9 research outputs found
Transport Properties of the Quark-Gluon Plasma -- A Lattice QCD Perspective
Transport properties of a thermal medium determine how its conserved charge
densities (for instance the electric charge, energy or momentum) evolve as a
function of time and eventually relax back to their equilibrium values. Here
the transport properties of the quark-gluon plasma are reviewed from a
theoretical perspective. The latter play a key role in the description of
heavy-ion collisions, and are an important ingredient in constraining particle
production processes in the early universe. We place particular emphasis on
lattice QCD calculations of conserved current correlators. These Euclidean
correlators are related by an integral transform to spectral functions, whose
small-frequency form determines the transport properties via Kubo formulae. The
universal hydrodynamic predictions for the small-frequency pole structure of
spectral functions are summarized. The viability of a quasiparticle description
implies the presence of additional characteristic features in the spectral
functions. These features are in stark contrast with the functional form that
is found in strongly coupled plasmas via the gauge/gravity duality. A central
goal is therefore to determine which of these dynamical regimes the quark-gluon
plasma is qualitatively closer to as a function of temperature. We review the
analysis of lattice correlators in relation to transport properties, and
tentatively estimate what computational effort is required to make decisive
progress in this field.Comment: 54 pages, 37 figures, review written for EPJA and APPN; one parag.
added end of section 3.4, and one at the end of section 3.2.2; some Refs.
added, and some other minor change
Assessment of plasma chitotriosidase activity, CCL18/PARC concentration and NP-C suspicion index in the diagnosis of Niemann-Pick disease type C: A prospective observational study
Background: Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C. Methods: In a prospective observational cohort study, incorporating a retrospective determination of NP-C SI scores, two different diagnostic approaches were applied in two separate groups of unrelated patients from 51 Spanish medical centers (n = 118 in both groups). From Jan 2010 to Apr 2012 (Period 1), patients with =2 clinical signs/symptoms of NP-C were considered ''suspected NP-C'' cases, and NPC1/NPC2 sequencing, plasma chitotriosidase (ChT), CCL18/PARC and sphingomyelinase levels were assessed. Based on findings in Period 1, plasma ChT and CCL18/PARC, and NP-C SI prediction scores were determined in a second group of patients between May 2012 and Apr 2014 (Period 2), and NPC1 and NPC2 were sequenced only in those with elevated ChT and/or elevated CCL18/PARC and/or NP-C SI =70. Filipin staining and 7-ketocholesterol (7-KC) measurements were performed in all patients with NP-C gene mutations, where possible. Results: In total across Periods 1 and 2, 10/236 (4%) patients had a confirmed diagnosis o NP-C based on gene sequencing (5/118 4.2%] in each Period): all of these patients had two causal NPC1 mutations. Single mutant NPC1 alleles were detected in 8/236 (3%) patients, overall. Positive filipin staining results comprised three classical and five variant biochemical phenotypes. No NPC2 mutations were detected. All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or NP-C SI scores =70. Plasma 7-KC was higher than control cut-off values in all patients with two NPC1 mutations, and in the majority of patients with single mutations. Family studies identified three further NP-C patients. Conclusion: This approach may be very useful for laboratories that do not have mass spectrometry facilities and therefore, they cannot use other NP-C biomarkers for diagnosis