A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function

Machine learning‐based LoRa localisation using multiple received signal features

Abstract Low‐power localisation systems are crucial for machine‐to‐machine communication technologies. This article investigates LoRa technology for localisation using multiple features of the received signal, such as Received Signal Strength Indicator (RSSI), Spreading Factors (SF), and Signal to Noise Ratio (SNR). A novel range‐based technique to estimate the distance of a target node from a LoRa gateway using machine‐learning models that incorporates SF, SNR, and RSSI to train the models is proposed. A modified trilateration approach is then used to localise the target node from three gateways. Our experiment used three LoRaWAN gateways and two sensor nodes, on a sports oval with an approximate area coverage of 30,000 square metres. The authors also used a public LoRaWAN dataset to build a model test the proposed method and compare both range‐based distance mapping with trilateration and fingerprint‐based direct location estimation techniques. Our method achieved an average distance error of 43.97 m on our experimental dataset. The results show that the combination of RSSI, SNR, and SF‐based distance mapping provides ∼10% improvement on ranging accuracy and 26.58% higher accuracy for trilateration‐based localisation when compared with just using RSSI. Our method also achieved 50% superior localisation accuracy with fingerprint‐based direct location estimation approaches

Renewable Energy-Based Energy-Efficient Off-Grid Base Stations for Heterogeneous Network

The heterogeneous network (HetNet) is a specified cellular platform to tackle the rapidly growing anticipated data traffic. From a communications perspective, data loads can be mapped to energy loads that are generally placed on the operator networks. Meanwhile, renewable energy-aided networks offer to curtailed fossil fuel consumption, so to reduce the environmental pollution. This paper proposes a renewable energy based power supply architecture for the off-grid HetNet using a novel energy sharing model. Solar photovoltaics (PV) along with sufficient energy storage devices are used for each macro, micro, pico, or femto base station (BS). Additionally, a biomass generator (BG) is used for macro and micro BSs. The collocated macro and micro BSs are connected through end-to-end resistive lines. A novel-weighted proportional-fair resource-scheduling algorithm with sleep mechanisms is proposed for non-real time (NRT) applications by trading-off the power consumption and communication delays. Furthermore, the proposed algorithm with an extended discontinuous reception (eDRX) and power saving mode (PSM) for narrowband internet of things (IoT) applications extends the battery lifetime for IoT devices. HOMER optimization software is used to perform optimal system architecture, economic, and carbon footprint analyses while the Monte-Carlo simulation tool is used for evaluating the throughput and energy efficiency performances. The proposed algorithms are validated through the practical data of the rural areas of Bangladesh from which it is evident that the proposed power supply architecture is energy-efficient, cost-effective, reliable, and eco-friendly

Renewable Energy-Based Energy-Efficient Off-Grid Base Stations for Heterogeneous Network

The heterogeneous network (HetNet) is a specified cellular platform to tackle the rapidly growing anticipated data traffic. From a communications perspective, data loads can be mapped to energy loads that are generally placed on the operator networks. Meanwhile, renewable energy-aided networks offer to curtailed fossil fuel consumption, so to reduce the environmental pollution. This paper proposes a renewable energy based power supply architecture for the off-grid HetNet using a novel energy sharing model. Solar photovoltaics (PV) along with sufficient energy storage devices are used for each macro, micro, pico, or femto base station (BS). Additionally, a biomass generator (BG) is used for macro and micro BSs. The collocated macro and micro BSs are connected through end-to-end resistive lines. A novel-weighted proportional-fair resource-scheduling algorithm with sleep mechanisms is proposed for non-real time (NRT) applications by trading-off the power consumption and communication delays. Furthermore, the proposed algorithm with an extended discontinuous reception (eDRX) and power saving mode (PSM) for narrowband internet of things (IoT) applications extends the battery lifetime for IoT devices. HOMER optimization software is used to perform optimal system architecture, economic, and carbon footprint analyses while the Monte-Carlo simulation tool is used for evaluating the throughput and energy efficiency performances. The proposed algorithms are validated through the practical data of the rural areas of Bangladesh from which it is evident that the proposed power supply architecture is energy-efficient, cost-effective, reliable, and eco-friendly

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

Metabolic diseases are a worldwide problem but the underlying genetic factors and their relevance to metabolic disease remain incompletely understood. Genome-wide research is needed to characterize so-far unannotated mammalian metabolic genes. Here, we generate and analyze metabolic phenotypic data of 2016 knockout mouse strains under the aegis of the International Mouse Phenotyping Consortium (IMPC) and find 974 gene knockouts with strong metabolic phenotypes. 429 of those had no previous link to metabolism and 51 genes remain functionally completely unannotated. We compared human orthologues of these uncharacterized genes in five GWAS consortia and indeed 23 candidate genes are associated with metabolic disease. We further identify common regulatory elements in promoters of candidate genes. As each regulatory element is composed of several transcription factor binding sites, our data reveal an extensive metabolic phenotype-associated network of co-regulated genes. Our systematic mouse phenotype analysis thus paves the way for full functional annotation of the genome