treated with IVIG (0.05 - 0.1 gm/kg/day) along with antibiotics and supportive care. Results: Patients with 67% of mean body surface area of involvement showed an average of 2.1 days for arrest of progression of lesions and 8.1 days for complete reepithelization. There was no mortality. Conclusions: Low dose IVIG appears to be a safe and effective treatment for TEN in children. Randomized trials are needed to further evaluate the efficacy of IVIG and compare it with other therapeutic modalities

Attitude and perception of dental students towards computer-mediated learning during COVID-19 pandemic in Central India

Context: Due to emergence of COVID-19 pandemic, educational institutions were ordered to be closed to protect students from viral exposure. The mode of teaching had to be shifted from face-to-face to digital learning to complete the prescribed syllabi in a stipulated time period. Aim: This study aimed to assess the attitude and perception of undergraduate dental students towards computer-mediated teaching during COVID-19 pandemic. Settings and Design: After obtaining informed consent, a questionnaire study was conducted online using Google Forms among undergraduate students of dental colleges in Central India. Methods and Material: A standard pre-tested questionnaire in English was used, which consisted of 3 parts. The first part recorded demographic data, second part evaluated learning and third part assessed the attitude of the students to computer-mediated learning. Statistical analysis used: 1045 students participated in the study. Learning and Attitude Score was calculated and mean score was compared between groups using ANOVA. Results: Most of the students (above 80%) believed the modern education is inconceivable without computer technology. However, only about 30% believed that such teaching can substitute traditional way of learning. Those with advanced skills in computers reported to have better experience with computer-mediated learning (p&lt;0.05).&nbsp

Selective and rapid determination of raltegravir in human plasma by liquid chromatographyâtandem mass spectrometry in the negative ionization mode

A selective and rapid high-performance liquid chromatographyâtandem mass spectrometry method was developed and validated for the quantification of raltegravir using raltegravir-d3 as an internal standard (IS). The analyte and IS were extracted with methylene chloride and n-hexane solvent mixture from 100 µL human plasma. The chromatographic separation was achieved on a Chromolith RP-18e endcapped C18 (100 mmÃ4.6 mm) column in a run time of 2.0 min. Quantitation was performed in the negative ionization mode using the transitions of m/z 443.1â316.1 for raltegravir and m/z 446.1â319.0 for IS. The linearity of the method was established in the concentration range of 2.0â6000 ng/mL. The mean extraction recovery for raltegravir and IS was 92.6% and 91.8%, respectively, and the IS-normalized matrix factors for raltegravir ranged from 0.992 to 0.999. The application of this method was demonstrated by a bioequivalence study on 18 healthy subjects. Keywords: Raltegravir, LCâESIâMS/MS, Negative ionization mode, Human plasma, Bioequivalence stud

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Not AvailableStudy on water absorption characteristics of paddy variety (MTU-1010) suitable for flaking was carried out at different water temperatures (30, 40, 50, 60 and 70°C). By soaking paddy at different temperatures mentioned above, it was found that soaking in water at 60°C for 4 hours (final mc of paddy being 26.48 % wb) is equivalent to traditional soaking at room temperature for 24 h (final mc being 26.32 % wb). Similarly, it was observed for BB- 11 that soaking in water at 60°C for 3.5 hours (final mc of paddy being 25.28 % wb) is equivalent to traditional soaking at room temperature for 24 h (final mc being 25.42 % wb). Hence, the quantity of water required for soaking to desired moisture content was found out taking into account initial and final moisture content, bed porosity, the water required to keep the paddy submerged and evaporation of water. It was estimated that 250g MTU-1010 requires 400 ml water and 250g BB-11 requires 300 ml water. Further, water absorption characteristics of paddy (variety: MTU-1010) was also conducted under ambient conditions up to 36 hours at intervals of 6h. The mc of paddy increased from initial 8.33% to final 35.26 % wb for MTU-1010 variety while it varied from 7.33% to 32.33% wb in case of BB-11 variety. It was observed in both the cases that the uptake of moisture initially was fast which gradually decreased with the passage of time. The saturation moisture content (SMC) of paddy was found after 50 hours of ambient water soaking to be 37.10% (wb) for MTU-1010 variety and 35.33% wb in case of BB-11 variety.Not Availabl