13 research outputs found
HM 8: The Fraternity of the Blue Uniform
Admiral Richard G. Colbert\u27s particular approach to U.S. naval strategy, placing as it did great emphasis on the need to enhance cooperation between the U.S. Navy and friendly maritime forces, was not entirely different from the maritime strategy of the 1980s.https://digital-commons.usnwc.edu/usnwc-historical-monographs/1007/thumbnail.jp
Program transformations using temporal logic side conditions
This paper describes an approach to program optimisation based on transformations, where temporal logic is used to specify side conditions, and strategies are created which expand the repertoire of transformations and provide a suitable level of abstraction. We demonstrate the power of this approach by developing a set of optimisations using our transformation language and showing how the transformations can be converted into a form which makes it easier to apply them, while maintaining trust in the resulting optimising steps. The approach is illustrated through a transformational case study where we apply several optimisations to a small program
Designing Bioactive Delivery Systems for Tissue Regeneration
The direct infusion of macromolecules into defect sites generally does not impart adequate physiological responses. Without the protection of delivery systems, inductive molecules may likely redistribute away from their desired locale and are vulnerable to degradation. In order to achieve efficacy, large doses supplied at interval time periods are necessary, often at great expense and ensuing detrimental side effects. The selection of a delivery system plays an important role in the rate of re-growth and functionality of regenerating tissue: not only do the release kinetics of inductive molecules and their consequent bioactivities need to be considered, but also how the delivery system interacts and integrates with its surrounding host environment. In the current review, we describe the means of release of macromolecules from hydrogels, polymeric microspheres, and porous scaffolds along with the selection and utilization of bioactive delivery systems in a variety of tissue-engineering strategies