Innovatory production of radioisotopes 117mSn, 186Re and 188Re for laboratory tests and the future application in nuclear medicine

In this work, innovatory production of three radioisotopes 117mSn, 186Re and 188Re, which can be used in nuclear medicine, is described. The natural tin and rhenium targets were irradiated by a high-energy 20 MV X-ray therapeutic beam from a medical linear accelerator. Additionally, the targets were in the photoneutron field. The radioisotopes were obtained in photonuclear and neutron reactions. A special lead-PMMA system was used to increase the slowed-down neutron flux in the target volume. The specific activities of 117mSn, 186Re and 188Re are 11 kBq/g, 2.6 MBq/g and 0.26 MBq/g in the saturation state, respectively. The produced amounts of the radioisotopes of tin and rhenium are sufficient for various laboratory tests in nuclear medicine

Human ADSC xenograft through IL-6 secretion activates M2 macrophages responsible for the repair of damaged muscle tissue

Background: Adipose-derived mesenchymal stromal cells (ADSCs) are multipotent stromal cells. The cells secrete a number of cytokines and growth factors and show immunoregulatory and proangiogenic properties. Their properties may be used to repair damaged tissues. The aim of our work is to explain the muscle damage repair mechanism with the utilization of the human adipose-derived mesenchymal stromal cells (hADSCs). Methods: For the hADSCs isolation, we used the subcutaneous adipose tissue collected during the surgery. The murine hind limb ischemia was used as a model. The unilateral femoral artery ligation was performed on 10–12-week-old male C57BL/6NCrl and NOD SCID mice. The mice received PBS− (controls) or 1 × 106 hADSCs. One, 3, 7, 14 and 21days after the surgery, we collected the gastrocnemius muscles for the immunohistochemical analysis. The results were analyzed with relevant tests using the Statistica software. Results: The retention time of hADSCs in the limb lasted about 14 days. In the mice receiving hADSCs, the improvement in the functionality of the damaged limb occurred faster than in the control mice. More new blood vessels were formed in the limbs of the mice receiving hADSCs than in limbs of the control mice. hADSCs also increased the infiltration of the macrophages with the M2 phenotype (7-AAD−/CD45+/F4/80+/CD206+) into the ischemic limbs. hADSCs introduced into the limb of mice secreted interleukin-6. This cytokine stimulates the emergence of the proangiogenic M2 macrophages, involved, among others, in the repair of a damaged tissue. Both macrophage depletion and IL-6 blockage suppressed the therapeutic effect of hADSCs. In the mice treated with hADSCs and liposomes with clodronate (macrophages depletion), the number of capillaries formed was lower than in the mice treated with hADSCs alone. Administration of hADSCs to the mice that received siltuximab (human IL-6 blocker) did not cause an influx of the M2 macrophages, and the number of capillaries formed was at the level of the control group, as in contrast to the mice that received only the hADSCs. Conclusions: The proposed mechanism for the repair of the damaged muscle using hADSCs is based on the activity of IL-6. In our opinion, the cytokine, secreted by the hADSCs, stimulates the M2 macrophages responsible for repairing damaged muscle and forming new blood vessels

