Pattern Dynamics of Vortex Ripples in Sand: Nonlinear Modeling and Experimental Validation

Vortex ripples in sand are studied experimentally in a one-dimensional setup with periodic boundary conditions. The nonlinear evolution, far from the onset of instability, is analyzed in the framework of a simple model developed for homogeneous patterns. The interaction function describing the mass transport between neighboring ripples is extracted from experimental runs using a recently proposed method for data analysis, and the predictions of the model are compared to the experiment. An analytic explanation of the wavelength selection mechanism in the model is provided, and the width of the stable band of ripples is measured.Comment: 4 page

Phage Display Selection, Identification, and Characterization of Novel Pancreatic Cancer Targeting Peptides

Pancreatic cancer is characterized by a 5-year survival rate of 3%, in part due to inadequate detection methods. The small size of peptides offers advantages regarding molecular targeting. Thus, peptides may be used in detection of pancreatic cancer. Here, peptides that target pancreatic cancer cells were selected using phage display technology using a 15-mer fUSE5 library. Phage were pre-cleared against immortalized pancreatic cells (hTERT-HPNE), followed by selections against pancreatic cancer (Mia Paca-2) cells. Next-generation sequencing identified two peptides, MCA1 and MCA2, with a Log2 fold change (Mia Paca-2/ hTERT-HPNE) >1.5. Modified ELISA and fluorescent microscopy showed that both peptides bound significantly higher to Mia Paca-2 cells, and not to hTERT-HPNE, embryonic kidney (HEK 293), ovarian (SKOV-3) and prostate cancer (LNCaP) cell lines. Further characterization of MCA1 and MCA2 revealed EC50 values of 16.11 µM (95% CI [9.69, 26.31 µM]) and 97.01 µM (95% CI [58.64, 166.30 µM]), respectively. Based on these results, MCA1 was selected for further studies. A competitive dose response assay demonstrated specific binding and an IC50 value of 2.15 µM (95% CI [1.28, 3.62 µM]). Taken together, this study suggests that MCA1 may be used as a pancreatic cancer targeting ligand for detection of the disease

Cost effective large blade components by using carbon fibres

For large off-shore wind turbines, blades with relative low blade mass are becoming more important. The economic use of large-tow carbon fibers can help achieve lower blade masses. Basic material design data have been established for two promising material combinations, including the fatigue properties for Panex33/epoxy. Blade root joints have been developed in a carbon/glass combination, resulting in a better price performance ratio. The initial cost assessment on a blade dominated by severe fatigue loads shows that application of carbon fibers in the spar leads to cost reductions

Cost Effective Large Blade Components by Using Carbon Fibers

For large off-shore wind turbines, blades with relative low blade mass are becoming more important. The economic use of large-tow carbon fibers can help achieve lower blade masses. Basic material design data have been established for two promising material combinations, including the fatigue properties for Panex33/epoxy. Blade root joints have been developed in a carbon/glass combination, resulting in a better price performance ratio. The initial cost assessment on a blade dominated by severe fatigue loads shows that application of carbon fibers in the spar leads to cost reductions

Universities as Catalysts for Community Building among Informal STEM educators: The Story of POISED

POISED: Partners for Outreach in Informal STEM Education; STEM: Science, Technology, Engineering, Mathematic