Survey on opportunities and barriers in lighting controls

This report summarizes a survey performed in eight countries on the status quo of daylight and electric lighting control systems. Feedback from more than 100 international experts (building / facility managers and planers) was evaluated. The aim of the survey was to identify the perception of the different possibilities of the current lighting control solutions and the expectations about the control systems. The survey aims to provide a mapping of the current lighting control systems available at the market and an overview of which functions are perceived as most important and which areas are found to be improved. Participants of the survey had to rank each question in relation to the perceived importance and the need for improvement. The survey enclosed five general topics; energy, operational aspects, occupant control, occupant comfort and control functionality.The findings from the summary suggest, that the two main reasons for the implementation of lighting control systems are:1. The possibility to reduce the electric lighting consumptions and2. The opportunity to increase the user’s well-being and thereby reduce complaints from the users.From a user perspective, this means that the lighting system must ensure visual acuity and comfort by providing a sufficient level of illuminance and the ability to regulate the light level. Always in relation to the task and the ambient light in the space, and thereby creating a pleasant and comfortable light environment. Research suggests, when giving the users some manual control possibilities, the satisfaction with the lighting conditions in general increases The users should be able to both increase and dim the light levels or completely turn it off. Thissuggests, if the lighting control system is designed to regulate the illuminance automatically, it should be provided some kind of manual override. This is supported by the findings in the surveys, where all countries in one way oranother find it important to provide the users with some possibility of user control. This as well applies to the control of the shading system in relation to avoid glare from high daylight intensities and undesired solar radiationcoming into the space. This increases the risk of overheating, resulting in an increased ventilation and/or cooling need leading to a higher energy use. However, in the two Scandinavian countries, it is found less important withthe possibility to control the shadings in order to reduce glare from daylight and undesired heat transmission in the space. This may be due to the higher latitude and thereby a lower intensity of the daylight.In relation to the importance of user control, the findings additionally suggest, that the occupant control must be simple to operate. A control system which is easy for the users to understand intuitive, will most likely increase the chances of an ‘optimal’ interaction with the system. If the system does not meet the users need or is too complex to use, the possibility that the users will try to override the control systems increases, and this will most likely result in increased energy consumption

HISTORY OF LAMPS AND LUMINAIRES FOR DOMESTIC ENVIRONMENT. PART ONE

This paper reflects on the history of decorative luminaire design. The development of the new sources of light within residential environment has been changing the luminaire design. Residential dwellings have been lit by a lot of light sources through the centuries form a point lamps like candle or incandescent lamps to linear florescent lamps and LED strips. A development of SSL technology introduced an idea of lit surfaces. Energy efficiency of light sources and luminaires has been playing more important role since an idea of sustainable design had entered the residential dwellings. The design of electric lighting is combined with daylight design and applied into modern home setups. The changes in energy efficient lighting technology have increased the complexity of luminaire design often leaving a user with a wide choice of luminaires but with a lack of knowledge how to use them

Administrative procedure for a building permit

Celem niniejszej pracy jest przybliżenie procesu uzyskania pozwolenia na budowę w oparciu o przepisy prawne, w tym przepisy związane z jego uzyskaniem. Celem jest również poszerzenie spojrzenia na proces budowlany nie tylko jako uzyskanie pozwolenia na budowę, ale także na realizację inwestycji, jej zakończenie, następnie oddanie do użytku obiektu budowlanego i jego utrzymanie.The aim of this work is to present the process of obtaining a building permit based on legal provisions, including provisions related to obtaining it. The aim is also to broaden the view on the construction process not only as obtaining a building permit, but also on the implementation of the investment, its completion, then commissioning of the building and its maintenance

Discussing daylight simulations in a proposal for online daylighting education

There is increasing interest concerning daylighting in the building sector. However, such knowledge is difficult to penetrate the curricula of architects and designers as existing educational programmes often do not provide sufficient training on BPS. This also leads to superficial use of daylight simulations.This paper presents a proposal for a needs-based education package on daylighting design, that mixes modular eLearning and an intensive summer school, called NLITED.The NLITED model includes modules on daylight simulation whose implementation (in eLearning key) can trigger a constructive discussion and receive valuable feedback from the Nordic community of BPS specialists

NLITED - New Level of Integrated Techniques for Daylighting Education: preliminary data on the use of an e-learning platform

Project NLITED – New Level of Integrated Techniques for Daylighting Education - is an educational project for students and professionals. The project's objective is to create and develop an online eLearning platform with 32 eModules dedicated to daylight knowledge. The project also offers e-learners two summer school training where the theoryis put into practice. The platform was launched on January 31, 2022. The paper analyses the participation during the first four months of online activity until May 31, 2022. It discusses which eModules have received the highest participation rate and which have the lowest. These data are compared to the preferences on modules expressed by different panels of experts. The experts expressed their recommendations for specific educational content during workshops conducted in 2021, which led to the definition of the curriculum. Furthermore, participants also fill out an evaluation test on the quality and the usability of the eModule(s) they have taken. This information leads to the amendments of the ePlatform which are in the scope of action for the final year of the NLTED project